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Q9UVX1

- PLB3_CANAX

UniProt

Q9UVX1 - PLB3_CANAX

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Protein
Lysophospholipase 3
Gene
PLB3, PLB1, Ca41C10.12
Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 3 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 3
Gene namesi
Name:PLB3
Synonyms:PLB1
ORF Names:Ca41C10.12
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 754735Lysophospholipase 3
PRO_0000024632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi354 – 3541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi423 – 4231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi470 – 4701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi510 – 5101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi560 – 5601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi577 – 5771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi597 – 5971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi625 – 6251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi631 – 6311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ9UVX1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 670557PLA2c
Add
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.
Contains 1 PLA2c domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG271081.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UVX1-1 [UniParc]FASTAAdd to Basket

« Hide

MKVNLKLIIG SILISQAQAI WPFDSSGSSS SSDSSPSETG SSGGTFPFDL    50
FGSGSSLTQS SSAQASSTKS TSDSASSTDS SLFSSSNSGS SWYQTFLDGD 100
SGDQKTDYAP FNLTCPSKKT FIRTASELSQ QEKDYIHKRQ ETTNKNLIDF 150
LSKRANLSDF DAKSFINDNA PNHNITIGLS FSGGGYRAML AGAGQILGLD 200
GRYEDANKHG LGGLLDSSTY VVGLSGGNWL VGSLALNDWL SVGDIVNGKS 250
TIWQLQDSIL NPSGMRIDKT IAYYYGLAQA VQAKEDAGFQ TSVTDTWGRA 300
LSYQFFEEDD SGTGGANITW SSIRNLSSFQ DHSMPYPIVV ANGRTPGTYI 350
INENSTIFEI SPYELGSWDP SLKSFSNIQY LGSSVNNGNP NNTDICVNNF 400
DNAGFIMGTS SSLFNQILLQ LDNYSINSII KMILEKVLTD VSDEEYDIAV 450
YEPNPFFGAD SAGIKSITTN DTLYLCDGGE DLQNVPFYPL IQNKRGVDVI 500
FAFDNSADTN SSWPNGTSIQ ETYKRQFSKQ GKGTPFPFAP DYKTFLDKNM 550
GDKPVFFGCN SSDLEDLVAW HENDKINVTD VPLVVYTSNT RMSYNSNFST 600
FKLSYSDQEK FGAIRNGFET VTRNNLTDDE NWSTCVGCAI IRRQQERLGE 650
EQSDECKKCF QEYCWTGGFK DAASVSSVSG ISGLAAKTHT SGGTSSTTQQ 700
TSTTTGSSAN GGSSSTGSSS SSKKKNGGDL VNGGVPSSIF LVFNSLLGLI 750
IAYL 754
Length:754
Mass (Da):81,412
Last modified:October 10, 2003 - v2
Checksum:i8291D959B005B554
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti377 – 3771N → D in AAF08980. 1 Publication
Sequence conflicti494 – 4941K → E in AAF08980. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038128 Genomic DNA. Translation: AAF08980.1.
AL033501 Genomic DNA. Translation: CAA21996.1.
PIRiT18238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038128 Genomic DNA. Translation: AAF08980.1 .
AL033501 Genomic DNA. Translation: CAA21996.1 .
PIRi T18238.

3D structure databases

ProteinModelPortali Q9UVX1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG271081.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Putative phospholipase B precursor of Candida albicans."
    Theiss S., Koehler G.A.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SS.
  2. "Candida albicans strain 1161 genome pilot sequencing project."
    Taylor K., Harris D., Barrell B.G., Rajandream M.A.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1161.

Entry informationi

Entry nameiPLB3_CANAX
AccessioniPrimary (citable) accession number: Q9UVX1
Secondary accession number(s): O94046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: October 16, 2013
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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