Q9UX07 (PYRI_SULSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase regulatory chain

Gene names

Name:	pyrI
Ordered Locus Names:	SSO0613

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in allosteric regulation of aspartate carbamoyltransferase By similarity. HAMAP MF_00002
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00002
Subunit structure	Contains catalytic and regulatory chains.
Sequence similarities	Belongs to the pyrI family.
Sequence caution	The sequence AAK40924.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB57687.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	aspartate carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 159	159	Aspartate carbamoyltransferase regulatory chain HAMAP MF_00002		PRO_0000142343
Sites
	Metal binding	113	1	Zinc By similarity
	Metal binding	118	1	Zinc By similarity
	Metal binding	142	1	Zinc By similarity
	Metal binding	145	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UX07 [UniParc]. Last modified August 2, 2002. Version 2. Checksum: CE20EDD33442EDC3	FASTA	159	17,982
	10 20 30 40 50 60 MISSSKRDEL IVSKIRNGTV IDHIPAGRAL AVLRILGIRG SEGYRVALVM NVESKKIGRK 70 80 90 100 110 120 DIVKIEDRVI DEKEASLITL IAPSATINII RDYVVTEKRH LEVPKQIRGL IKCPNPQCIT 130 140 150 NNDVEAESRF ITISIKPLKL KCKYCEMYIT EDDVIRQIL

References

[1]	"Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2." Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C., Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T., Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E., Medina N. , Peng X., Penny S.L., She Q., St Jean A., van der Oost J., Young F., Zivanovic Y., Doolittle W.F., Ragan M.A., Sensen C.W. Genome 43:116-136(2000) [PubMed: 10701121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]	"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y18930 Genomic DNA. Translation: CAB57687.1. Different initiation. AE006641 Genomic DNA. Translation: AAK40924.1. Different initiation.
PIR	E90208.
RefSeq	NP_342134.1. NC_002754.1.
3D structure databases
ProteinModelPortal	Q9UX07.
SMR	Q9UX07. Positions 11-159.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1454891.
GenomeReviews	Gene locus SSO0613 in contig AE006641_GR.
KEGG	sso:SSO0613.
NMPDR	fig|273057.1.peg.557.
Phylogenomic databases
HOGENOM	HBG305327.
OMA	TVIDHIT.
ProtClustDB	PRK00893.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO0613-MONOMER.
Family and domain databases
HAMAP	MF_00002. Asp_carb_tr_reg. [Tree]
InterPro	IPR020545. Asp_carbamoyltransf_reg_N. IPR002801. Asp_carbamoylTrfase_reg. IPR020542. Asp_carbamoyltrfase_reg_C. [Graphical view]
Gene3D	G3DSA:2.30.30.20. PyrI. 1 hit. G3DSA:3.30.70.140. PyrI. 1 hit.
KO	K00610.
Pfam	PF01948. PyrI. 1 hit. PF02748. PyrI_C. 1 hit. [Graphical view]
ProDom	PD006194. Asp_carbamoylTrfase_reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54893. Asp_carbamoylTrfase_reg. 1 hit. SSF57825. Asp_transf_reg_C. 1 hit.
TIGRFAMs	TIGR00240. ATCase_reg. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PYRI_SULSO

Accession

Primary (citable) accession number: Q9UX07

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	August 2, 2002
Last modified:	December 14, 2011
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program