Q9UWF8 (CPKA_PYRAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carbamate kinase
EC=2.7.2.2

Alternative name(s):
Carbamate kinase-like carbamoylphosphate synthase

Gene names

Name:	cpkA
Synonyms:	cpa
Ordered Locus Names:	PYRAB08820
ORF Names:	PAB0593

Organism

Pyrococcus abyssi (strain GE5 / Orsay) [Complete proteome] [HAMAP]

Taxonomic identifier

272844 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus › Pyrococcus abyssi

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + NH3 + CO2 = ADP + carbamoyl phosphate.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the carbamate kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	arginine metabolic process Inferred from electronic annotation. Source: InterPro cellular amino acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW carbamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Carbamate kinase		PRO_0000185148

Sequences

	Sequence		Length	Mass (Da)
	Q9UWF8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 85DED48E6A01A8B2	FASTA	314	34,355
	10 20 30 40 50 60 MPERVVIALG GNALQQRGQK GTYEEMMENV KKTAKQIAEI IARGYEVVIT HGNGPQVGTI 70 80 90 100 110 120 LLHMDAGQSL HGIPAQPMDV AGAMSQGWIG YMIQQALRNE LRKRGIEREV VTIVTQTIVD 130 140 150 160 170 180 KDDPAFENPT KPVGPFYDEE TAKKLAKEKG WVVKEDAGRG WRRVVPSPDP KRHVEAETIK 190 200 210 220 230 240 KLVEDGVIVI ASGGGGVPVI EEDGEIKGVE AVIDKDLAGE RLAEEVNADI LMILTDVNGA 250 260 270 280 290 300 ALYYGTEKET WLREVKVDEM ERYYQEGHFK AGSMGPKVLA AIRFVKNGGK RAIIAHLEKA 310 VEALEGKTGT QVIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression, and structure analysis of carbamate kinase-like carbamoyl phosphate synthetase from Pyrococcus abyssi." Purcarea C., Herve G., Cunin R., Evans D.R. Extremophiles 5:229-239(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GE5 / Orsay.
[2]	"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi." Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P. Mol. Microbiol. 47:1495-1512(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GE5 / Orsay.
[3]	"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638." Gao J., Wang J. Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: GE5 / Orsay.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF081680 Genomic DNA. Translation: AAF23075.1. AJ248285 Genomic DNA. Translation: CAB49796.1. HE613800 Genomic DNA. Translation: CCE70288.1.
PIR	C75135.
RefSeq	NP_126565.1. NC_000868.1.
3D structure databases
ProteinModelPortal	Q9UWF8.
SMR	Q9UWF8. Positions 3-314.
ModBase	Search...
Protein-protein interaction databases
STRING	272844.PAB0593.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB49796; CAB49796; PAB0593.
GeneID	1496232.
KEGG	pab:PAB0593.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0549.
HOGENOM	HOG000277403.
KO	K00926.
OMA	ADIFMIL.
ProtClustDB	PRK12454.
Enzyme and pathway databases
BRENDA	6.3.4.16. 5242.
Family and domain databases
Gene3D	3.40.1160.10. 1 hit.
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR003964. Bac_carb_kinase. IPR023000. Shikimate_kinase_CS. [Graphical view]
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000723. Carbamate_kin. 1 hit.
PRINTS	PR01469. CARBMTKINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00746. arcC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CPKA_PYRAB

Accession

Primary (citable) accession number: Q9UWF8
Secondary accession number(s): G8ZI47

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program