true2010-04-202024-01-2493CBHB_ASPNGTwo cellobiohydrolase-encoding genes from Aspergillus niger require D-xylose and the xylanolytic transcriptional activator XlnR for their expression.Gielkens M.M.Dekkers E.Visser J.de Graaff L.H.doi:10.1128/aem.65.10.4340-4345.19991999Appl. Environ. Microbiol.654340-4345NUCLEOTIDE SEQUENCE [GENOMIC DNA]INDUCTIONATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400 / FGSC 732Induction, production, repression, and de-repression of exoglucanase synthesis in Aspergillus niger.Hanif A.Yasmeen A.Rajoka M.I.doi:10.1016/j.biortech.2003.12.0132004Bioresour. Technol.94311-319FUNCTIONINDUCTIONCarbohydrate-Binding Module Family 1Glycoside Hydrolase Family 72 sites, No reported glycansEukaryota518GH7_CBH_EGGlycoside hydrolase, family 7, domainCBD_sfCellulose-bd_dom_funConA-like_dom_sfGlyco_hydro_7Glyco_hydro_7_sf1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE BCBM_1Glyco_hydro_7GLHYDRLASE7fCBDCellulose-binding domainConcanavalin A-like lectins/glucanasesCBM1_1CBM1_21,4-beta-D-glucan cellobiohydrolase B3.2.1.91Beta-glucancellobiohydrolase BExocellobiohydrolase BExoglucanase BcbhBThe biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.Expression is under the control of the xylanolytic transcriptional activator xlnR.Belongs to the glycosyl hydrolase 7 (cellulase C) family.1211,4-beta-D-glucan cellobiohydrolase B5398222536CBM1500Catalytic458Ser/Thr-rich linker459Disordered464499Nucleophile233Proton donor238N-linked (GlcNAc...) asparagine351N-linked (GlcNAc...) asparagine4145085255195352000-05-011true56219ab53db8a6e58167612f72bc83aa2eb16MSSFQIYRAALLLSILATANAQQVGTYTTETHPSLTWQTCTSDGSCTTNDGEVVIDANWRWVHSTSSATNCYTGNEWDTSICTDDVTCAANCALDGATYEATYGVTTSGSELRLNFVTQGSSKNIGSRLYLMSDDSNYELFKLLGQEFTFDVDVSNLPCGLNGALYFVAMDADGGTSEYSGNKAGAKYGTGYCDSQCPRDLKFINGEANCDGWEPSSNNVNTGVGDHGSCCAEMDVWEANSISNAFTAHPCDSVSQTMCDGDSCGGTYSASGDRYSGTCDPDGCDYNPYRLGNTDFYGPGLTVDTNSPFTVVTQFITDDGTSSGTLTEIKRLYVQNGEVIANGASTYSSVNGSSITSAFCESEKTLFGDENVFDKHGGLEGMGEAMAKGMVLVLSLWDDYAADMLWLDSDYPVNSSASTPGVARGTCSTDSGVPATVEAESPNAYVTYSNIKFGPIGSTYSSGSSSGSGSSSSSSSTTTKATSTTLKTTSTTSSGSSSTSAAQAYGQCGGQGWTGPTTCVSGYTCTYENAYYSQCLtruetruetruetruetruetrue