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Protein

Lysophospholipase 3

Gene

PLB3

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 3 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 3
Gene namesi
Name:PLB3
Synonyms:PLB1
ORF Names:Ca41C10.12
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002463220 – 754Lysophospholipase 3Add BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi354N-linked (GlcNAc...)Sequence analysis1
Glycosylationi391N-linked (GlcNAc...)Sequence analysis1
Glycosylationi423N-linked (GlcNAc...)Sequence analysis1
Glycosylationi470N-linked (GlcNAc...)Sequence analysis1
Glycosylationi510N-linked (GlcNAc...)Sequence analysis1
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Glycosylationi560N-linked (GlcNAc...)Sequence analysis1
Glycosylationi577N-linked (GlcNAc...)Sequence analysis1
Glycosylationi597N-linked (GlcNAc...)Sequence analysis1
Glycosylationi625N-linked (GlcNAc...)Sequence analysis1
Glycosylationi631N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9UVX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 670PLA2cPROSITE-ProRule annotationAdd BLAST557

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UVX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVNLKLIIG SILISQAQAI WPFDSSGSSS SSDSSPSETG SSGGTFPFDL
60 70 80 90 100
FGSGSSLTQS SSAQASSTKS TSDSASSTDS SLFSSSNSGS SWYQTFLDGD
110 120 130 140 150
SGDQKTDYAP FNLTCPSKKT FIRTASELSQ QEKDYIHKRQ ETTNKNLIDF
160 170 180 190 200
LSKRANLSDF DAKSFINDNA PNHNITIGLS FSGGGYRAML AGAGQILGLD
210 220 230 240 250
GRYEDANKHG LGGLLDSSTY VVGLSGGNWL VGSLALNDWL SVGDIVNGKS
260 270 280 290 300
TIWQLQDSIL NPSGMRIDKT IAYYYGLAQA VQAKEDAGFQ TSVTDTWGRA
310 320 330 340 350
LSYQFFEEDD SGTGGANITW SSIRNLSSFQ DHSMPYPIVV ANGRTPGTYI
360 370 380 390 400
INENSTIFEI SPYELGSWDP SLKSFSNIQY LGSSVNNGNP NNTDICVNNF
410 420 430 440 450
DNAGFIMGTS SSLFNQILLQ LDNYSINSII KMILEKVLTD VSDEEYDIAV
460 470 480 490 500
YEPNPFFGAD SAGIKSITTN DTLYLCDGGE DLQNVPFYPL IQNKRGVDVI
510 520 530 540 550
FAFDNSADTN SSWPNGTSIQ ETYKRQFSKQ GKGTPFPFAP DYKTFLDKNM
560 570 580 590 600
GDKPVFFGCN SSDLEDLVAW HENDKINVTD VPLVVYTSNT RMSYNSNFST
610 620 630 640 650
FKLSYSDQEK FGAIRNGFET VTRNNLTDDE NWSTCVGCAI IRRQQERLGE
660 670 680 690 700
EQSDECKKCF QEYCWTGGFK DAASVSSVSG ISGLAAKTHT SGGTSSTTQQ
710 720 730 740 750
TSTTTGSSAN GGSSSTGSSS SSKKKNGGDL VNGGVPSSIF LVFNSLLGLI

IAYL
Length:754
Mass (Da):81,412
Last modified:October 10, 2003 - v2
Checksum:i8291D959B005B554
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377N → D in AAF08980 (Ref. 1) Curated1
Sequence conflicti494K → E in AAF08980 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038128 Genomic DNA. Translation: AAF08980.1.
AL033501 Genomic DNA. Translation: CAA21996.1.
PIRiT18238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038128 Genomic DNA. Translation: AAF08980.1.
AL033501 Genomic DNA. Translation: CAA21996.1.
PIRiT18238.

3D structure databases

ProteinModelPortaliQ9UVX1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLB3_CANAX
AccessioniPrimary (citable) accession number: Q9UVX1
Secondary accession number(s): O94046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 11, 2015
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.