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Q9UW86

- PP1_NEUCR

UniProt

Q9UW86 - PP1_NEUCR

Protein

Serine/threonine-protein phosphatase PP1

Gene

pph-3

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi64 – 641Manganese 1By similarity
    Metal bindingi66 – 661Manganese 1By similarity
    Metal bindingi92 – 921Manganese 1By similarity
    Metal bindingi92 – 921Manganese 2By similarity
    Metal bindingi124 – 1241Manganese 2By similarity
    Active sitei125 – 1251Proton donorBy similarity
    Metal bindingi173 – 1731Manganese 2By similarity
    Metal bindingi248 – 2481Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: EnsemblFungi

    GO - Biological processi

    1. ascospore formation Source: EnsemblFungi
    2. cell budding Source: EnsemblFungi
    3. cellular ion homeostasis Source: EnsemblFungi
    4. chromosome segregation Source: EnsemblFungi
    5. DNA damage checkpoint Source: EnsemblFungi
    6. DNA replication checkpoint Source: EnsemblFungi
    7. glycogen metabolic process Source: EnsemblFungi
    8. histone dephosphorylation Source: EnsemblFungi
    9. meiotic nuclear division Source: EnsemblFungi
    10. mitotic spindle assembly checkpoint Source: EnsemblFungi
    11. protein localization to kinetochore Source: EnsemblFungi
    12. regulation of carbohydrate metabolic process Source: EnsemblFungi
    13. regulation of cell shape during vegetative growth phase Source: EnsemblFungi
    14. replication fork processing Source: EnsemblFungi
    15. response to heat Source: EnsemblFungi
    16. rRNA processing Source: EnsemblFungi
    17. termination of RNA polymerase II transcription, exosome-dependent Source: EnsemblFungi
    18. termination of RNA polymerase II transcription, poly(A)-coupled Source: EnsemblFungi

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1 (EC:3.1.3.16)
    Alternative name(s):
    Phosphoprotein phosphatase 1
    Gene namesi
    Name:pph-3
    Synonyms:ppp-1
    ORF Names:NCU00043
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 3, Linkage Group III

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cellular bud neck Source: EnsemblFungi
    2. condensed nuclear chromosome kinetochore Source: EnsemblFungi
    3. mating projection base Source: EnsemblFungi
    4. mRNA cleavage and polyadenylation specificity factor complex Source: EnsemblFungi
    5. nucleolus Source: EnsemblFungi
    6. protein phosphatase type 1 complex Source: EnsemblFungi
    7. spindle pole body Source: EnsemblFungi

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Serine/threonine-protein phosphatase PP1PRO_0000058817Add
    BLAST

    Proteomic databases

    PRIDEiQ9UW86.

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU00043.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UW86.
    SMRiQ9UW86. Positions 1-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172697.
    KOiK06269.
    OrthoDBiEOG79KPQ9.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UW86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADHTEVDLD SIIDRLLEVR GSRPGKQVQL LEAEIRYLCT KAREIFISQP    50
    ILLELEAPIK ICGDIHGQYY DLLRLFEYGG FPPEANYLFL GDYVDRGKQS 100
    LETICLLLAY KIKYPENFFI LRGNHECASI NRIYGFYDEC KRRYNIKLWK 150
    TFTDCFNCLP IAAIIDEKIF TMHGGLSPDL NSMEQIRRVM RPTDIPDCGL 200
    LCDLLWSDPD KDITGWSEND RGVSFTFGPD VVSRFLQKHD MDLICRAHQV 250
    VEDGYEFFSK RQLVTLFSAP NYCGEFDNAG AMMSVDESLL CSFQILKPAE 300
    KKQKFGRR 308
    Length:308
    Mass (Da):35,568
    Last modified:May 1, 2000 - v1
    Checksum:i333A728F20860AB1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541D → E in AAC05275. (PubMed:12524044)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049853 mRNA. Translation: AAC05275.1.
    AF124149 Genomic DNA. Translation: AAD47567.1.
    CM002238 Genomic DNA. Translation: EAA26918.2.
    RefSeqiXP_956154.2. XM_951061.2.
    UniGeneiNcr.4075.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000000314; EFNCRP00000000314; EFNCRG00000000314.
    GeneIDi3872306.
    KEGGincr:NCU00043.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049853 mRNA. Translation: AAC05275.1 .
    AF124149 Genomic DNA. Translation: AAD47567.1 .
    CM002238 Genomic DNA. Translation: EAA26918.2 .
    RefSeqi XP_956154.2. XM_951061.2.
    UniGenei Ncr.4075.

    3D structure databases

    ProteinModelPortali Q9UW86.
    SMRi Q9UW86. Positions 1-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU00043.1.

    Proteomic databases

    PRIDEi Q9UW86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000000314 ; EFNCRP00000000314 ; EFNCRG00000000314 .
    GeneIDi 3872306.
    KEGGi ncr:NCU00043.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172697.
    KOi K06269.
    OrthoDBi EOG79KPQ9.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    2. "Expression of protein phosphatase 1 during the asexual development of Neurospora crassa."
      Zeke T., Kokai E., Szoor B., Yatzkan E., Yarden O., Szirak K., Feher Z., Bagossi P., Gergely P., Dombradi V.
      Comp. Biochem. Physiol. 134B:161-170(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 74-OR23-1VA / FGSC 2489.
    3. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiPP1_NEUCR
    AccessioniPrimary (citable) accession number: Q9UW86
    Secondary accession number(s): O59927, Q7RV51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3