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Q9UVZ5

- PYRF_SACFI

UniProt

Q9UVZ5 - PYRF_SACFI

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Saccharomycopsis fibuligera (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371SubstrateBy similarity
Active sitei93 – 931Proton donorPROSITE-ProRule annotation
Binding sitei217 – 2171SubstrateBy similarity
Binding sitei236 – 2361SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiSaccharomycopsis fibuligera (Yeast)
Taxonomic identifieri4944 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycopsidaceaeSaccharomycopsis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Orotidine 5'-phosphate decarboxylasePRO_0000134681Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9UVZ5.
SMRiQ9UVZ5. Positions 1-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 613Substrate bindingBy similarity
Regioni91 – 10010Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UVZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANLTYSERA QKTKSPLVKK LFTIIEEKKT NLCASVDVRS TSQFLDLIEK
60 70 80 90 100
LGPYICVVKT HIDILDDFSY EKTIVPLLEL KKKFNFLIFE DRKFADIGNT
110 120 130 140 150
VKLQYSAGIY KISSWADISN AHGVPGQGIV AGLKQAAQET TQEPRGLLML
160 170 180 190 200
AELSSKGSIA TGEYTEKTID IARSDKEFVV GFIAQRKIEA KDDDEDWVVM
210 220 230 240 250
TPGVGLDDKG DALGQQYRTV SEVVTGAGSD IIIVGRGLIG AGRDPVAEGL
260
RYRKAGWDAY LARLS
Length:265
Mass (Da):29,157
Last modified:May 1, 2000 - v1
Checksum:i5E7E4D914F375460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245745 Genomic DNA. Translation: CAB53393.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245745 Genomic DNA. Translation: CAB53393.1 .

3D structure databases

ProteinModelPortali Q9UVZ5.
SMRi Q9UVZ5. Positions 1-263.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transformation of Endomyces fibuliger based on its gene for orotidine-5'-phosphate decarboxylase."
    Ngan W.Y., Nga B.H., Pridmore R.D., Mollet B., Tan H.M.
    Gene 254:97-103(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 8014 met.

Entry informationi

Entry nameiPYRF_SACFI
AccessioniPrimary (citable) accession number: Q9UVZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3