Reviewed,
UniProtKB/Swiss-Prot Q9UVF4 (GPD1_YARLI)
Last modified
November 4, 2008.
Version 53.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glycerol-3-phosphate dehydrogenase [NAD+] 1 EC=1.1.1.8 | ||||
| Gene names |
| ||||
| Organism | Yarrowia lipolytica (Candida lipolytica) [Complete proteome] | ||||
| Taxonomic identifier | 4952 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia |
Protein attributes
| Sequence length | 398 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. |
| Subcellular location | CytoplasmProbable. |
| Sequence similarities | Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. |
| Caution | It is uncertain whether Met-1 or Met-14 is the initiator. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 398 | 398 | Glycerol-3-phosphate dehydrogenase [NAD+] 1 | PRO_0000138098 | |||||
Regions | |||||||||
| Nucleotide binding | 50 – 55 | 6 | NAD By similarity | ||||||
| Region | 318 – 319 | 2 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 253 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 138 | 1 | NAD By similarity | ||||||
| Binding site | 161 | 1 | NAD; via amide nitrogen By similarity | ||||||
| Binding site | 161 | 1 | Substrate By similarity | ||||||
| Binding site | 194 | 1 | NAD; via amide nitrogen By similarity | ||||||
| Binding site | 318 | 1 | NAD By similarity | ||||||
| Binding site | 350 | 1 | NAD By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Glycerol 3 phosphate dehydrogenase from Yarrowia lipolityca." Nicaud J.-M., le Dall M.-T., Choquer M. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 20460 / W29 / CBS 7504 / IFP29. |
| [2] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L.Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150. |
Cross-references
Sequence databases | |
|---|---|
| AJ250328 Genomic DNA. Translation: CAB58452.1. CR382128 Genomic DNA. Translation: CAG82664.1. | |
| RefSeq | XP_500444.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EVY based on UniProtKB P90551. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2906777. |
| KEGG | yli:YALI0B02948g. |
Phylogenomic databases | |
| HOGENOM | Q9UVF4. |
Family and domain databases | |
| InterPro | IPR013328. DHase_multihelical. IPR016040. NAD(P)-bd. IPR017751. NAD-dep_Gly3P_DH_euk. IPR006168. NAD-dep_Gly3P_DHase. IPR011128. NAD-dep_Gly3P_DHase_N. IPR006109. NAD_Gly3P_DHase_C. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| PANTHER | PTHR11728. NAD_Gly3P_DH. 1 hit. |
| Pfam | PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000114. Glycerol-3-P_dh. 1 hit. |
| PRINTS | PR00077. GPDHDRGNASE. |
| ProDom | PD001278. NAD_Gly3P_C. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00957. NAD_G3PDH. 1 hit. [Graphical view] |
| BLOCKS | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | GPD1_YARLI | ||||||||
| Accession | Primary (citable) accession number: Q9UVF4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

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