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Protein

TATA-box-binding protein

Gene

tbp

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1314-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
Box A-binding protein
Short name:
BAP
TATA sequence-binding protein
Short name:
TBP
TATA-box factor
Gene namesi
Name:tbp
Ordered Locus Names:Saci_1336
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197TATA-box-binding proteinPRO_0000154024Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi330779.Saci_1336.

Structurei

Secondary structure

1
197
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 2212Combined sources
Helixi29 – 357Combined sources
Turni43 – 453Combined sources
Beta strandi47 – 537Combined sources
Turni54 – 574Combined sources
Beta strandi58 – 625Combined sources
Beta strandi66 – 716Combined sources
Helixi76 – 9217Combined sources
Beta strandi102 – 11312Combined sources
Beta strandi115 – 1184Combined sources
Helixi120 – 1267Combined sources
Beta strandi127 – 1315Combined sources
Turni134 – 1363Combined sources
Beta strandi138 – 1447Combined sources
Turni145 – 1484Combined sources
Beta strandi149 – 1535Combined sources
Beta strandi157 – 16610Combined sources
Helixi167 – 18317Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MP9X-ray2.00A/B2-197[»]
ProteinModelPortaliQ9UWN7.
SMRiQ9UWN7. Positions 4-196.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UWN7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati14 – 90771Add
BLAST
Repeati105 – 181772Add
BLAST

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG01764. Archaea.
COG2101. LUCA.
HOGENOMiHOG000105163.
KOiK03120.

Family and domain databases

CDDicd04518. TBP_archaea. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR033711. TBP_archaea.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UWN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPDEIPYKA VVNIENIVAT VTLDQTLDLY AMERSVPNVE YDPDQFPGLI
60 70 80 90 100
FRLESPKITS LIFKSGKMVV TGAKSTDELI KAVKRIIKTL KKYGMQLTGK
110 120 130 140 150
PKIQIQNIVA SANLHVIVNL DKAAFLLENN MYEPEQFPGL IYRMDEPRVV
160 170 180 190
LLIFSSGKMV ITGAKREDEV HKAVKKIFDK LVELDCVKPV EEEELEF
Length:197
Mass (Da):22,325
Last modified:May 1, 2000 - v1
Checksum:i187DDF686D4E444B
GO

Sequence cautioni

The sequence AAY80671 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA64405 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94935 Genomic DNA. Translation: CAA64405.1. Different initiation.
AF205428 Genomic DNA. Translation: AAF18138.1.
CP000077 Genomic DNA. Translation: AAY80671.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiAAY80671; AAY80671; Saci_1336.
KEGGisai:Saci_1336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94935 Genomic DNA. Translation: CAA64405.1. Different initiation.
AF205428 Genomic DNA. Translation: AAF18138.1.
CP000077 Genomic DNA. Translation: AAY80671.1. Different initiation.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MP9X-ray2.00A/B2-197[»]
ProteinModelPortaliQ9UWN7.
SMRiQ9UWN7. Positions 4-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330779.Saci_1336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY80671; AAY80671; Saci_1336.
KEGGisai:Saci_1336.

Phylogenomic databases

eggNOGiarCOG01764. Archaea.
COG2101. LUCA.
HOGENOMiHOG000105163.
KOiK03120.

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1314-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9UWN7.

Family and domain databases

CDDicd04518. TBP_archaea. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR033711. TBP_archaea.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBP_SULAC
AccessioniPrimary (citable) accession number: Q9UWN7
Secondary accession number(s): Q4J956, Q53648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.