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Q9UWF6 (PLB1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase 1

EC=3.1.1.5
Alternative name(s):
CaPLB1
Phospholipase B 1
Gene names
Name:PLB1
Synonyms:PLB
ORF Names:CaO19.689
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length605 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the lysophospholipase family.

Contains 1 PLA2c domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 605588Lysophospholipase 1
PRO_0000024630

Regions

Domain30 – 565536PLA2c

Amino acid modifications

Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation3991N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential
Glycosylation4651N-linked (GlcNAc...) Potential
Glycosylation4921N-linked (GlcNAc...) Potential
Glycosylation5731N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict4711K → N in AAC72296. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9UWF6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 2222F8342379F60C

FASTA60566,417
        10         20         30         40         50         60 
MILHHLLILL IINYCVATSP TNGYAPGPVS CPSSQLIRSG SQGINPNEQS YINARYPIAK 

        70         80         90        100        110        120 
QALSKFLHNA NLQNFDVDSF LAHSNPTIGL AFSGGGYRAM LTGAGEISSL DSRTKTNTPV 

       130        140        150        160        170        180 
LAGILQASSY IAGLSGGSWL VGSLASNNLN SVDDMLSQGL WELTHSFLSY YGIEHPIKQV 

       190        200        210        220        230        240 
EEWVNVGNQV ASKRNANFNV SLTDIYGRLL SYPLLTNTED EGDAYLWSDV TSASNFQSHQ 

       250        260        270        280        290        300 
MPFPILISDG RAPDTTIINL NSTVIELTPY EFGSWDPSLN EFVDTRYLGT KLDNGRPTGK 

       310        320        330        340        350        360 
CYNGFDNAGF FMGTSSALFN EAVLSITEAN IPSFLKDIID DILVDPILKS NIDVSAYNPN 

       370        380        390        400        410        420 
PFFKSSGSNT AISQSKNLYL VDGGEDGQNI PISPLLHRNV SAIFAFDNSN DVLNWPDGTS 

       430        440        450        460        470        480 
LVKTYERQFS SQGNGIAFPY VPDQYTFRNL NLTSKPTFFG CDAKNLTSLT KDIYDVPLVI 

       490        500        510        520        530        540 
YLANRPFTYW SNTSTFKLTY DDNERQGMIS NGFEIATRSS GSLDDEWAAC VGCAIIRREQ 

       550        560        570        580        590        600 
ERQGIEQTEQ CKRCFENYCW DGTIYKGEPL GENFSDDGLT NSATEYNSNN VAGFNDGGTS 


ILKKA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans."
Leidich S.D., Ibrahim A.S., Fu Y., Koul A., Jessup C., Vitullo J., Fonzi W., Mirbod F., Nakashima S., Nozawa Y., Ghannoum M.A.
J. Biol. Chem. 273:26078-26086(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
Strain: SC5314 / ATCC MYA-2876.
[2]"Cloning and regulated expression of the Candida albicans phospholipase B (PLB1) gene."
Hoover C.I., Jantapour M.J., Newport G., Agabian N., Fisher S.J.
FEMS Microbiol. Lett. 167:163-169(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SS.
[3]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59710 Genomic DNA. Translation: AAC61890.1.
AF045558 Genomic DNA. Translation: AAC72296.1.
AACQ01000117 Genomic DNA. Translation: EAK94720.1.
RefSeqXP_713822.1. XM_708729.1.

3D structure databases

ProteinModelPortalQ9UWF6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0001144.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3644561.
KEGGcal:CaO19.689.

Organism-specific databases

CGDCAL0001144. PLB1.

Phylogenomic databases

eggNOGNOG259024.
KOK13333.
OrthoDBEOG7N37NC.

Family and domain databases

InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 1 hit.
PROSITEPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLB1_CANAL
AccessionPrimary (citable) accession number: Q9UWF6
Secondary accession number(s): O74207, Q59W35
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names