Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UVX1

- PLB3_CANAX

UniProt

Q9UVX1 - PLB3_CANAX

Protein

Lysophospholipase 3

Gene

PLB3

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phospholipid catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase 3 (EC:3.1.1.5)
    Alternative name(s):
    Phospholipase B 3
    Gene namesi
    Name:PLB3
    Synonyms:PLB1
    ORF Names:Ca41C10.12
    OrganismiCandida albicans (Yeast)
    Taxonomic identifieri5476 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 754735Lysophospholipase 3PRO_0000024632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi510 – 5101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi560 – 5601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi577 – 5771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi597 – 5971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi625 – 6251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi631 – 6311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UVX1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini114 – 670557PLA2cPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lysophospholipase family.Curated
    Contains 1 PLA2c domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG271081.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view]
    PfamiPF01735. PLA2_B. 1 hit.
    [Graphical view]
    SMARTiSM00022. PLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.
    PROSITEiPS51210. PLA2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UVX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVNLKLIIG SILISQAQAI WPFDSSGSSS SSDSSPSETG SSGGTFPFDL    50
    FGSGSSLTQS SSAQASSTKS TSDSASSTDS SLFSSSNSGS SWYQTFLDGD 100
    SGDQKTDYAP FNLTCPSKKT FIRTASELSQ QEKDYIHKRQ ETTNKNLIDF 150
    LSKRANLSDF DAKSFINDNA PNHNITIGLS FSGGGYRAML AGAGQILGLD 200
    GRYEDANKHG LGGLLDSSTY VVGLSGGNWL VGSLALNDWL SVGDIVNGKS 250
    TIWQLQDSIL NPSGMRIDKT IAYYYGLAQA VQAKEDAGFQ TSVTDTWGRA 300
    LSYQFFEEDD SGTGGANITW SSIRNLSSFQ DHSMPYPIVV ANGRTPGTYI 350
    INENSTIFEI SPYELGSWDP SLKSFSNIQY LGSSVNNGNP NNTDICVNNF 400
    DNAGFIMGTS SSLFNQILLQ LDNYSINSII KMILEKVLTD VSDEEYDIAV 450
    YEPNPFFGAD SAGIKSITTN DTLYLCDGGE DLQNVPFYPL IQNKRGVDVI 500
    FAFDNSADTN SSWPNGTSIQ ETYKRQFSKQ GKGTPFPFAP DYKTFLDKNM 550
    GDKPVFFGCN SSDLEDLVAW HENDKINVTD VPLVVYTSNT RMSYNSNFST 600
    FKLSYSDQEK FGAIRNGFET VTRNNLTDDE NWSTCVGCAI IRRQQERLGE 650
    EQSDECKKCF QEYCWTGGFK DAASVSSVSG ISGLAAKTHT SGGTSSTTQQ 700
    TSTTTGSSAN GGSSSTGSSS SSKKKNGGDL VNGGVPSSIF LVFNSLLGLI 750
    IAYL 754
    Length:754
    Mass (Da):81,412
    Last modified:October 10, 2003 - v2
    Checksum:i8291D959B005B554
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti377 – 3771N → D in AAF08980. 1 PublicationCurated
    Sequence conflicti494 – 4941K → E in AAF08980. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038128 Genomic DNA. Translation: AAF08980.1.
    AL033501 Genomic DNA. Translation: CAA21996.1.
    PIRiT18238.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038128 Genomic DNA. Translation: AAF08980.1 .
    AL033501 Genomic DNA. Translation: CAA21996.1 .
    PIRi T18238.

    3D structure databases

    ProteinModelPortali Q9UVX1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG271081.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view ]
    Pfami PF01735. PLA2_B. 1 hit.
    [Graphical view ]
    SMARTi SM00022. PLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    PROSITEi PS51210. PLA2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Putative phospholipase B precursor of Candida albicans."
      Theiss S., Koehler G.A.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SS.
    2. "Candida albicans strain 1161 genome pilot sequencing project."
      Taylor K., Harris D., Barrell B.G., Rajandream M.A.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1161.

    Entry informationi

    Entry nameiPLB3_CANAX
    AccessioniPrimary (citable) accession number: Q9UVX1
    Secondary accession number(s): O94046
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 50 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3