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Protein

Lysophospholipase 1

Gene

PLB1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids (By similarity). Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection (PubMed:9748287).By similarity1 Publication

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

GO - Molecular functioni

  • lysophospholipase activity Source: CGD

GO - Biological processi

  • migration in host Source: CGD
  • pathogenesis Source: CGD
  • phospholipid catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 1 (EC:3.1.1.5By similarity)
Alternative name(s):
CaPLB1
Phospholipase B 1
Gene namesi
Name:PLB11 Publication
Synonyms:PLB
Ordered Locus Names:CAALFM_C601990WA
ORF Names:CaO19.689
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 6

Organism-specific databases

CGDiCAL0000177213 PLB1
EuPathDBiFungiDB:C6_01990W_A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Reduces dramatically the ability to penetrate host cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002463018 – 605Lysophospholipase 1Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi399N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi573N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

Expressed during candidal infection of mice.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9UWF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 565PLA2cPROSITE-ProRule annotationAdd BLAST536

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ9UWF6
KOiK13333
OMAiASKRNAN
OrthoDBiEOG092C2IZ9

Family and domain databases

InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR002642 LysoPLipase_cat_dom
PfamiView protein in Pfam
PF01735 PLA2_B, 1 hit
SMARTiView protein in SMART
SM00022 PLAc, 1 hit
SUPFAMiSSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS51210 PLA2C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UWF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILHHLLILL IINYCVATSP TNGYAPGPVS CPSSQLIRSG SQGINPNEQS
60 70 80 90 100
YINARYPIAK QALSKFLHNA NLQNFDVDSF LAHSNPTIGL AFSGGGYRAM
110 120 130 140 150
LTGAGEISSL DSRTKTNTPV LAGILQASSY IAGLSGGSWL VGSLASNNLN
160 170 180 190 200
SVDDMLSQGL WELTHSFLSY YGIEHPIKQV EEWVNVGNQV ASKRNANFNV
210 220 230 240 250
SLTDIYGRLL SYPLLTNTED EGDAYLWSDV TSASNFQSHQ MPFPILISDG
260 270 280 290 300
RAPDTTIINL NSTVIELTPY EFGSWDPSLN EFVDTRYLGT KLDNGRPTGK
310 320 330 340 350
CYNGFDNAGF FMGTSSALFN EAVLSITEAN IPSFLKDIID DILVDPILKS
360 370 380 390 400
NIDVSAYNPN PFFKSSGSNT AISQSKNLYL VDGGEDGQNI PISPLLHRNV
410 420 430 440 450
SAIFAFDNSN DVLNWPDGTS LVKTYERQFS SQGNGIAFPY VPDQYTFRNL
460 470 480 490 500
NLTSKPTFFG CDAKNLTSLT KDIYDVPLVI YLANRPFTYW SNTSTFKLTY
510 520 530 540 550
DDNERQGMIS NGFEIATRSS GSLDDEWAAC VGCAIIRREQ ERQGIEQTEQ
560 570 580 590 600
CKRCFENYCW DGTIYKGEPL GENFSDDGLT NSATEYNSNN VAGFNDGGTS

ILKKA
Length:605
Mass (Da):66,417
Last modified:May 1, 2000 - v1
Checksum:i2222F8342379F60C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti471K → N in AAC72296 (PubMed:9809417).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59710 Genomic DNA Translation: AAC61890.1
AF045558 Genomic DNA Translation: AAC72296.1
CP017628 Genomic DNA Translation: AOW30135.1
RefSeqiXP_713822.1, XM_708729.2

Genome annotation databases

EnsemblFungiiAOW30135; AOW30135; CAALFM_C601990WA
GeneIDi3644561
KEGGical:CAALFM_C601990WA

Similar proteinsi

Entry informationi

Entry nameiPLB1_CANAL
AccessioniPrimary (citable) accession number: Q9UWF6
Secondary accession number(s): A0A1D8PPS3, O74207, Q59W35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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