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Q9UVX3

- NMT_ASPFU

UniProt

Q9UVX3 - NMT_ASPFU

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Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

nmt1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei492 – 4921Proton acceptor; via carboxylateBy similarity

GO - Molecular functioni

  1. glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. N-terminal protein myristoylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase (EC:2.3.1.97)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase
Short name:
NMT
Peptide N-myristoyltransferase
Gene namesi
Name:nmt1
ORF Names:AFUA_4G08070
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Glycylpeptide N-tetradecanoyltransferasePRO_0000064235Add
BLAST

Proteomic databases

PRIDEiQ9UVX3.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4CAVX-ray1.89A86-492[»]
4CAWX-ray2.50A86-492[»]
4CAXX-ray1.85A86-492[»]
ProteinModelPortaliQ9UVX3.
SMRiQ9UVX3. Positions 78-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 854Myristoyl CoA-bindingBy similarity
Regioni212 – 24837Myristoyl CoA-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

eggNOGiCOG5092.
HOGENOMiHOG000189123.
InParanoidiQ9UVX3.
KOiK00671.
OMAiATFRFKY.
OrthoDBiEOG78SQSW.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UVX3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDSKDRKGK APEGQSSEKK DGAVNITPQM AESLLENNPA LRNETAGMDK
60 70 80 90 100
DKAAEAMRKM NIAELLTGLS VSGKNQKDMA SYKFWQTQPV PRFDETSTDT
110 120 130 140 150
GGPIKIIDPE KVSKEPDALL EGFEWATLDL TNETELQELW DLLTYHYVED
160 170 180 190 200
DNAMFRFRYS QSFLHWALMS PGWKKEWHVG VRATKSRKLV ASICGVPTEI
210 220 230 240 250
NVRNQKLKVV EINFLCIHKK LRSKRLTPVL IKEITRRCYL NGIYQAIYTA
260 270 280 290 300
GVVLPTPVSS CRYYHRPLDW LKLYEVGFSP LPAGSTKARQ ITKNHLPSTT
310 320 330 340 350
STPGLRPMEP KDIDTVHDLL QRYLSRFALN QAFTREEVDH WLVHKPETVK
360 370 380 390 400
EQVVWAYVVE DPETHKITDF FSFYNLESTV IQNPKHDNVR AAYLYYYATE
410 420 430 440 450
TAFTNNMKAL KERLLMLMND ALILAKKAHF DVFNALTLHD NPLFLEQLKF
460 470 480 490
GAGDGQLHFY LYNYRTAPVP GGVNEKNLPD EKRMGGVGIV ML
Length:492
Mass (Da):56,255
Last modified:May 1, 2000 - v1
Checksum:i921C0C5FF805F000
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB035414 mRNA. Translation: BAA87865.1.
AAHF01000005 Genomic DNA. Translation: EAL89981.1.
RefSeqiXP_752019.1. XM_746926.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00007889; CADAFUAP00007889; CADAFUAG00007889.
GeneIDi3508953.
KEGGiafm:AFUA_4G08070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB035414 mRNA. Translation: BAA87865.1 .
AAHF01000005 Genomic DNA. Translation: EAL89981.1 .
RefSeqi XP_752019.1. XM_746926.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4CAV X-ray 1.89 A 86-492 [» ]
4CAW X-ray 2.50 A 86-492 [» ]
4CAX X-ray 1.85 A 86-492 [» ]
ProteinModelPortali Q9UVX3.
SMRi Q9UVX3. Positions 78-492.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9UVX3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00007889 ; CADAFUAP00007889 ; CADAFUAG00007889 .
GeneIDi 3508953.
KEGGi afm:AFUA_4G08070.

Phylogenomic databases

eggNOGi COG5092.
HOGENOMi HOG000189123.
InParanoidi Q9UVX3.
KOi K00671.
OMAi ATFRFKY.
OrthoDBi EOG78SQSW.

Family and domain databases

Gene3Di 3.40.630.30. 2 hits.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view ]
PANTHERi PTHR11377. PTHR11377. 1 hit.
Pfami PF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF015892. N-myristl_transf. 1 hit.
SUPFAMi SSF55729. SSF55729. 2 hits.
PROSITEi PS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "N-myristoyl transferase."
    Sakata K., Hashido K., Aoki Y., Arisawa M.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiNMT_ASPFU
AccessioniPrimary (citable) accession number: Q9UVX3
Secondary accession number(s): Q4WP53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3