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Q9UVX3

- NMT_ASPFU

UniProt

Q9UVX3 - NMT_ASPFU

Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

nmt1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

    Catalytic activityi

    Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei492 – 4921Proton acceptor; via carboxylateBy similarity

    GO - Molecular functioni

    1. glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. N-terminal protein myristoylation Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferase (EC:2.3.1.97)
    Alternative name(s):
    Myristoyl-CoA:protein N-myristoyltransferase
    Short name:
    NMT
    Peptide N-myristoyltransferase
    Gene namesi
    Name:nmt1
    ORF Names:AFUA_4G08070
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Glycylpeptide N-tetradecanoyltransferasePRO_0000064235Add
    BLAST

    Proteomic databases

    PRIDEiQ9UVX3.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UVX3.
    SMRiQ9UVX3. Positions 78-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni82 – 854Myristoyl CoA-bindingBy similarity
    Regioni212 – 24837Myristoyl CoA-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NMT family.Curated

    Phylogenomic databases

    eggNOGiCOG5092.
    HOGENOMiHOG000189123.
    KOiK00671.
    OMAiATFRFKY.
    OrthoDBiEOG78SQSW.

    Family and domain databases

    Gene3Di3.40.630.30. 2 hits.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000903. MyristoylCoA_TrFase.
    IPR022677. MyristoylCoA_TrFase_C.
    IPR022678. MyristoylCoA_TrFase_CS.
    IPR022676. MyristoylCoA_TrFase_N.
    [Graphical view]
    PANTHERiPTHR11377. PTHR11377. 1 hit.
    PfamiPF01233. NMT. 1 hit.
    PF02799. NMT_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
    SUPFAMiSSF55729. SSF55729. 2 hits.
    PROSITEiPS00975. NMT_1. 1 hit.
    PS00976. NMT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UVX3-1 [UniParc]FASTAAdd to Basket

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    MSDSKDRKGK APEGQSSEKK DGAVNITPQM AESLLENNPA LRNETAGMDK    50
    DKAAEAMRKM NIAELLTGLS VSGKNQKDMA SYKFWQTQPV PRFDETSTDT 100
    GGPIKIIDPE KVSKEPDALL EGFEWATLDL TNETELQELW DLLTYHYVED 150
    DNAMFRFRYS QSFLHWALMS PGWKKEWHVG VRATKSRKLV ASICGVPTEI 200
    NVRNQKLKVV EINFLCIHKK LRSKRLTPVL IKEITRRCYL NGIYQAIYTA 250
    GVVLPTPVSS CRYYHRPLDW LKLYEVGFSP LPAGSTKARQ ITKNHLPSTT 300
    STPGLRPMEP KDIDTVHDLL QRYLSRFALN QAFTREEVDH WLVHKPETVK 350
    EQVVWAYVVE DPETHKITDF FSFYNLESTV IQNPKHDNVR AAYLYYYATE 400
    TAFTNNMKAL KERLLMLMND ALILAKKAHF DVFNALTLHD NPLFLEQLKF 450
    GAGDGQLHFY LYNYRTAPVP GGVNEKNLPD EKRMGGVGIV ML 492
    Length:492
    Mass (Da):56,255
    Last modified:May 1, 2000 - v1
    Checksum:i921C0C5FF805F000
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035414 mRNA. Translation: BAA87865.1.
    AAHF01000005 Genomic DNA. Translation: EAL89981.1.
    RefSeqiXP_752019.1. XM_746926.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00007889; CADAFUAP00007889; CADAFUAG00007889.
    GeneIDi3508953.
    KEGGiafm:AFUA_4G08070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035414 mRNA. Translation: BAA87865.1 .
    AAHF01000005 Genomic DNA. Translation: EAL89981.1 .
    RefSeqi XP_752019.1. XM_746926.1.

    3D structure databases

    ProteinModelPortali Q9UVX3.
    SMRi Q9UVX3. Positions 78-492.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9UVX3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00007889 ; CADAFUAP00007889 ; CADAFUAG00007889 .
    GeneIDi 3508953.
    KEGGi afm:AFUA_4G08070.

    Phylogenomic databases

    eggNOGi COG5092.
    HOGENOMi HOG000189123.
    KOi K00671.
    OMAi ATFRFKY.
    OrthoDBi EOG78SQSW.

    Family and domain databases

    Gene3Di 3.40.630.30. 2 hits.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000903. MyristoylCoA_TrFase.
    IPR022677. MyristoylCoA_TrFase_C.
    IPR022678. MyristoylCoA_TrFase_CS.
    IPR022676. MyristoylCoA_TrFase_N.
    [Graphical view ]
    PANTHERi PTHR11377. PTHR11377. 1 hit.
    Pfami PF01233. NMT. 1 hit.
    PF02799. NMT_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015892. N-myristl_transf. 1 hit.
    SUPFAMi SSF55729. SSF55729. 2 hits.
    PROSITEi PS00975. NMT_1. 1 hit.
    PS00976. NMT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "N-myristoyl transferase."
      Sakata K., Hashido K., Aoki Y., Arisawa M.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiNMT_ASPFU
    AccessioniPrimary (citable) accession number: Q9UVX3
    Secondary accession number(s): Q4WP53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3