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Q9UVF4 (GPD1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1

EC=1.1.1.8
Gene names
Name:GPD1
Ordered Locus Names:YALI0B02948g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398Glycerol-3-phosphate dehydrogenase [NAD(+)] 1
PRO_0000138098

Regions

Nucleotide binding50 – 556NAD By similarity
Region318 – 3192Substrate binding By similarity

Sites

Active site2531Proton acceptor By similarity
Binding site1381NAD By similarity
Binding site1611NAD; via amide nitrogen By similarity
Binding site1611Substrate By similarity
Binding site1941NAD; via amide nitrogen By similarity
Binding site3181NAD By similarity
Binding site3501NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9UVF4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: C576DA65AB076E1E

FASTA39843,459
        10         20         30         40         50         60 
MSALLRSSLR FKHMSAVNRL TQQLRLLTAS APLSAANTAG KAPFKVAVVG SGNWGTTVAK 

        70         80         90        100        110        120 
IVAENCTAHP ELFEPEVRVW VREEKVNGKN LTDIFNAEHE NVRYLPKIKL PHNLIAEPDL 

       130        140        150        160        170        180 
LKAVEGANII VFNLPHQFLA GVCKQLKGHV NPKARAISCL KGLDVTPQGV YLLSDVIENE 

       190        200        210        220        230        240 
TGLHCGVLSG ANLATEIALE KYSETTVAYN RPKDFFGEGD VTNDVLKALF HRPYFHVRCV 

       250        260        270        280        290        300 
QDVAGVSIGG ALKNVVALCA GFVEGKNWGD NAKAAIMRRG MLEMINFSKR FFPETDINTL 

       310        320        330        340        350        360 
TVESAGVADL ITSCAGGRNF KVGRAFGKES GSGKTIQDVE KELLNGQSAQ GVITCNEVHE 

       370        380        390 
LLKNKNMQKD FPLFESTWGI IHGELKIDDL PEILYHAN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ250328 Genomic DNA. Translation: CAB58452.1.
CR382128 Genomic DNA. Translation: CAG82664.1.
RefSeqXP_500444.1. XM_500444.1.

3D structure databases

ProteinModelPortalQ9UVF4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q9UVF4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG82664; CAG82664; YALI0_B02948g.
GeneID2906777.
KEGGyli:YALI0B02948g.

Phylogenomic databases

eggNOGCOG0240.
HOGENOMHOG000246855.
KOK00006.
OMAPVGEFIH.
OrthoDBEOG7V76H7.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR03376. glycerol3P_DH. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPD1_YARLI
AccessionPrimary (citable) accession number: Q9UVF4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families