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Q9UWY6

- DGGGP_SULSO

UniProt

Q9UWY6 - DGGGP_SULSO

Protein

Digeranylgeranylglyceryl phosphate synthase

Gene

ubiA-2

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. Can not use other prenyl donors, i.e. farnesyl diphosphate (FPP) and phytyl diphosphate. Moreover, 4-hydroxybenzoate, 1,4-dihydroxy 2-naphthoate, homogentisate, and alpha-glycerophosphate do not function as prenyl acceptor substrates.1 Publication

    Catalytic activityi

    Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.1 Publication

    Cofactori

    Magnesium. Can also use Ca2+, but less efficiently.1 Publication

    Enzyme regulationi

    Inhibited by EDTA in vitro.1 Publication

    pH dependencei

    Optimum pH is 6.0.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranylglycerol-phosphate geranylgeranyltransferase activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. prenyltransferase activity Source: InterPro

    GO - Biological processi

    1. glycerophospholipid metabolic process Source: UniProtKB-UniPathway
    2. phospholipid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-558-MONOMER.
    UniPathwayiUPA00940.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Digeranylgeranylglyceryl phosphate synthase (EC:2.5.1.42)
    Short name:
    DGGGP synthase
    Short name:
    DGGGPS
    Alternative name(s):
    (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase
    Geranylgeranylglycerol-phosphate geranylgeranyltransferase
    Gene namesi
    Name:ubiA-2
    Ordered Locus Names:SSO0583
    ORF Names:C21_016
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282Digeranylgeranylglyceryl phosphate synthasePRO_0000350691Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273057.SSO0583.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UWY6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0382.
    HOGENOMiHOG000152645.
    KOiK17105.
    OMAiSAGIRTY.

    Family and domain databases

    HAMAPiMF_01286. DGGGP_synth.
    InterProiIPR023547. DGGGP_synth.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view]
    PfamiPF01040. UbiA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UWY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLKSYMQLV RIHNVIGAAL GAIMGFLVSS QWYLELKGIL LSALVVGLIA    50
    AGGYVINDVY DVEIDKINKP YRPIPSGKIS VNKAKALSIA LFIIGIALSI 100
    LLNIYALVIA LVTAIGLIYY AKDLKKTGFY GNLLVATTTA LSIFYGGLAF 150
    FSDNWLLRII IPTLYAFFLT LIREIVKGIE DYNGDSLNNV KTLATTLGIN 200
    KSWRIAKILL VLLLIISPLP FFIGFNLIYL ILLILVFIPF TILSIIQKET 250
    IEGASKARTY LKISAISGII AFLLGSLPFF KG 282
    Length:282
    Mass (Da):30,915
    Last modified:May 1, 2000 - v1
    Checksum:i0E98AFDD6590B052
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18930 Genomic DNA. Translation: CAB57717.1.
    AE006641 Genomic DNA. Translation: AAK40896.1.
    PIRiA99205.
    RefSeqiNP_342106.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK40896; AAK40896; SSO0583.
    GeneIDi1454863.
    KEGGisso:SSO0583.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18930 Genomic DNA. Translation: CAB57717.1 .
    AE006641 Genomic DNA. Translation: AAK40896.1 .
    PIRi A99205.
    RefSeqi NP_342106.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali Q9UWY6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO0583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK40896 ; AAK40896 ; SSO0583 .
    GeneIDi 1454863.
    KEGGi sso:SSO0583.

    Phylogenomic databases

    eggNOGi COG0382.
    HOGENOMi HOG000152645.
    KOi K17105.
    OMAi SAGIRTY.

    Enzyme and pathway databases

    UniPathwayi UPA00940 .
    BioCyci SSOL273057:GCH2-558-MONOMER.

    Family and domain databases

    HAMAPi MF_01286. DGGGP_synth.
    InterProi IPR023547. DGGGP_synth.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view ]
    Pfami PF01040. UbiA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    3. "(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids."
      Hemmi H., Shibuya K., Takahashi Y., Nakayama T., Nishino T.
      J. Biol. Chem. 279:50197-50203(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBSTRATE SPECIFICITY, COFACTOR, PH DEPENDENCE, ENZYME REGULATION, SUBCELLULAR LOCATION.
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiDGGGP_SULSO
    AccessioniPrimary (citable) accession number: Q9UWY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 23, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3