Q9UWY1 (Q9UWY1_SULSF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetolactate synthase RuleBase RU003591
EC=2.2.1.6 RuleBase RU003591

Gene names

Name:

ilvB EMBL CAB57722.1

Organism

Sulfolobus solfataricus EMBL CAB57722.1

Taxonomic identifier

2287 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 pyruvate = 2-acetolactate + CO2. RuleBase RU003591
Cofactor	Binds 1 magnesium ion per subunit By similarity. RuleBase RU003591 Binds 1 thiamine pyrophosphate per subunit By similarity. RuleBase RU003591
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. RuleBase RU003591 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4. RuleBase RU003591
Sequence similarities	Belongs to the TPP enzyme family. RuleBase RU003702

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis RuleBase RU003591
Ligand	Magnesium RuleBase RU003591 Metal-binding RuleBase RU003591 Thiamine pyrophosphate RuleBase RU003591
Molecular function	Lyase EMBL CAB57722.1 Transferase RuleBase RU003591
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acetolactate synthase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro lyase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: InterPro thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9UWY1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: CE201C1C9B97598C	FASTA	572	63,212
	10 20 30 40 50 60 MPTGARILVD SLKREGVKVV FGIPGLSNMQ IYDAFVEDLA NGELRHVLMR HEQAAAHAAD 70 80 90 100 110 120 GYARASGVPG VCTATSGPGT TNLTTGLITA YWDSSPVIAI TGNVPRSVMG KMAFQEADAM 130 140 150 160 170 180 GVFENVTKYV IGIKRIDEIP QWIKNAFYIA TTGRPGPVVV DIPRDIFYEK MEEIKWPEKP 190 200 210 220 230 240 LVKGYRDFPT RIDRLALKKA AEILINAERP IILVGTGVVW ANATPEVLEL AELLHIPIVS 250 260 270 280 290 300 TFPGKTAIPH DHPLYFGPMG YYGRAEASMA ALESDAMLVV GARFSDRTFT SYDEMVETRK 310 320 330 340 350 360 KFIMVNIDPT DGEKAIKVDV GLYGNAKIIL RELIKAIITL GQKRDKSAWI KRVKEYKEYY 370 380 390 400 410 420 SQFYYTEENG KLKPWKIMKT IRQSLPRDAI VTTGVGQHQM WAEVFWEVLE PRTFLTSSGM 430 440 450 460 470 480 GTMGFGLPAA MGAKLARPDK IVVDLDGDGS FLMTGTNLAT AVDEHIPVIS VIFDNRTLGL 490 500 510 520 530 540 VRQVQDLFFG RRIVGVDYGP SPDFVKLAEA FGALGFNATT YEEIEKSIKS AIKEDIPAVI 550 560 570 RVPVDKEELA LPTLPPGGRL KQVILRDPRK SS

References

[1]

"Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2." Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C., Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T., Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E., Medina N. , Peng X., Penny S.L., She Q., St Jean A., van der Oost J., Young F., Zivanovic Y., Doolittle W.F., Ragan M.A., Sensen C.W. Genome 43:116-136(2000) [PubMed: 10701121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: P2 EMBL CAB57722.1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y18930 Genomic DNA. Translation: CAB57722.1.
PIR	E90204.
RefSeq	NP_342102.1. NC_002754.1.
3D structure databases
HSSP	HSSP built from PDB template 1JSC based on UniProtKB P07342.
ProteinModelPortal	Q9UWY1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1454859.
NMPDR	fig|273057.1.peg.525.
Phylogenomic databases
HOGENOM	HBG323037.
OMA	WQNLYYG.
PhylomeDB	Q9UWY1.
ProtClustDB	PRK06456.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO0579-MONOMER.
Family and domain databases
InterPro	IPR012846. Acetolactate_synth_lsu. IPR012000. Thiamin_PyroP_enz_cen_dom. IPR012001. Thiamin_PyroP_enz_TPP-bd_dom. IPR000399. TPP-bd_CS. IPR011766. TPP_enzyme-bd_C. [Graphical view]
PANTHER	PTHR18968:SF13. PTHR18968:SF13. 1 hit.
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF00205. TPP_enzyme_M. 1 hit. PF02776. TPP_enzyme_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00118. Acolac_lg. 1 hit.
PROSITE	PS00187. TPP_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9UWY1_SULSF

Accession

Primary (citable) accession number: Q9UWY1

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)