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Q9UVX3 (NMT_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycylpeptide N-tetradecanoyltransferase
EC=2.3.1.97
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase
Short name=NMT
Peptide N-myristoyltransferase
Gene names
Name:nmt1
ORF Names:AFUA_4G08070
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus ›

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Catalytic activity

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the NMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processN-terminal protein myristoylation

Inferred from electronic annotation. Source: InterPro

replicative cell aging

Inferred from electronic annotation. Source: EnsemblFungi

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglycylpeptide N-tetradecanoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Glycylpeptide N-tetradecanoyltransferase
PRO_0000064235

Regions

Region82 – 854Myristoyl CoA-binding By similarity
Region212 – 24837Myristoyl CoA-binding By similarity

Sites

Active site4921Proton acceptor; via carboxylate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9UVX3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 921C0C5FF805F000

FASTA49256,255
        10         20         30         40         50         60 
MSDSKDRKGK APEGQSSEKK DGAVNITPQM AESLLENNPA LRNETAGMDK DKAAEAMRKM 

        70         80         90        100        110        120 
NIAELLTGLS VSGKNQKDMA SYKFWQTQPV PRFDETSTDT GGPIKIIDPE KVSKEPDALL 

       130        140        150        160        170        180 
EGFEWATLDL TNETELQELW DLLTYHYVED DNAMFRFRYS QSFLHWALMS PGWKKEWHVG 

       190        200        210        220        230        240 
VRATKSRKLV ASICGVPTEI NVRNQKLKVV EINFLCIHKK LRSKRLTPVL IKEITRRCYL 

       250        260        270        280        290        300 
NGIYQAIYTA GVVLPTPVSS CRYYHRPLDW LKLYEVGFSP LPAGSTKARQ ITKNHLPSTT 

       310        320        330        340        350        360 
STPGLRPMEP KDIDTVHDLL QRYLSRFALN QAFTREEVDH WLVHKPETVK EQVVWAYVVE 

       370        380        390        400        410        420 
DPETHKITDF FSFYNLESTV IQNPKHDNVR AAYLYYYATE TAFTNNMKAL KERLLMLMND 

       430        440        450        460        470        480 
ALILAKKAHF DVFNALTLHD NPLFLEQLKF GAGDGQLHFY LYNYRTAPVP GGVNEKNLPD 

       490 
EKRMGGVGIV ML

« Hide

References

« Hide 'large scale' references
[1]"N-myristoyl transferase."
Sakata K., Hashido K., Aoki Y., Arisawa M.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB035414 mRNA. Translation: BAA87865.1.
AAHF01000005 Genomic DNA. Translation: EAL89981.1.
RefSeqXP_752019.1. XM_746926.1.

3D structure databases

ProteinModelPortalQ9UVX3.
SMRQ9UVX3. Positions 78-492.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00007889; CADAFUAP00007889; CADAFUAG00007889.
GeneID3508953.
KEGGafm:AFUA_4G08070.

Phylogenomic databases

eggNOGCOG5092.
HOGENOMHOG000189123.
KOK00671.
OMAKNPAIPM.
OrthoDBEOG4V9XZZ.

Family and domain databases

Gene3D3.40.630.30. 2 hits.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERPTHR11377. PTHR11377. 1 hit.
PfamPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMSSF55729. Acyl_CoA_acyltransferase. 2 hits.
PROSITEPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNMT_ASPFU
AccessionPrimary (citable) accession number: Q9UVX3
Secondary accession number(s): Q4WP53
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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