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Q9UVX1 (PLB3_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase 3

EC=3.1.1.5
Alternative name(s):
Phospholipase B 3
Gene names
Name:PLB3
Synonyms:PLB1
ORF Names:Ca41C10.12
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length754 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the lysophospholipase family.

Contains 1 PLA2c domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processphospholipid catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 754735Lysophospholipase 3
PRO_0000024632

Regions

Domain114 – 670557PLA2c

Amino acid modifications

Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation1741N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation3251N-linked (GlcNAc...) Potential
Glycosylation3541N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4231N-linked (GlcNAc...) Potential
Glycosylation4701N-linked (GlcNAc...) Potential
Glycosylation5101N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Glycosylation5601N-linked (GlcNAc...) Potential
Glycosylation5771N-linked (GlcNAc...) Potential
Glycosylation5971N-linked (GlcNAc...) Potential
Glycosylation6251N-linked (GlcNAc...) Potential
Glycosylation6311N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3771N → D in AAF08980. Ref.1
Sequence conflict4941K → E in AAF08980. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UVX1 [UniParc].

Last modified October 10, 2003. Version 2.
Checksum: 8291D959B005B554

FASTA75481,412
        10         20         30         40         50         60 
MKVNLKLIIG SILISQAQAI WPFDSSGSSS SSDSSPSETG SSGGTFPFDL FGSGSSLTQS 

        70         80         90        100        110        120 
SSAQASSTKS TSDSASSTDS SLFSSSNSGS SWYQTFLDGD SGDQKTDYAP FNLTCPSKKT 

       130        140        150        160        170        180 
FIRTASELSQ QEKDYIHKRQ ETTNKNLIDF LSKRANLSDF DAKSFINDNA PNHNITIGLS 

       190        200        210        220        230        240 
FSGGGYRAML AGAGQILGLD GRYEDANKHG LGGLLDSSTY VVGLSGGNWL VGSLALNDWL 

       250        260        270        280        290        300 
SVGDIVNGKS TIWQLQDSIL NPSGMRIDKT IAYYYGLAQA VQAKEDAGFQ TSVTDTWGRA 

       310        320        330        340        350        360 
LSYQFFEEDD SGTGGANITW SSIRNLSSFQ DHSMPYPIVV ANGRTPGTYI INENSTIFEI 

       370        380        390        400        410        420 
SPYELGSWDP SLKSFSNIQY LGSSVNNGNP NNTDICVNNF DNAGFIMGTS SSLFNQILLQ 

       430        440        450        460        470        480 
LDNYSINSII KMILEKVLTD VSDEEYDIAV YEPNPFFGAD SAGIKSITTN DTLYLCDGGE 

       490        500        510        520        530        540 
DLQNVPFYPL IQNKRGVDVI FAFDNSADTN SSWPNGTSIQ ETYKRQFSKQ GKGTPFPFAP 

       550        560        570        580        590        600 
DYKTFLDKNM GDKPVFFGCN SSDLEDLVAW HENDKINVTD VPLVVYTSNT RMSYNSNFST 

       610        620        630        640        650        660 
FKLSYSDQEK FGAIRNGFET VTRNNLTDDE NWSTCVGCAI IRRQQERLGE EQSDECKKCF 

       670        680        690        700        710        720 
QEYCWTGGFK DAASVSSVSG ISGLAAKTHT SGGTSSTTQQ TSTTTGSSAN GGSSSTGSSS 

       730        740        750 
SSKKKNGGDL VNGGVPSSIF LVFNSLLGLI IAYL 

« Hide

References

« Hide 'large scale' references
[1]"Putative phospholipase B precursor of Candida albicans."
Theiss S., Koehler G.A.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SS.
[2]"Candida albicans strain 1161 genome pilot sequencing project."
Taylor K., Harris D., Barrell B.G., Rajandream M.A.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1161.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF038128 Genomic DNA. Translation: AAF08980.1.
AL033501 Genomic DNA. Translation: CAA21996.1.
PIRT18238.

3D structure databases

ProteinModelPortalQ9UVX1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG271081.

Family and domain databases

InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 1 hit.
PROSITEPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLB3_CANAX
AccessionPrimary (citable) accession number: Q9UVX1
Secondary accession number(s): O94046
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: October 16, 2013
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families