V-type ATP synthase alpha chain - Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

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Q9UWW6 (VATA_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 78. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
V-type ATP synthase alpha chain
EC=3.6.3.14

Alternative name(s):
V-ATPase subunit A

Gene names

Name:	atpA
Ordered Locus Names:	SSO0563

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	592 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. HAMAP MF_00309
Catalytic activity	ATP + H₂O + H⁺(In) = ADP + phosphate + H⁺(Out). HAMAP MF_00309
Sequence similarities	Belongs to the ATPase alpha/beta chains family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	proton-transporting two-sector ATPase complex, catalytic domain Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hydrogen ion transporting ATP synthase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro proton-transporting ATPase activity, rotational mechanism Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 592

592

V-type ATP synthase alpha chain HAMAP MF_00309

PRO_0000144606

Regions

Nucleotide binding

233 – 240

ATP Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9UWW6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 04875AD8DC7ADB07
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FASTA

592

66,412

        10         20         30         40         50         60 
MDNGRIVRIN GPLVVADNMR NAQMYEVVEV GEPRLIGEIT RIEGDRAFIQ VYEDTSGIKP 

        70         80         90        100        110        120 
NEPVYRTGAP LSIELGPGLI GKIFDGLQRP LDSIKELTKS PFIARGIKVP SIDRKTKWHF 

       130        140        150        160        170        180 
VPKVKKGDKV EGGSIIGIVN ETPLVEHRIL VPPYVHGTLK EVVAEGDYTV EDPIAIVDMN 

       190        200        210        220        230        240 
GDEVPVKLMQ KWPVRIPRPF KEKLEPTEPL LTGTRVLDTI FPIAKGGTAA IPGPFGSGKT 

       250        260        270        280        290        300 
VTLQSLAKWS AAKIVIYVGC GERGNEMTDE LRQFPSLKDP WTGRPLLERT ILVANTSNMP 

       310        320        330        340        350        360 
VAAREASIYV GITMAEYFRD QGYDTLLVAD STSRWAEALR DLGGRMEEMP AEEGFPSYLP 

       370        380        390        400        410        420 
SRLAEYYERA GRVKTIGNPE RFGSVTVASA VSPPGGDFTE PVTSQTLRFV KVFWPLDVSL 

       430        440        450        460        470        480 
AQARHYPAIN WLQGFSAYVD LVANWWNTNV DPKWREMRDM MVRTLIREDE LRQIVRLVGP 

       490        500        510        520        530        540 
ESLAEKDKLI LETARLIKEA FLKQNAYDDI DAFSSPQKQA RIMRLIYLFN TYASKLVERG 

       550        560        570        580        590 
IPTKKIVDSM GQLLPEIIRS KAAIKNDELN RYDELERKLI TVFENLEKEA GT

« Hide

References

[1]	"Gene content and organization of a 281-kbp contig from the genome of the extremely thermophilic archaeon, Sulfolobus solfataricus P2." Charlebois R.L., Singh R.K., Chan-Weiher C.C.-Y., Allard G., Chow C., Confalonieri F., Curtis B., Duguet M., Erauso G., Faguy D., Gaasterland T., Garrett R.A., Gordon P., Jeffries A.C., Kozera C., Kushwaha N., Lafleur E., Medina N. Sensen C.W. Genome 43:116-136(2000) [PubMed: 10701121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]	"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y18930 Genomic DNA. Translation: CAB57737.1. AE006641 Genomic DNA. Translation: AAK40879.1.
PIR	H90202.
RefSeq	NP_342089.1. NC_002754.1.
3D structure databases
ProteinModelPortal	Q9UWW6.
SMR	Q9UWW6. Positions 59-591.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1454846.
GenomeReviews	Gene locus SSO0563 in contig AE006641_GR.
KEGG	sso:SSO0563.
NMPDR	fig\|273057.1.peg.512.
Phylogenomic databases
HOGENOM	HBG288114.
OMA	SENKITW.
ProtClustDB	PRK04192.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO0563-MONOMER.
Family and domain databases
HAMAP	MF_00309. ATP_synth_A_arch. [Tree]
InterPro	IPR005726. ATPase_A1-cplx_asu. IPR003593. ATPase_AAA+_core. IPR018118. ATPase_F1/A1-cplx_a/bsu_N. IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C. IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. IPR024034. ATPase_F1_bsu/V1_C. IPR022878. V-ATPase_su_A/alpha. [Graphical view]
Gene3D	G3DSA:1.10.1140.10. G3DSA:1.10.1140.10. 1 hit.
KO	K02117.
Pfam	PF00006. ATP-synt_ab. 1 hit. PF00306. ATP-synt_ab_C. 1 hit. PF02874. ATP-synt_ab_N. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF47917. ATPase_a/b_C. 1 hit. SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMs	TIGR01043. ATP_syn_A_arch. 1 hit.
PROSITE	PS00152. ATPASE_ALPHA_BETA. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VATA_SULSO

Accession

Primary (citable) accession number: Q9UWW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	May 1, 2000
Last modified:	November 16, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents