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Q9UVX3

- NMT_ASPFU

UniProt

Q9UVX3 - NMT_ASPFU

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Protein
Glycylpeptide N-tetradecanoyltransferase
Gene
nmt1, AFUA_4G08070
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei492 – 4921Proton acceptor; via carboxylate By similarity

GO - Molecular functioni

  1. glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. N-terminal protein myristoylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase (EC:2.3.1.97)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase
Short name:
NMT
Peptide N-myristoyltransferase
Gene namesi
Name:nmt1
ORF Names:AFUA_4G08070
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Glycylpeptide N-tetradecanoyltransferase
PRO_0000064235Add
BLAST

Proteomic databases

PRIDEiQ9UVX3.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9UVX3.
SMRiQ9UVX3. Positions 78-492.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 854Myristoyl CoA-binding By similarity
Regioni212 – 24837Myristoyl CoA-binding By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the NMT family.

Phylogenomic databases

eggNOGiCOG5092.
HOGENOMiHOG000189123.
KOiK00671.
OMAiATFRFKY.
OrthoDBiEOG78SQSW.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UVX3-1 [UniParc]FASTAAdd to Basket

« Hide

MSDSKDRKGK APEGQSSEKK DGAVNITPQM AESLLENNPA LRNETAGMDK    50
DKAAEAMRKM NIAELLTGLS VSGKNQKDMA SYKFWQTQPV PRFDETSTDT 100
GGPIKIIDPE KVSKEPDALL EGFEWATLDL TNETELQELW DLLTYHYVED 150
DNAMFRFRYS QSFLHWALMS PGWKKEWHVG VRATKSRKLV ASICGVPTEI 200
NVRNQKLKVV EINFLCIHKK LRSKRLTPVL IKEITRRCYL NGIYQAIYTA 250
GVVLPTPVSS CRYYHRPLDW LKLYEVGFSP LPAGSTKARQ ITKNHLPSTT 300
STPGLRPMEP KDIDTVHDLL QRYLSRFALN QAFTREEVDH WLVHKPETVK 350
EQVVWAYVVE DPETHKITDF FSFYNLESTV IQNPKHDNVR AAYLYYYATE 400
TAFTNNMKAL KERLLMLMND ALILAKKAHF DVFNALTLHD NPLFLEQLKF 450
GAGDGQLHFY LYNYRTAPVP GGVNEKNLPD EKRMGGVGIV ML 492
Length:492
Mass (Da):56,255
Last modified:May 1, 2000 - v1
Checksum:i921C0C5FF805F000
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB035414 mRNA. Translation: BAA87865.1.
AAHF01000005 Genomic DNA. Translation: EAL89981.1.
RefSeqiXP_752019.1. XM_746926.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00007889; CADAFUAP00007889; CADAFUAG00007889.
GeneIDi3508953.
KEGGiafm:AFUA_4G08070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB035414 mRNA. Translation: BAA87865.1 .
AAHF01000005 Genomic DNA. Translation: EAL89981.1 .
RefSeqi XP_752019.1. XM_746926.1.

3D structure databases

ProteinModelPortali Q9UVX3.
SMRi Q9UVX3. Positions 78-492.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9UVX3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00007889 ; CADAFUAP00007889 ; CADAFUAG00007889 .
GeneIDi 3508953.
KEGGi afm:AFUA_4G08070.

Phylogenomic databases

eggNOGi COG5092.
HOGENOMi HOG000189123.
KOi K00671.
OMAi ATFRFKY.
OrthoDBi EOG78SQSW.

Family and domain databases

Gene3Di 3.40.630.30. 2 hits.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view ]
PANTHERi PTHR11377. PTHR11377. 1 hit.
Pfami PF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF015892. N-myristl_transf. 1 hit.
SUPFAMi SSF55729. SSF55729. 2 hits.
PROSITEi PS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "N-myristoyl transferase."
    Sakata K., Hashido K., Aoki Y., Arisawa M.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiNMT_ASPFU
AccessioniPrimary (citable) accession number: Q9UVX3
Secondary accession number(s): Q4WP53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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