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Q9UW26

- PAPA_CANAL

UniProt

Q9UW26 - PAPA_CANAL

Protein

Poly(A) polymerase PAPa

Gene

PAPA

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor By similarity.By similarity

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Cofactori

    Binds 2 magnesium ions. Also active with manganese By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi99 – 991Magnesium 1; catalyticBy similarity
    Metal bindingi99 – 991Magnesium 2; catalyticBy similarity
    Metal bindingi101 – 1011Magnesium 1; catalyticBy similarity
    Metal bindingi101 – 1011Magnesium 2; catalyticBy similarity
    Sitei139 – 1391Interaction with RNABy similarity
    Sitei144 – 1441Interaction with RNABy similarity
    Metal bindingi153 – 1531Magnesium 2; catalyticBy similarity
    Binding sitei153 – 1531ATPBy similarity
    Binding sitei214 – 2141ATPBy similarity
    Binding sitei223 – 2231ATPBy similarity
    Sitei313 – 3131Interaction with RNABy similarity
    Sitei314 – 3141Interaction with RNABy similarity
    Sitei386 – 3861Interaction with RNABy similarity
    Sitei391 – 3911Interaction with RNABy similarity
    Sitei487 – 4871Interaction with RNABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi86 – 883ATPBy similarity
    Nucleotide bindingi99 – 1013ATPBy similarity
    Nucleotide bindingi232 – 2332ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. polynucleotide adenylyltransferase activity Source: CGD
    4. RNA binding Source: CGD

    GO - Biological processi

    1. mRNA polyadenylation Source: CGD
    2. single-species biofilm formation on inanimate substrate Source: CGD

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase PAPa (EC:2.7.7.19)
    Alternative name(s):
    Polynucleotide adenylyltransferase a
    Gene namesi
    Name:PAPA
    Synonyms:PAP99
    ORF Names:CaO19.3197
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0002451. PAP1.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Poly(A) polymerase PAPaPRO_0000051619Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0002451.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UW26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the poly(A) polymerase family.Curated

    Phylogenomic databases

    eggNOGiCOG5186.
    KOiK14376.
    OrthoDBiEOG7M6DHG.

    Family and domain databases

    Gene3Di3.30.70.590. 1 hit.
    InterProiIPR002934. Nucleotidyltransferase.
    IPR011068. NuclTrfase_I_C.
    IPR007012. PolA_pol_cen_dom.
    IPR007010. PolA_pol_RNA-bd_dom.
    IPR014492. PolyA_polymerase.
    [Graphical view]
    PfamiPF01909. NTP_transf_2. 1 hit.
    PF04928. PAP_central. 1 hit.
    PF04926. PAP_RNA-bind. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018425. PolyA_polymerase. 1 hit.
    SUPFAMiSSF55003. SSF55003. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9UW26-1 [UniParc]FASTAAdd to Basket

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    MNNQAYGVTP PISVANSTPK ENELNDSLIK ELKSRGSFES ETATKKRVEV    50
    LNILQSMTEE FVYKVSIKKN ISEGMARDVG GKIFTFGSYR LGVYGPGSDI 100
    DTLVVVPKHV SRNDFFEVFY ELLKGRSELE EIAPVPDAFV PIIKIEFAGI 150
    SIDLIFARLD IPRVPRDLTL DDKNLLKNID EKDLRALNGT RVTDEILQLV 200
    PKPTVFKHAL RCIKMWAQQR AVYGNIFGFP GGVAWAMLVA RICQLYPNAV 250
    SAVIVEKFFH IYSQWAWPQP VLLKQIEDGP LQVRVWNPRL YALDRQHRMP 300
    VITPAYPSMC ATHNITSSTQ KVILSEFQRG IELMNDINVG KKSWSDLLER 350
    HDFFFRYKFY LCIVAATRST YAEHLKYSGM VESKLRLLVQ KLELVEGIEL 400
    AHPYVKSFEN GYYCDNAEEA HEIMNLYGTS KGDDRVKGVL HAENNDNNKE 450
    NVENKVELHM TKLFIGLKLD LSKEGEKKLD IQYPCAEFFN ICKGWQDFDS 500
    EKHFIQIKNV KLYDLSDDVY VDGETRPIKI AKRKRAVSKN EGKKKPKSVG 550
    TVSAA 555
    Length:555
    Mass (Da):63,289
    Last modified:May 1, 2000 - v1
    Checksum:i5C76DA500616042A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti447 – 4471N → K in BAA36217. 1 PublicationCurated
    Sequence conflicti506 – 5061Q → R in BAA36217. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF167162 Genomic DNA. Translation: AAD51407.1.
    AB021667 Genomic DNA. Translation: BAA36217.1.
    AACQ01000100 Genomic DNA. Translation: EAK95563.1.
    RefSeqiXP_714613.1. XM_709520.1.

    Genome annotation databases

    GeneIDi3643763.
    KEGGical:CaO19.3197.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF167162 Genomic DNA. Translation: AAD51407.1 .
    AB021667 Genomic DNA. Translation: BAA36217.1 .
    AACQ01000100 Genomic DNA. Translation: EAK95563.1 .
    RefSeqi XP_714613.1. XM_709520.1.

    3D structure databases

    ProteinModelPortali Q9UW26.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0002451.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3643763.
    KEGGi cal:CaO19.3197.

    Organism-specific databases

    CGDi CAL0002451. PAP1.

    Phylogenomic databases

    eggNOGi COG5186.
    KOi K14376.
    OrthoDBi EOG7M6DHG.

    Family and domain databases

    Gene3Di 3.30.70.590. 1 hit.
    InterProi IPR002934. Nucleotidyltransferase.
    IPR011068. NuclTrfase_I_C.
    IPR007012. PolA_pol_cen_dom.
    IPR007010. PolA_pol_RNA-bd_dom.
    IPR014492. PolyA_polymerase.
    [Graphical view ]
    Pfami PF01909. NTP_transf_2. 1 hit.
    PF04928. PAP_central. 1 hit.
    PF04926. PAP_RNA-bind. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018425. PolyA_polymerase. 1 hit.
    SUPFAMi SSF55003. SSF55003. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans."
      Hull C.M., Johnson A.D.
      Science 285:1271-1275(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Candida albicans PAP99 gene, a putative homolog of the C.albicans PAP1 gene."
      Nagahashi S., Ishii N., Aoki Y., Arisawa M.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiPAPA_CANAL
    AccessioniPrimary (citable) accession number: Q9UW26
    Secondary accession number(s): O93834, Q59YI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3