Q9UVF4 (GPD1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1
EC=1.1.1.8

Gene names

Name:	GPD1
Ordered Locus Names:	YALI0B02948g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia › Yarrowia lipolytica

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
Caution	It is uncertain whether Met-1 or Met-14 is the initiator.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate dehydrogenase [NAD+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Glycerol-3-phosphate dehydrogenase [NAD(+)] 1		PRO_0000138098
Regions
	Nucleotide binding	50 – 55	6	NAD By similarity
	Region	318 – 319	2	Substrate binding By similarity
Sites
	Active site	253	1	Proton acceptor By similarity
	Binding site	138	1	NAD By similarity
	Binding site	161	1	NAD; via amide nitrogen By similarity
	Binding site	161	1	Substrate By similarity
	Binding site	194	1	NAD; via amide nitrogen By similarity
	Binding site	318	1	NAD By similarity
	Binding site	350	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UVF4 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C576DA65AB076E1E	FASTA	398	43,459
	10 20 30 40 50 60 MSALLRSSLR FKHMSAVNRL TQQLRLLTAS APLSAANTAG KAPFKVAVVG SGNWGTTVAK 70 80 90 100 110 120 IVAENCTAHP ELFEPEVRVW VREEKVNGKN LTDIFNAEHE NVRYLPKIKL PHNLIAEPDL 130 140 150 160 170 180 LKAVEGANII VFNLPHQFLA GVCKQLKGHV NPKARAISCL KGLDVTPQGV YLLSDVIENE 190 200 210 220 230 240 TGLHCGVLSG ANLATEIALE KYSETTVAYN RPKDFFGEGD VTNDVLKALF HRPYFHVRCV 250 260 270 280 290 300 QDVAGVSIGG ALKNVVALCA GFVEGKNWGD NAKAAIMRRG MLEMINFSKR FFPETDINTL 310 320 330 340 350 360 TVESAGVADL ITSCAGGRNF KVGRAFGKES GSGKTIQDVE KELLNGQSAQ GVITCNEVHE 370 380 390 LLKNKNMQKD FPLFESTWGI IHGELKIDDL PEILYHAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Glycerol 3 phosphate dehydrogenase from Yarrowia lipolityca." Nicaud J.-M., le Dall M.-T., Choquer M. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ250328 Genomic DNA. Translation: CAB58452.1. CR382128 Genomic DNA. Translation: CAG82664.1.
RefSeq	XP_500444.1. XM_500444.1.
3D structure databases
ProteinModelPortal	Q9UVF4.
ModBase	Search...
Protein-protein interaction databases
STRING	4952.Q9UVF4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2906777.
KEGG	yli:YALI0B02948g.
Phylogenomic databases
eggNOG	COG0240.
HOGENOM	HOG000246855.
KO	K00006.
OMA	PVGEFIH.
OrthoDB	EOG4FBN2Q.
Family and domain databases
Gene3D	1.10.1040.10. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR006168. G3P_DH_NAD-dep. IPR006109. G3P_DH_NAD-dep_C. IPR017751. G3P_DH_NAD-dep_euk. IPR011128. G3P_DH_NAD-dep_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11728. PTHR11728. 1 hit.
Pfam	PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view]
PIRSF	PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTS	PR00077. GPDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR03376. glycerol3P_DH. 1 hit.
PROSITE	PS00957. NAD_G3PDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPD1_YARLI

Accession

Primary (citable) accession number: Q9UVF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program