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Q9UWF6

- PLB1_CANAL

UniProt

Q9UWF6 - PLB1_CANAL

Protein

Lysophospholipase 1

Gene

PLB1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    GO - Molecular functioni

    1. lysophospholipase activity Source: CGD
    2. phospholipase A2 activity Source: CGD

    GO - Biological processi

    1. migration in host Source: CGD
    2. pathogenesis Source: CGD
    3. phospholipid catabolic process Source: InterPro
    4. phospholipid metabolic process Source: CGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase 1 (EC:3.1.1.5)
    Alternative name(s):
    CaPLB1
    Phospholipase B 1
    Gene namesi
    Name:PLB1
    Synonyms:PLB
    ORF Names:CaO19.689
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0001144. PLB1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: CGD
    2. cell surface Source: CGD
    3. extracellular region Source: CGD
    4. fungal-type cell wall Source: CGD
    5. hyphal cell wall Source: CGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 605588Lysophospholipase 1PRO_0000024630Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi399 – 3991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi573 – 5731N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0001144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UWF6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 565536PLA2cPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lysophospholipase family.Curated
    Contains 1 PLA2c domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG259024.
    KOiK13333.
    OrthoDBiEOG7N37NC.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view]
    PfamiPF01735. PLA2_B. 1 hit.
    [Graphical view]
    SMARTiSM00022. PLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.
    PROSITEiPS51210. PLA2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UWF6-1 [UniParc]FASTAAdd to Basket

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    MILHHLLILL IINYCVATSP TNGYAPGPVS CPSSQLIRSG SQGINPNEQS    50
    YINARYPIAK QALSKFLHNA NLQNFDVDSF LAHSNPTIGL AFSGGGYRAM 100
    LTGAGEISSL DSRTKTNTPV LAGILQASSY IAGLSGGSWL VGSLASNNLN 150
    SVDDMLSQGL WELTHSFLSY YGIEHPIKQV EEWVNVGNQV ASKRNANFNV 200
    SLTDIYGRLL SYPLLTNTED EGDAYLWSDV TSASNFQSHQ MPFPILISDG 250
    RAPDTTIINL NSTVIELTPY EFGSWDPSLN EFVDTRYLGT KLDNGRPTGK 300
    CYNGFDNAGF FMGTSSALFN EAVLSITEAN IPSFLKDIID DILVDPILKS 350
    NIDVSAYNPN PFFKSSGSNT AISQSKNLYL VDGGEDGQNI PISPLLHRNV 400
    SAIFAFDNSN DVLNWPDGTS LVKTYERQFS SQGNGIAFPY VPDQYTFRNL 450
    NLTSKPTFFG CDAKNLTSLT KDIYDVPLVI YLANRPFTYW SNTSTFKLTY 500
    DDNERQGMIS NGFEIATRSS GSLDDEWAAC VGCAIIRREQ ERQGIEQTEQ 550
    CKRCFENYCW DGTIYKGEPL GENFSDDGLT NSATEYNSNN VAGFNDGGTS 600
    ILKKA 605
    Length:605
    Mass (Da):66,417
    Last modified:May 1, 2000 - v1
    Checksum:i2222F8342379F60C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti471 – 4711K → N in AAC72296. (PubMed:9809417)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59710 Genomic DNA. Translation: AAC61890.1.
    AF045558 Genomic DNA. Translation: AAC72296.1.
    AACQ01000117 Genomic DNA. Translation: EAK94720.1.
    RefSeqiXP_713822.1. XM_708729.1.

    Genome annotation databases

    GeneIDi3644561.
    KEGGical:CaO19.689.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59710 Genomic DNA. Translation: AAC61890.1 .
    AF045558 Genomic DNA. Translation: AAC72296.1 .
    AACQ01000117 Genomic DNA. Translation: EAK94720.1 .
    RefSeqi XP_713822.1. XM_708729.1.

    3D structure databases

    ProteinModelPortali Q9UWF6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0001144.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3644561.
    KEGGi cal:CaO19.689.

    Organism-specific databases

    CGDi CAL0001144. PLB1.

    Phylogenomic databases

    eggNOGi NOG259024.
    KOi K13333.
    OrthoDBi EOG7N37NC.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view ]
    Pfami PF01735. PLA2_B. 1 hit.
    [Graphical view ]
    SMARTi SM00022. PLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    PROSITEi PS51210. PLA2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans."
      Leidich S.D., Ibrahim A.S., Fu Y., Koul A., Jessup C., Vitullo J., Fonzi W., Mirbod F., Nakashima S., Nozawa Y., Ghannoum M.A.
      J. Biol. Chem. 273:26078-26086(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
      Strain: SC5314 / ATCC MYA-2876.
    2. "Cloning and regulated expression of the Candida albicans phospholipase B (PLB1) gene."
      Hoover C.I., Jantapour M.J., Newport G., Agabian N., Fisher S.J.
      FEMS Microbiol. Lett. 167:163-169(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SS.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiPLB1_CANAL
    AccessioniPrimary (citable) accession number: Q9UWF6
    Secondary accession number(s): O74207, Q59W35
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3