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Protein

Thioredoxin

Gene
N/A
Organism
Coprinus comatus (Shaggy mane)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei24Deprotonates C-terminal active site CysBy similarity1
Active sitei30NucleophileBy similarity1
Sitei31Contributes to redox potential valueBy similarity1
Sitei32Contributes to redox potential valueBy similarity1
Active sitei33NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin
Short name:
Trx
Alternative name(s):
Allergen: Cop c 2
OrganismiCoprinus comatus (Shaggy mane)
Taxonomic identifieri56187 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeCoprinus

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei226. Cop c 2.
3210. Cop c 2.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001200381 – 106ThioredoxinAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 33Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ9UW02.
SMRiQ9UW02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 106ThioredoxinPROSITE-ProRule annotationAdd BLAST105

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Family and domain databases

InterProiView protein in InterPro
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiView protein in Pfam
PF00085. Thioredoxin. 1 hit.
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiView protein in PROSITE
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UW02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQVISNLDE FNKLTNSGKI IIIDFWATWC GPCRVISPIF EKFSEKYGAN
60 70 80 90 100
NIVFAKVDVD TASDISEEAK IRAMPTFQVY KDGQKIDELV GANPTALESL

VQKSLA
Length:106
Mass (Da):11,773
Last modified:May 1, 2000 - v1
Checksum:i05A2155B210E8C69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242791 mRNA. Translation: CAB52130.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTHIO_COPCM
AccessioniPrimary (citable) accession number: Q9UW02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 10, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families