Q9UWF0 (CALM_MAGO7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calmodulin
Short name=CaM

Gene names

Name:	CMD1
ORF Names:	MGG_06884

Organism

Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome]

Taxonomic identifier

242507 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Magnaporthales › Magnaporthaceae › Magnaporthe › Magnaporthe oryzae

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases By similarity.
Miscellaneous	This protein has four functional calcium-binding sites.
Sequence similarities	Belongs to the calmodulin family. Contains 4 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	mycelium development Inferred from expression pattern PubMed 17156450. Source: PAMGO_MGG
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 149	148	Calmodulin		PRO_0000198320
Regions
	Domain	8 – 43	36	EF-hand 1
	Domain	44 – 79	36	EF-hand 2
	Domain	81 – 116	36	EF-hand 3
	Domain	117 – 149	33	EF-hand 4
	Calcium binding	21 – 32	12	1
	Calcium binding	57 – 68	12	2
	Calcium binding	94 – 105	12	3
	Calcium binding	130 – 141	12	4
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
Natural variations
	Natural variant	92	1	V → F in strain: Guyane 11.
Experimental info
	Sequence conflict	15	1	E → K in AAC96324. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9UWF0 [UniParc]. Last modified June 12, 2007. Version 4. Checksum: 391C14BA2C533A89	FASTA	149	16,997
	10 20 30 40 50 60 MADSLTEEQV SEFKEAFSLF DKDGDGQITT KELGTVMRSL GQNPSESELQ DMINEVDADN 70 80 90 100 110 120 NGTIDFPEFL TMMARKMKDT DSEEEIREAF KVFDRDNNGF ISAAELRHVM TSIGEKLTDD 130 140 EVDEMIREAD QDGDGRIDYN EFVQLMMQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Early expression of the calmodulin gene, which precedes appressorium formation in Magnaporthe grisea, is inhibited by self-inhibitors and requires surface attachment." Liu Z.-M., Kolattukudy P.E. J. Bacteriol. 181:3571-3577(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Guyane 11.
[2]	"Magnaporthe grisea calmodulin gene sequence." Kim Y., Lee Y.-H. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.
[3]	"The genome sequence of the rice blast fungus Magnaporthe grisea." Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K., Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D., Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S., Soanes D.M. , Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W. Nature 434:980-986(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF103729 Genomic DNA. Translation: AAD25331.1. AF089808 Genomic DNA. Translation: AAG00262.1. AF104986 Genomic DNA. Translation: AAC96324.1. CM001231 Genomic DNA. Translation: EHA57001.1.
RefSeq	XP_003709613.1. XM_003709565.1.
3D structure databases
ProteinModelPortal	Q9UWF0.
SMR	Q9UWF0. Positions 3-146.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	MGG_16201T0; MGG_16201T0; MGG_16201.
GeneID	12985220.
KEGG	mgr:MGG_16201.
Phylogenomic databases
OrthoDB	EOG4WQ4C0.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR001125. Recoverin. [Graphical view]
Pfam	PF13499. EF_hand_5. 2 hits. [Graphical view]
PRINTS	PR00450. RECOVERIN.
SMART	SM00054. EFh. 4 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 4 hits. PS50222. EF_HAND_2. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CALM_MAGO7

Accession

Primary (citable) accession number: Q9UWF0
Secondary accession number(s): A4R1M4, G4MMX9, O93930

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 88 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program