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Q9UVC3

- CP51_CUNEL

UniProt

Q9UVC3 - CP51_CUNEL

Protein

Lanosterol 14-alpha demethylase

Gene

CYP51

Organism
Cunninghamella elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol By similarity.By similarity

    Catalytic activityi

    A 14-alpha-methylsteroid + 3 O2 + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP+ + 4 H2O.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi458 – 4581Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. sterol 14-demethylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sterol biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00770; UER00754.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lanosterol 14-alpha demethylase (EC:1.14.13.70)
    Alternative name(s):
    CYPLI
    Cytochrome P450 51
    Cytochrome P450-14DM
    Cytochrome P450-LIA1
    Sterol 14-alpha demethylase
    Gene namesi
    Name:CYP51
    OrganismiCunninghamella elegans
    Taxonomic identifieri4853 [NCBI]
    Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesCunninghamellaceaeCunninghamella

    Subcellular locationi

    Membrane Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Lanosterol 14-alpha demethylasePRO_0000052006Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UVC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00465. EP450IV.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UVC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIVSQISRF ITFTIISMGY SVLAVGVALT IHILSQLIVP KNPNEPPNVF    50
    SLIPVLGNAV QFGMNPVAFL QECQKKYGDV FTFTMVGKRV TVCLGADGNQ 100
    FVFNSKQNLS SAAEAYNHMT KYVFGPDVVY DAPHAVFMEQ KKFIKAGLNS 150
    DCFRQHVPMI VQETEEFFKK FNKPTGFIEA YETFGSLIIY TASRCLMGKE 200
    IRASLDGNVA KLYYDLDQGF KPINFIFPNL PLPSYRRRDV ACKKMADLYS 250
    SIIQRRKDEK DNNNADLLQA LMDATYKDGT HIPDHHIAGM MIAVLFGGQH 300
    TSATTSAWTI LELANRPDII KALREEQIEK LGSLKADLTF DNLKDLPLLE 350
    AAIRETLRLH PPIFQMMRRV VADKIVYEKN GMEIPKGNFI CAAPGVTQVD 400
    PTYFNEPTTY NPYRWIEKTD PVHQLEQGDD ANIDYGFGAV GISSKSPFLP 450
    FGAGRHRCIG EQFGYLQLKT VISTFIRTFD FDLDGKSVPK SDYTSMVVVP 500
    EHTAKVRYTW RE 512
    Length:512
    Mass (Da):57,677
    Last modified:May 1, 2000 - v1
    Checksum:i5E10C9D415CA15B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF046863 Genomic DNA. Translation: AAF20263.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF046863 Genomic DNA. Translation: AAF20263.1 .

    3D structure databases

    ProteinModelPortali Q9UVC3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00770 ; UER00754 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00465. EP450IV.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Craft D.L., Loper J.C.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 36112 / DSM 8217.

    Entry informationi

    Entry nameiCP51_CUNEL
    AccessioniPrimary (citable) accession number: Q9UVC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3