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Protein

Lanosterol 14-alpha demethylase

Gene

CYP51

Organism
Cunninghamella elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).By similarity

Catalytic activityi

A 14-alpha-methylsteroid + 3 O2 + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP+ + 4 H2O.

Cofactori

hemeBy similarity

Pathwayi: zymosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes zymosterol from lanosterol.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Lanosterol 14-alpha demethylase (CYP51)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway zymosterol biosynthesis, which is itself part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes zymosterol from lanosterol, the pathway zymosterol biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi458Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

UniPathwayiUPA00770; UER00754

Names & Taxonomyi

Protein namesi
Recommended name:
Lanosterol 14-alpha demethylase (EC:1.14.13.70)
Alternative name(s):
CYPLI
Cytochrome P450 51
Cytochrome P450-14DM
Cytochrome P450-LIA1
Sterol 14-alpha demethylase
Gene namesi
Name:CYP51
OrganismiCunninghamella elegans
Taxonomic identifieri4853 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMucoromycotaMucoromycotinaMucoralesCunninghamellaceaeCunninghamella

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000520061 – 512Lanosterol 14-alpha demethylaseAdd BLAST512

Proteomic databases

PRIDEiQ9UVC3

Structurei

3D structure databases

ProteinModelPortaliQ9UVC3
SMRiQ9UVC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002403 Cyt_P450_E_grp-IV
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00465 EP450IV
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UVC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVSQISRF ITFTIISMGY SVLAVGVALT IHILSQLIVP KNPNEPPNVF
60 70 80 90 100
SLIPVLGNAV QFGMNPVAFL QECQKKYGDV FTFTMVGKRV TVCLGADGNQ
110 120 130 140 150
FVFNSKQNLS SAAEAYNHMT KYVFGPDVVY DAPHAVFMEQ KKFIKAGLNS
160 170 180 190 200
DCFRQHVPMI VQETEEFFKK FNKPTGFIEA YETFGSLIIY TASRCLMGKE
210 220 230 240 250
IRASLDGNVA KLYYDLDQGF KPINFIFPNL PLPSYRRRDV ACKKMADLYS
260 270 280 290 300
SIIQRRKDEK DNNNADLLQA LMDATYKDGT HIPDHHIAGM MIAVLFGGQH
310 320 330 340 350
TSATTSAWTI LELANRPDII KALREEQIEK LGSLKADLTF DNLKDLPLLE
360 370 380 390 400
AAIRETLRLH PPIFQMMRRV VADKIVYEKN GMEIPKGNFI CAAPGVTQVD
410 420 430 440 450
PTYFNEPTTY NPYRWIEKTD PVHQLEQGDD ANIDYGFGAV GISSKSPFLP
460 470 480 490 500
FGAGRHRCIG EQFGYLQLKT VISTFIRTFD FDLDGKSVPK SDYTSMVVVP
510
EHTAKVRYTW RE
Length:512
Mass (Da):57,677
Last modified:May 1, 2000 - v1
Checksum:i5E10C9D415CA15B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046863 Genomic DNA Translation: AAF20263.1

Similar proteinsi

Entry informationi

Entry nameiCP51_CUNEL
AccessioniPrimary (citable) accession number: Q9UVC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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