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Q9UWF6

- PLB1_CANAL

UniProt

Q9UWF6 - PLB1_CANAL

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Protein

Lysophospholipase 1

Gene

PLB1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: CGD
  2. phospholipase A2 activity Source: CGD

GO - Biological processi

  1. migration in host Source: CGD
  2. pathogenesis Source: CGD
  3. phospholipid catabolic process Source: InterPro
  4. phospholipid metabolic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 1 (EC:3.1.1.5)
Alternative name(s):
CaPLB1
Phospholipase B 1
Gene namesi
Name:PLB1
Synonyms:PLB
ORF Names:CaO19.689
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0001144. PLB1.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. anchored component of plasma membrane Source: CGD
  2. cell surface Source: CGD
  3. extracellular region Source: CGD
  4. fungal-type cell wall Source: CGD
  5. hyphal cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 605588Lysophospholipase 1PRO_0000024630Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi399 – 3991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi573 – 5731N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0001144.

Structurei

3D structure databases

ProteinModelPortaliQ9UWF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 565536PLA2cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG259024.
InParanoidiQ9UWF6.
KOiK13333.
OrthoDBiEOG7N37NC.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UWF6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILHHLLILL IINYCVATSP TNGYAPGPVS CPSSQLIRSG SQGINPNEQS
60 70 80 90 100
YINARYPIAK QALSKFLHNA NLQNFDVDSF LAHSNPTIGL AFSGGGYRAM
110 120 130 140 150
LTGAGEISSL DSRTKTNTPV LAGILQASSY IAGLSGGSWL VGSLASNNLN
160 170 180 190 200
SVDDMLSQGL WELTHSFLSY YGIEHPIKQV EEWVNVGNQV ASKRNANFNV
210 220 230 240 250
SLTDIYGRLL SYPLLTNTED EGDAYLWSDV TSASNFQSHQ MPFPILISDG
260 270 280 290 300
RAPDTTIINL NSTVIELTPY EFGSWDPSLN EFVDTRYLGT KLDNGRPTGK
310 320 330 340 350
CYNGFDNAGF FMGTSSALFN EAVLSITEAN IPSFLKDIID DILVDPILKS
360 370 380 390 400
NIDVSAYNPN PFFKSSGSNT AISQSKNLYL VDGGEDGQNI PISPLLHRNV
410 420 430 440 450
SAIFAFDNSN DVLNWPDGTS LVKTYERQFS SQGNGIAFPY VPDQYTFRNL
460 470 480 490 500
NLTSKPTFFG CDAKNLTSLT KDIYDVPLVI YLANRPFTYW SNTSTFKLTY
510 520 530 540 550
DDNERQGMIS NGFEIATRSS GSLDDEWAAC VGCAIIRREQ ERQGIEQTEQ
560 570 580 590 600
CKRCFENYCW DGTIYKGEPL GENFSDDGLT NSATEYNSNN VAGFNDGGTS

ILKKA
Length:605
Mass (Da):66,417
Last modified:May 1, 2000 - v1
Checksum:i2222F8342379F60C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti471 – 4711K → N in AAC72296. (PubMed:9809417)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59710 Genomic DNA. Translation: AAC61890.1.
AF045558 Genomic DNA. Translation: AAC72296.1.
AACQ01000117 Genomic DNA. Translation: EAK94720.1.
RefSeqiXP_713822.1. XM_708729.1.

Genome annotation databases

GeneIDi3644561.
KEGGical:CaO19.689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59710 Genomic DNA. Translation: AAC61890.1 .
AF045558 Genomic DNA. Translation: AAC72296.1 .
AACQ01000117 Genomic DNA. Translation: EAK94720.1 .
RefSeqi XP_713822.1. XM_708729.1.

3D structure databases

ProteinModelPortali Q9UWF6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0001144.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3644561.
KEGGi cal:CaO19.689.

Organism-specific databases

CGDi CAL0001144. PLB1.

Phylogenomic databases

eggNOGi NOG259024.
InParanoidi Q9UWF6.
KOi K13333.
OrthoDBi EOG7N37NC.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans."
    Leidich S.D., Ibrahim A.S., Fu Y., Koul A., Jessup C., Vitullo J., Fonzi W., Mirbod F., Nakashima S., Nozawa Y., Ghannoum M.A.
    J. Biol. Chem. 273:26078-26086(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: SC5314 / ATCC MYA-2876.
  2. "Cloning and regulated expression of the Candida albicans phospholipase B (PLB1) gene."
    Hoover C.I., Jantapour M.J., Newport G., Agabian N., Fisher S.J.
    FEMS Microbiol. Lett. 167:163-169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SS.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPLB1_CANAL
AccessioniPrimary (citable) accession number: Q9UWF6
Secondary accession number(s): O74207, Q59W35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3