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Protein

TATA-box-binding protein

Gene

tbp

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
Box A-binding protein
Short name:
BAP
TATA sequence-binding protein
Short name:
TBP
TATA-box factor
Gene namesi
Name:tbp
Ordered Locus Names:Saci_1336
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001540241 – 197TATA-box-binding proteinAdd BLAST197

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1336.

Structurei

Secondary structure

1197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 22Combined sources12
Helixi29 – 35Combined sources7
Turni43 – 45Combined sources3
Beta strandi47 – 53Combined sources7
Turni54 – 57Combined sources4
Beta strandi58 – 62Combined sources5
Beta strandi66 – 71Combined sources6
Helixi76 – 92Combined sources17
Beta strandi102 – 113Combined sources12
Beta strandi115 – 118Combined sources4
Helixi120 – 126Combined sources7
Beta strandi127 – 131Combined sources5
Turni134 – 136Combined sources3
Beta strandi138 – 144Combined sources7
Turni145 – 148Combined sources4
Beta strandi149 – 153Combined sources5
Beta strandi157 – 166Combined sources10
Helixi167 – 183Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MP9X-ray2.00A/B2-197[»]
ProteinModelPortaliQ9UWN7.
SMRiQ9UWN7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UWN7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 901Add BLAST77
Repeati105 – 1812Add BLAST77

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG01764. Archaea.
COG2101. LUCA.
HOGENOMiHOG000105163.
KOiK03120.

Family and domain databases

CDDicd04518. TBP_archaea. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR033711. TBP_archaea.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UWN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPDEIPYKA VVNIENIVAT VTLDQTLDLY AMERSVPNVE YDPDQFPGLI
60 70 80 90 100
FRLESPKITS LIFKSGKMVV TGAKSTDELI KAVKRIIKTL KKYGMQLTGK
110 120 130 140 150
PKIQIQNIVA SANLHVIVNL DKAAFLLENN MYEPEQFPGL IYRMDEPRVV
160 170 180 190
LLIFSSGKMV ITGAKREDEV HKAVKKIFDK LVELDCVKPV EEEELEF
Length:197
Mass (Da):22,325
Last modified:May 1, 2000 - v1
Checksum:i187DDF686D4E444B
GO

Sequence cautioni

The sequence AAY80671 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA64405 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94935 Genomic DNA. Translation: CAA64405.1. Different initiation.
AF205428 Genomic DNA. Translation: AAF18138.1.
CP000077 Genomic DNA. Translation: AAY80671.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiAAY80671; AAY80671; Saci_1336.
KEGGisai:Saci_1336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94935 Genomic DNA. Translation: CAA64405.1. Different initiation.
AF205428 Genomic DNA. Translation: AAF18138.1.
CP000077 Genomic DNA. Translation: AAY80671.1. Different initiation.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MP9X-ray2.00A/B2-197[»]
ProteinModelPortaliQ9UWN7.
SMRiQ9UWN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_1336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY80671; AAY80671; Saci_1336.
KEGGisai:Saci_1336.

Phylogenomic databases

eggNOGiarCOG01764. Archaea.
COG2101. LUCA.
HOGENOMiHOG000105163.
KOiK03120.

Miscellaneous databases

EvolutionaryTraceiQ9UWN7.

Family and domain databases

CDDicd04518. TBP_archaea. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR033711. TBP_archaea.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBP_SULAC
AccessioniPrimary (citable) accession number: Q9UWN7
Secondary accession number(s): Q4J956, Q53648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.