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Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

nmt1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei492Proton acceptor; via carboxylateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase (EC:2.3.1.97)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase
Short name:
NMT
Peptide N-myristoyltransferase
Gene namesi
Name:nmt1
ORF Names:AFUA_4G08070
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:Afu4g08070.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642351 – 492Glycylpeptide N-tetradecanoyltransferaseAdd BLAST492

Proteomic databases

PRIDEiQ9UVX3.

Interactioni

Subunit structurei

Monomer.By similarity

Chemistry databases

BindingDBiQ9UVX3.

Structurei

Secondary structure

1492
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi102 – 104Combined sources3
Helixi109 – 111Combined sources3
Beta strandi123 – 127Combined sources5
Helixi133 – 146Combined sources14
Beta strandi147 – 150Combined sources4
Beta strandi155 – 158Combined sources4
Helixi161 – 168Combined sources8
Helixi175 – 177Combined sources3
Beta strandi178 – 183Combined sources6
Turni184 – 186Combined sources3
Beta strandi189 – 202Combined sources14
Beta strandi205 – 217Combined sources13
Helixi219 – 221Combined sources3
Beta strandi223 – 225Combined sources3
Helixi226 – 240Combined sources15
Beta strandi246 – 252Combined sources7
Beta strandi258 – 269Combined sources12
Helixi270 – 275Combined sources6
Helixi287 – 293Combined sources7
Beta strandi305 – 307Combined sources3
Helixi310 – 312Combined sources3
Helixi313 – 324Combined sources12
Beta strandi327 – 331Combined sources5
Helixi335 – 342Combined sources8
Turni346 – 348Combined sources3
Beta strandi354 – 360Combined sources7
Turni362 – 364Combined sources3
Beta strandi366 – 382Combined sources17
Beta strandi387 – 399Combined sources13
Helixi400 – 404Combined sources5
Helixi407 – 427Combined sources21
Beta strandi431 – 437Combined sources7
Helixi441 – 443Combined sources3
Turni444 – 449Combined sources6
Beta strandi451 – 465Combined sources15
Beta strandi477 – 479Combined sources3
Helixi481 – 483Combined sources3
Beta strandi485 – 488Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CAVX-ray1.89A86-492[»]
4CAWX-ray2.50A86-492[»]
4CAXX-ray1.85A86-492[»]
4QBJX-ray2.10A101-492[»]
4UWIX-ray1.80A86-492[»]
4UWJX-ray1.70A86-492[»]
ProteinModelPortaliQ9UVX3.
SMRiQ9UVX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 85Myristoyl CoA-bindingBy similarity4
Regioni212 – 248Myristoyl CoA-bindingBy similarityAdd BLAST37

Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

HOGENOMiHOG000189123.
InParanoidiQ9UVX3.
KOiK00671.
OMAiGFEWVTM.
OrthoDBiEOG092C3LZ4.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UVX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSKDRKGK APEGQSSEKK DGAVNITPQM AESLLENNPA LRNETAGMDK
60 70 80 90 100
DKAAEAMRKM NIAELLTGLS VSGKNQKDMA SYKFWQTQPV PRFDETSTDT
110 120 130 140 150
GGPIKIIDPE KVSKEPDALL EGFEWATLDL TNETELQELW DLLTYHYVED
160 170 180 190 200
DNAMFRFRYS QSFLHWALMS PGWKKEWHVG VRATKSRKLV ASICGVPTEI
210 220 230 240 250
NVRNQKLKVV EINFLCIHKK LRSKRLTPVL IKEITRRCYL NGIYQAIYTA
260 270 280 290 300
GVVLPTPVSS CRYYHRPLDW LKLYEVGFSP LPAGSTKARQ ITKNHLPSTT
310 320 330 340 350
STPGLRPMEP KDIDTVHDLL QRYLSRFALN QAFTREEVDH WLVHKPETVK
360 370 380 390 400
EQVVWAYVVE DPETHKITDF FSFYNLESTV IQNPKHDNVR AAYLYYYATE
410 420 430 440 450
TAFTNNMKAL KERLLMLMND ALILAKKAHF DVFNALTLHD NPLFLEQLKF
460 470 480 490
GAGDGQLHFY LYNYRTAPVP GGVNEKNLPD EKRMGGVGIV ML
Length:492
Mass (Da):56,255
Last modified:May 1, 2000 - v1
Checksum:i921C0C5FF805F000
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035414 mRNA. Translation: BAA87865.1.
AAHF01000005 Genomic DNA. Translation: EAL89981.1.
RefSeqiXP_752019.1. XM_746926.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00007889; CADAFUAP00007889; CADAFUAG00007889.
GeneIDi3508953.
KEGGiafm:AFUA_4G08070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035414 mRNA. Translation: BAA87865.1.
AAHF01000005 Genomic DNA. Translation: EAL89981.1.
RefSeqiXP_752019.1. XM_746926.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CAVX-ray1.89A86-492[»]
4CAWX-ray2.50A86-492[»]
4CAXX-ray1.85A86-492[»]
4QBJX-ray2.10A101-492[»]
4UWIX-ray1.80A86-492[»]
4UWJX-ray1.70A86-492[»]
ProteinModelPortaliQ9UVX3.
SMRiQ9UVX3.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiQ9UVX3.

Proteomic databases

PRIDEiQ9UVX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00007889; CADAFUAP00007889; CADAFUAG00007889.
GeneIDi3508953.
KEGGiafm:AFUA_4G08070.

Organism-specific databases

EuPathDBiFungiDB:Afu4g08070.

Phylogenomic databases

HOGENOMiHOG000189123.
InParanoidiQ9UVX3.
KOiK00671.
OMAiGFEWVTM.
OrthoDBiEOG092C3LZ4.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMT_ASPFU
AccessioniPrimary (citable) accession number: Q9UVX3
Secondary accession number(s): Q4WP53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.