Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UW86

- PP1_NEUCR

UniProt

Q9UW86 - PP1_NEUCR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Serine/threonine-protein phosphatase PP1

Gene

pph-3

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Manganese 1By similarity
Metal bindingi66 – 661Manganese 1By similarity
Metal bindingi92 – 921Manganese 1By similarity
Metal bindingi92 – 921Manganese 2By similarity
Metal bindingi124 – 1241Manganese 2By similarity
Active sitei125 – 1251Proton donorBy similarity
Metal bindingi173 – 1731Manganese 2By similarity
Metal bindingi248 – 2481Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: EnsemblFungi

GO - Biological processi

  1. ascospore formation Source: EnsemblFungi
  2. cell budding Source: EnsemblFungi
  3. cellular ion homeostasis Source: EnsemblFungi
  4. chromosome segregation Source: EnsemblFungi
  5. DNA damage checkpoint Source: EnsemblFungi
  6. DNA replication checkpoint Source: EnsemblFungi
  7. glycogen metabolic process Source: EnsemblFungi
  8. histone dephosphorylation Source: EnsemblFungi
  9. meiotic nuclear division Source: EnsemblFungi
  10. mitotic spindle assembly checkpoint Source: EnsemblFungi
  11. protein localization to kinetochore Source: EnsemblFungi
  12. regulation of carbohydrate metabolic process Source: EnsemblFungi
  13. regulation of cell shape during vegetative growth phase Source: EnsemblFungi
  14. replication fork processing Source: EnsemblFungi
  15. response to heat Source: EnsemblFungi
  16. rRNA processing Source: EnsemblFungi
  17. termination of RNA polymerase II transcription, exosome-dependent Source: EnsemblFungi
  18. termination of RNA polymerase II transcription, poly(A)-coupled Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 (EC:3.1.3.16)
Alternative name(s):
Phosphoprotein phosphatase 1
Gene namesi
Name:pph-3
Synonyms:ppp-1
ORF Names:NCU00043
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 3, Linkage Group III

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cellular bud neck Source: EnsemblFungi
  2. condensed nuclear chromosome kinetochore Source: EnsemblFungi
  3. mating projection base Source: EnsemblFungi
  4. mRNA cleavage and polyadenylation specificity factor complex Source: EnsemblFungi
  5. nucleolus Source: EnsemblFungi
  6. protein phosphatase type 1 complex Source: EnsemblFungi
  7. spindle pole body Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Serine/threonine-protein phosphatase PP1PRO_0000058817Add
BLAST

Proteomic databases

PRIDEiQ9UW86.

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU00043.1.

Structurei

3D structure databases

ProteinModelPortaliQ9UW86.
SMRiQ9UW86. Positions 1-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172697.
InParanoidiQ9UW86.
KOiK06269.
OrthoDBiEOG79KPQ9.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UW86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADHTEVDLD SIIDRLLEVR GSRPGKQVQL LEAEIRYLCT KAREIFISQP
60 70 80 90 100
ILLELEAPIK ICGDIHGQYY DLLRLFEYGG FPPEANYLFL GDYVDRGKQS
110 120 130 140 150
LETICLLLAY KIKYPENFFI LRGNHECASI NRIYGFYDEC KRRYNIKLWK
160 170 180 190 200
TFTDCFNCLP IAAIIDEKIF TMHGGLSPDL NSMEQIRRVM RPTDIPDCGL
210 220 230 240 250
LCDLLWSDPD KDITGWSEND RGVSFTFGPD VVSRFLQKHD MDLICRAHQV
260 270 280 290 300
VEDGYEFFSK RQLVTLFSAP NYCGEFDNAG AMMSVDESLL CSFQILKPAE

KKQKFGRR
Length:308
Mass (Da):35,568
Last modified:May 1, 2000 - v1
Checksum:i333A728F20860AB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541D → E in AAC05275. (PubMed:12524044)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049853 mRNA. Translation: AAC05275.1.
AF124149 Genomic DNA. Translation: AAD47567.1.
CM002238 Genomic DNA. Translation: EAA26918.2.
RefSeqiXP_956154.2. XM_951061.2.
UniGeneiNcr.4075.

Genome annotation databases

EnsemblFungiiEFNCRT00000000314; EFNCRP00000000314; EFNCRG00000000314.
GeneIDi3872306.
KEGGincr:NCU00043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049853 mRNA. Translation: AAC05275.1 .
AF124149 Genomic DNA. Translation: AAD47567.1 .
CM002238 Genomic DNA. Translation: EAA26918.2 .
RefSeqi XP_956154.2. XM_951061.2.
UniGenei Ncr.4075.

3D structure databases

ProteinModelPortali Q9UW86.
SMRi Q9UW86. Positions 1-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU00043.1.

Proteomic databases

PRIDEi Q9UW86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000000314 ; EFNCRP00000000314 ; EFNCRG00000000314 .
GeneIDi 3872306.
KEGGi ncr:NCU00043.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172697.
InParanoidi Q9UW86.
KOi K06269.
OrthoDBi EOG79KPQ9.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "Expression of protein phosphatase 1 during the asexual development of Neurospora crassa."
    Zeke T., Kokai E., Szoor B., Yatzkan E., Yarden O., Szirak K., Feher Z., Bagossi P., Gergely P., Dombradi V.
    Comp. Biochem. Physiol. 134B:161-170(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 74-OR23-1VA / FGSC 2489.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiPP1_NEUCR
AccessioniPrimary (citable) accession number: Q9UW86
Secondary accession number(s): O59927, Q7RV51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3