Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UVC3

- CP51_CUNEL

UniProt

Q9UVC3 - CP51_CUNEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lanosterol 14-alpha demethylase

Gene

CYP51

Organism
Cunninghamella elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).By similarity

Catalytic activityi

A 14-alpha-methylsteroid + 3 O2 + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP+ + 4 H2O.

Cofactori

hemeBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi458 – 4581Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. sterol 14-demethylase activity Source: UniProtKB-EC

GO - Biological processi

  1. sterol biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

UniPathwayiUPA00770; UER00754.

Names & Taxonomyi

Protein namesi
Recommended name:
Lanosterol 14-alpha demethylase (EC:1.14.13.70)
Alternative name(s):
CYPLI
Cytochrome P450 51
Cytochrome P450-14DM
Cytochrome P450-LIA1
Sterol 14-alpha demethylase
Gene namesi
Name:CYP51
OrganismiCunninghamella elegans
Taxonomic identifieri4853 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesCunninghamellaceaeCunninghamella

Subcellular locationi

Membrane Curated

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Lanosterol 14-alpha demethylasePRO_0000052006Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9UVC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UVC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIVSQISRF ITFTIISMGY SVLAVGVALT IHILSQLIVP KNPNEPPNVF
60 70 80 90 100
SLIPVLGNAV QFGMNPVAFL QECQKKYGDV FTFTMVGKRV TVCLGADGNQ
110 120 130 140 150
FVFNSKQNLS SAAEAYNHMT KYVFGPDVVY DAPHAVFMEQ KKFIKAGLNS
160 170 180 190 200
DCFRQHVPMI VQETEEFFKK FNKPTGFIEA YETFGSLIIY TASRCLMGKE
210 220 230 240 250
IRASLDGNVA KLYYDLDQGF KPINFIFPNL PLPSYRRRDV ACKKMADLYS
260 270 280 290 300
SIIQRRKDEK DNNNADLLQA LMDATYKDGT HIPDHHIAGM MIAVLFGGQH
310 320 330 340 350
TSATTSAWTI LELANRPDII KALREEQIEK LGSLKADLTF DNLKDLPLLE
360 370 380 390 400
AAIRETLRLH PPIFQMMRRV VADKIVYEKN GMEIPKGNFI CAAPGVTQVD
410 420 430 440 450
PTYFNEPTTY NPYRWIEKTD PVHQLEQGDD ANIDYGFGAV GISSKSPFLP
460 470 480 490 500
FGAGRHRCIG EQFGYLQLKT VISTFIRTFD FDLDGKSVPK SDYTSMVVVP
510
EHTAKVRYTW RE
Length:512
Mass (Da):57,677
Last modified:May 1, 2000 - v1
Checksum:i5E10C9D415CA15B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046863 Genomic DNA. Translation: AAF20263.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046863 Genomic DNA. Translation: AAF20263.1 .

3D structure databases

ProteinModelPortali Q9UVC3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00770 ; UER00754 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00465. EP450IV.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Craft D.L., Loper J.C.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 36112 / DSM 8217.

Entry informationi

Entry nameiCP51_CUNEL
AccessioniPrimary (citable) accession number: Q9UVC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3