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Q9UVC3

- CP51_CUNEL

UniProt

Q9UVC3 - CP51_CUNEL

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Protein
Lanosterol 14-alpha demethylase
Gene
CYP51
Organism
Cunninghamella elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol By similarity.

Catalytic activityi

A 14-alpha-methylsteroid + 3 O2 + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP+ + 4 H2O.

Cofactori

Heme group By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi458 – 4581Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. sterol 14-demethylase activity Source: UniProtKB-EC

GO - Biological processi

  1. sterol biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

UniPathwayiUPA00770; UER00754.

Names & Taxonomyi

Protein namesi
Recommended name:
Lanosterol 14-alpha demethylase (EC:1.14.13.70)
Alternative name(s):
CYPLI
Cytochrome P450 51
Cytochrome P450-14DM
Cytochrome P450-LIA1
Sterol 14-alpha demethylase
Gene namesi
Name:CYP51
OrganismiCunninghamella elegans
Taxonomic identifieri4853 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesCunninghamellaceaeCunninghamella

Subcellular locationi

Membrane Reviewed prediction

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Lanosterol 14-alpha demethylase
PRO_0000052006Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9UVC3.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UVC3-1 [UniParc]FASTAAdd to Basket

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MAIVSQISRF ITFTIISMGY SVLAVGVALT IHILSQLIVP KNPNEPPNVF    50
SLIPVLGNAV QFGMNPVAFL QECQKKYGDV FTFTMVGKRV TVCLGADGNQ 100
FVFNSKQNLS SAAEAYNHMT KYVFGPDVVY DAPHAVFMEQ KKFIKAGLNS 150
DCFRQHVPMI VQETEEFFKK FNKPTGFIEA YETFGSLIIY TASRCLMGKE 200
IRASLDGNVA KLYYDLDQGF KPINFIFPNL PLPSYRRRDV ACKKMADLYS 250
SIIQRRKDEK DNNNADLLQA LMDATYKDGT HIPDHHIAGM MIAVLFGGQH 300
TSATTSAWTI LELANRPDII KALREEQIEK LGSLKADLTF DNLKDLPLLE 350
AAIRETLRLH PPIFQMMRRV VADKIVYEKN GMEIPKGNFI CAAPGVTQVD 400
PTYFNEPTTY NPYRWIEKTD PVHQLEQGDD ANIDYGFGAV GISSKSPFLP 450
FGAGRHRCIG EQFGYLQLKT VISTFIRTFD FDLDGKSVPK SDYTSMVVVP 500
EHTAKVRYTW RE 512
Length:512
Mass (Da):57,677
Last modified:May 1, 2000 - v1
Checksum:i5E10C9D415CA15B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF046863 Genomic DNA. Translation: AAF20263.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF046863 Genomic DNA. Translation: AAF20263.1 .

3D structure databases

ProteinModelPortali Q9UVC3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00770 ; UER00754 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00465. EP450IV.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Craft D.L., Loper J.C.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 36112 / DSM 8217.

Entry informationi

Entry nameiCP51_CUNEL
AccessioniPrimary (citable) accession number: Q9UVC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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