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Q9UW26

- PAPA_CANAL

UniProt

Q9UW26 - PAPA_CANAL

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Protein

Poly(A) polymerase PAPa

Gene
PAPA, PAP99, CaO19.3197
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor By similarity.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Binds 2 magnesium ions. Also active with manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi99 – 991Magnesium 1; catalytic By similarity
Metal bindingi99 – 991Magnesium 2; catalytic By similarity
Metal bindingi101 – 1011Magnesium 1; catalytic By similarity
Metal bindingi101 – 1011Magnesium 2; catalytic By similarity
Sitei139 – 1391Interaction with RNA By similarity
Sitei144 – 1441Interaction with RNA By similarity
Metal bindingi153 – 1531Magnesium 2; catalytic By similarity
Binding sitei153 – 1531ATP By similarity
Binding sitei214 – 2141ATP By similarity
Binding sitei223 – 2231ATP By similarity
Sitei313 – 3131Interaction with RNA By similarity
Sitei314 – 3141Interaction with RNA By similarity
Sitei386 – 3861Interaction with RNA By similarity
Sitei391 – 3911Interaction with RNA By similarity
Sitei487 – 4871Interaction with RNA By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 883ATP By similarity
Nucleotide bindingi99 – 1013ATP By similarity
Nucleotide bindingi232 – 2332ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. polynucleotide adenylyltransferase activity Source: CGD
  4. RNA binding Source: CGD

GO - Biological processi

  1. mRNA polyadenylation Source: CGD
  2. single-species biofilm formation on inanimate substrate Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase PAPa (EC:2.7.7.19)
Alternative name(s):
Polynucleotide adenylyltransferase a
Gene namesi
Name:PAPA
Synonyms:PAP99
ORF Names:CaO19.3197
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0002451. PAP1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Poly(A) polymerase PAPaPRO_0000051619Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0002451.

Structurei

3D structure databases

ProteinModelPortaliQ9UW26.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5186.
KOiK14376.
OrthoDBiEOG7M6DHG.

Family and domain databases

Gene3Di3.30.70.590. 1 hit.
InterProiIPR002934. Nucleotidyltransferase.
IPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
[Graphical view]
PfamiPF01909. NTP_transf_2. 1 hit.
PF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view]
PIRSFiPIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMiSSF55003. SSF55003. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UW26-1 [UniParc]FASTAAdd to Basket

« Hide

MNNQAYGVTP PISVANSTPK ENELNDSLIK ELKSRGSFES ETATKKRVEV    50
LNILQSMTEE FVYKVSIKKN ISEGMARDVG GKIFTFGSYR LGVYGPGSDI 100
DTLVVVPKHV SRNDFFEVFY ELLKGRSELE EIAPVPDAFV PIIKIEFAGI 150
SIDLIFARLD IPRVPRDLTL DDKNLLKNID EKDLRALNGT RVTDEILQLV 200
PKPTVFKHAL RCIKMWAQQR AVYGNIFGFP GGVAWAMLVA RICQLYPNAV 250
SAVIVEKFFH IYSQWAWPQP VLLKQIEDGP LQVRVWNPRL YALDRQHRMP 300
VITPAYPSMC ATHNITSSTQ KVILSEFQRG IELMNDINVG KKSWSDLLER 350
HDFFFRYKFY LCIVAATRST YAEHLKYSGM VESKLRLLVQ KLELVEGIEL 400
AHPYVKSFEN GYYCDNAEEA HEIMNLYGTS KGDDRVKGVL HAENNDNNKE 450
NVENKVELHM TKLFIGLKLD LSKEGEKKLD IQYPCAEFFN ICKGWQDFDS 500
EKHFIQIKNV KLYDLSDDVY VDGETRPIKI AKRKRAVSKN EGKKKPKSVG 550
TVSAA 555
Length:555
Mass (Da):63,289
Last modified:May 1, 2000 - v1
Checksum:i5C76DA500616042A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti447 – 4471N → K in BAA36217. 1 Publication
Sequence conflicti506 – 5061Q → R in BAA36217. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167162 Genomic DNA. Translation: AAD51407.1.
AB021667 Genomic DNA. Translation: BAA36217.1.
AACQ01000100 Genomic DNA. Translation: EAK95563.1.
RefSeqiXP_714613.1. XM_709520.1.

Genome annotation databases

GeneIDi3643763.
KEGGical:CaO19.3197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167162 Genomic DNA. Translation: AAD51407.1 .
AB021667 Genomic DNA. Translation: BAA36217.1 .
AACQ01000100 Genomic DNA. Translation: EAK95563.1 .
RefSeqi XP_714613.1. XM_709520.1.

3D structure databases

ProteinModelPortali Q9UW26.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0002451.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3643763.
KEGGi cal:CaO19.3197.

Organism-specific databases

CGDi CAL0002451. PAP1.

Phylogenomic databases

eggNOGi COG5186.
KOi K14376.
OrthoDBi EOG7M6DHG.

Family and domain databases

Gene3Di 3.30.70.590. 1 hit.
InterProi IPR002934. Nucleotidyltransferase.
IPR011068. NuclTrfase_I_C.
IPR007012. PolA_pol_cen_dom.
IPR007010. PolA_pol_RNA-bd_dom.
IPR014492. PolyA_polymerase.
[Graphical view ]
Pfami PF01909. NTP_transf_2. 1 hit.
PF04928. PAP_central. 1 hit.
PF04926. PAP_RNA-bind. 1 hit.
[Graphical view ]
PIRSFi PIRSF018425. PolyA_polymerase. 1 hit.
SUPFAMi SSF55003. SSF55003. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans."
    Hull C.M., Johnson A.D.
    Science 285:1271-1275(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Candida albicans PAP99 gene, a putative homolog of the C.albicans PAP1 gene."
    Nagahashi S., Ishii N., Aoki Y., Arisawa M.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiPAPA_CANAL
AccessioniPrimary (citable) accession number: Q9UW26
Secondary accession number(s): O93834, Q59YI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: November 13, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi