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Protein

Mitogen-activated protein kinase HOG1

Gene

HOG1

Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotation1
Active sitei144Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase HOG1 (EC:2.7.11.24)
Short name:
MAP kinase HOG1
Gene namesi
Name:HOG1
Ordered Locus Names:DEHA2E20944g
OrganismiDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
Taxonomic identifieri284592 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeDebaryomyces
Proteomesi
  • UP000000599 Componenti: Chromosome E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001863301 – 387Mitogen-activated protein kinase HOG1Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphothreonineBy similarity1
Modified residuei176PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-174 and Tyr-176, which activates the enzyme (By similarity). Phosphorylated in response of osmotic stress, oxidative stress and UV stress, but not heat stress.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9UV50

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9UV50
SMRiQ9UV50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 305Protein kinasePROSITE-ProRule annotationAdd BLAST283

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi174 – 176TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233024
InParanoidiQ9UV50
KOiK04441
OMAiDVIDTIC
OrthoDBiEOG092C2FL8

Family and domain databases

CDDicd07856 STKc_Sty1_Hog1, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR038783 MAPK_Sty1/Hog1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24055:SF247 PTHR24055:SF247, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UV50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSDGEFTRT QIFGTVFEIT NRYTDLNPVG MGAFGLVCSA IDKLTGQNVA
60 70 80 90 100
VKKIMKPFST SVLAKRTYRE LKLLKHLRHE NLITLDDIFL SPLEDIYFVT
110 120 130 140 150
ELQGTDLHRL LTSRPLEKQF IQYFTYQILR GLKYVHSAGV IHRDLKPSNI
160 170 180 190 200
LINENCDLKI CDFGLARIQD PQMTGYVSTR YYRAPEIMLT WQKYDTEVDL
210 220 230 240 250
WSVGCILSEM IEGKPLFPGK DHVHQFSIIT ELLGSPPPDV IETICSENTL
260 270 280 290 300
RFVQSLPHRD PIPFSERFAQ CSHVEPEAID LLAKMLIFDP KKRISALDAL
310 320 330 340 350
SHPYMEPYHD PTDEPVCEVK FDWSFNDADL PVDTWRVMMY SEILDFHQII
360 370 380
GAGANGTTQE QMAQIQQEGI QAPSSQYQQT NQEQKVE
Length:387
Mass (Da):44,357
Last modified:December 16, 2008 - v3
Checksum:i710908EC58AA0828
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272S → T in AAF24231 (PubMed:10620778).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF185278 Genomic DNA Translation: AAF24231.2
CR382137 Genomic DNA Translation: CAG88486.2
RefSeqiXP_460213.2, XM_460213.1

Genome annotation databases

EnsemblFungiiCAG88486; CAG88486; DEHA2E20944g
GeneIDi2902985
KEGGidha:DEHA2E20944g

Similar proteinsi

Entry informationi

Entry nameiHOG1_DEBHA
AccessioniPrimary (citable) accession number: Q9UV50
Secondary accession number(s): Q6BNK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: December 16, 2008
Last modified: May 23, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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