Q9UW24 (PIK1A_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 4-kinase PIK1a
Short name=PI4-kinase
Short name=PtdIns-4-kinase
EC=2.7.1.67

Gene names

Name:	PIKA
ORF Names:	CaO19.3199

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	956 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate By similarity.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Subcellular location	Nucleus By similarity.
Miscellaneous	The C.albicans mating-type-like (MTL) locus contains, in addition to the genes for the regulatory proteins (MTLA1, MTLA2, MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA and OBPALPHA).
Sequence similarities	Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Contains 1 PI3K/PI4K domain. Contains 1 PIK helical domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-phosphatidylinositol 4-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 956	956	Phosphatidylinositol 4-kinase PIK1a		PRO_0000088833
Regions
	Domain	1 – 120	120	PIK helical
	Domain	682 – 953	272	PI3K/PI4K

Sequences

	Sequence		Length	Mass (Da)
	Q9UW24 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 940777ECF976C68B	FASTA	956	109,252
	10 20 30 40 50 60 MPVAPHELRD TIKSRDLGLF QCIDLLKQHN DNIGVHHQLV QKLYSYSYDE LEFFIPQFIQ 70 80 90 100 110 120 LLVNFETDSM ALEDFLLHYC NQFPHFSLIV FWYLQAFLFE LRNEPKSYSF QTVRKFINKL 130 140 150 160 170 180 QNILFNVETS FHIRGPEFRE NMQPALILCG SVASAFSSPL VNEYALPIVR SQGKQQKSFV 190 200 210 220 230 240 FKLASFQKSL TRNLTMKNQR LSADAITPVI SDDDSKVSNR IQESQRLKTK YSKKKISAAL 250 260 270 280 290 300 QLDDSENYTT DEEELGYVQT LSRPKIREMK YTEVEENLKI NTIIRSKKNR SKTTVNSISF 310 320 330 340 350 360 FSDTDQSASM EEYNRSAQSL PELVRTRSRL DLYSSESEAA LGTSRNSAEL IISKKKFMGS 370 380 390 400 410 420 EVKTRPYKEL LKILQVNYSK KETSFIMSLQ NISLRLSSVP KVARLSALRA ELSIINESIL 430 440 450 460 470 480 PSEIDIPQLL PVTSNKNKKF HKILKLNINE ACVLNSAERV PYLLLIEYLS DEIDFNPFSD 490 500 510 520 530 540 QNQKIINDCV RKPEVKPNDQ ISGDDDTSVV SSIQEEMFLD NNASENYNED GDLGEISLLH 550 560 570 580 590 600 SRSSSRDWAK STPGSPVARS SQEDEKFYGN VSSTTGGTIE SSVLADQMRI ASLMLQQLES 610 620 630 640 650 660 SGQSNTQQFV SIRNRIIESM ISLQDQFDFI DYETLKELKT DEQDAGKRKL ENDFKLAEDW 670 680 690 700 710 720 NEKKHRIRKS SIYGHLENWD LCSVIVKNGD DLPQEAFACQ LISLISNIWK KHKVDFWTKR 730 740 750 760 770 780 MKILITSANA GLVETITNAM SIHSIKKSLT ELSIENGENA KGRIFTLKDY FQKLYGSVDS 790 800 810 820 830 840 SKYVKAQENF AISLASYSII CYVLQIKDRH NGNIMLDHEG HIIHIDFGFL LSNSPGSVGF 850 860 870 880 890 900 EAAPFKLTSE YVEVLGGLES KAYLKFVDTC KNCFKALRKE WGQIVSIVEL MQKGSSLPCF 910 920 930 940 950 NNGDNTSVLL QQRLQLHLSD EEIDSFIEVY LIEKSVGSMY TRLYDQFQMI TQGIYS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans." Hull C.M., Johnson A.D. Science 285:1271-1275(1999) [PubMed: 10455055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF167162 Genomic DNA. Translation: AAD51405.1. AACQ01000100 Genomic DNA. Translation: EAK95565.1.
RefSeq	XP_714615.1. XM_709522.1.
3D structure databases
ProteinModelPortal	Q9UW24.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UW24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3643765.
KEGG	cal:CaO19.3199.
Organism-specific databases
CGD	CAL0002453. PIKA.
Phylogenomic databases
PhylomeDB	Q9UW24.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR011009. Kinase-like_dom. IPR021601. Phosphatidylinositol_kinase. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR015433. PI_Kinase. IPR001263. PInositide-3_kin_accessory_dom. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit. G3DSA:1.25.40.70. PI3Ka. 1 hit.
KO	K00888.
PANTHER	PTHR10048. PI_Kinase. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. PF11522. Pik1. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00915. PI3_4_KINASE_1. False negative. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. PS51545. PIK_HELICAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PIK1A_CANAL

Accession

Primary (citable) accession number: Q9UW24
Secondary accession number(s): Q59YI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program