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Q9UX10 (PYRF_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:SSO0616
ORF Names:C08_034
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134618

Regions

Region59 – 6810Substrate binding By similarity
Region164 – 17411Substrate binding By similarity

Sites

Active site611Proton donor By similarity
Binding site111Substrate By similarity
Binding site301Substrate By similarity
Binding site1151Substrate By similarity
Binding site1871Substrate; via amide nitrogen By similarity
Binding site1881Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9UX10 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 48F3E83DB0F043FF

FASTA22224,701
        10         20         30         40         50         60 
MLKSRVILAM DKPLSYQVLK EMENELYGIK VGLPLVLDLG VDKTRELLIG LDVEEIIVDF 

        70         80         90        100        110        120 
KLADIGYIMK SIVERLSFAN SFIAHSFIGV KGSLDELKRY LDANSKNLYL VAVMSHEGWS 

       130        140        150        160        170        180 
TLFADYIKNV IREISPKGIV VGGTKLDHIT QYRRDFEKMT IVSPGMGSQG GSYGDAVCAG 

       190        200        210        220 
ADYEIIGRSI YNAGNPLTAL RTINKIIEDK VMKCKGAIFR KK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y18930 Genomic DNA. Translation: CAB57684.1.
AE006641 Genomic DNA. Translation: AAK40927.1.
PIRH90208.
RefSeqNP_342137.1. NC_002754.1.

3D structure databases

ProteinModelPortalQ9UX10.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0616.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK40927; AAK40927; SSO0616.
GeneID1454894.
KEGGsso:SSO0616.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226069.
KOK01591.
OMATEMSHPG.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-589-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_A. OMPdecase_type1_A.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRF_SULSO
AccessionPrimary (citable) accession number: Q9UX10
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways