Q9UV71 (AOX2_CANAX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alternative oxidase 2, mitochondrial
EC=1.-.-.-

Gene names

Name:	AOX2
Synonyms:	AOX1B

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures By similarity.
Cofactor	Binds 2 iron ions per subunit By similarity.
Subcellular location	Mitochondrion inner membrane; Single-pass membrane protein; Matrix side By similarity. Note: Possibly in the inner surface of the inner mitochondrial membrane By similarity.
Sequence similarities	Belongs to the alternative oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW respiratory gaseous exchange Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 365		Alternative oxidase 2, mitochondrial		PRO_0000001718
Regions
	Transmembrane	220 – 242	23	Helical; Potential
Sites
	Metal binding	166	1	Iron Potential
	Metal binding	205	1	Iron Potential
	Metal binding	208	1	Iron Potential
	Metal binding	257	1	Iron Potential
	Metal binding	312	1	Iron Potential
	Metal binding	315	1	Iron Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9UV71 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: CAFCB99F3608713F	FASTA	365	41,940
	10 20 30 40 50 60 MLTASLYKQL PVLTTTATST YSFIRLSSTL ATPPHSTTTT SPSSPAFHQP NHPQQFANPN 70 80 90 100 110 120 TSVFDVSTRI YTQEGIDNNN DTKFLTKAPY PHPVFPQDEC ENVTVTHRET KTLGDKISFR 130 140 150 160 170 180 SIQFMRQCFD LVTGYAVPKT NNPDEFKGTR WEMTEGKWLT RCIFLESVAG VPGSVAGFLR 190 200 210 220 230 240 HLHSLRMLRR DKAWIETLLD EAYNERMHLL TFIKIGKPSW FTRSIIYVGQ GVFTNVFFLL 250 260 270 280 290 300 YLLNPRYCHR FVGYLEEEAV RTYSHLLDEL AVPGKLPAFE TMKIPEVAVQ YWPELTPKSS 310 320 330 340 350 360 FKDLILRIRA DEAKHREVNH TFANLEQKTD RNPFALKIEG LNKPQPNHGI NVMRPTGWEK QDLQL

References

[1]	"Characterization of the gene family encoding alternative oxidase from Candida albicans." Huh W.-K., Kang S.-O. Biochem. J. 356:595-604(2001) [PubMed: 11368790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF116872 Genomic DNA. Translation: AAF21993.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UV71.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002680. AOX. [Graphical view]
Pfam	PF01786. AOX. 1 hit. [Graphical view]
PIRSF	PIRSF005229. AOX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AOX2_CANAX

Accession

Primary (citable) accession number: Q9UV71

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	May 1, 2000
Last modified:	October 19, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program