Reviewed, UniProtKB/Swiss-Prot Q9UUZ6 (RLA2_ASPFU)

Names and origin

Protein names

Recommended name:
    60S acidic ribosomal protein P2
Alternative name(s):
    AfP2
    Allergen=Asp f 8

Gene names

ORF Names:

AFUA_2G10100

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays an important role in the elongation step of protein synthesis.
Subunit structure	P1 and P2 exist as dimers at the large ribosomal subunit.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the ribosomal protein L12P family.

Ontologies

Keywords
Disease	Allergen
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translational elongation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 111	111	60S acidic ribosomal protein P2		PRO_0000157673
Amino acid modifications
	Modified residue	101	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	3	1	H → Y in CAB64688. Ref.1
	Sequence conflict	7	1	Y → F in CAB64688. Ref.1
	Sequence conflict	91	1	E → K in CAB64688. Ref.1
	Sequence conflict	94	1	K → N in CAB64688. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UUZ6-1 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 0B4C19B5CEE25471	FASTA	111	11,141
	10 20 30 40 50 60 MKHLAAYLLL ALAGNTSPSS EDVKAVLSSV GIDADEERLN KLIAELEGKD LQELIAEGST 70 80 90 100 110 KLASVPSGGA AAAAPAAAGA AAGGAAAPAA EEKKEEEKEE SDEDMGFGLF D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Highly conserved ribosomal proteins binding to serum IgE of Aspergillus fumigatus sensitized individuals." Hemmann S., Crameri R. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 42202 / AF-102 / Ag 507.
[2]	"Role of the ribosomal stalk components in the resistance of Aspergillus fumigatus to the sordarin antifungals." Santos C., Ballesta J.P.G. Mol. Microbiol. 43:227-237(2002) [PubMed: 11849550] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ224333 mRNA. Translation: CAB64688.1. AF268870 Genomic DNA. Translation: AAG01801.1. AAHF01000001 Genomic DNA. Translation: EAL93305.1.
RefSeq	XP_755343.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UUZ6.
Genome annotation databases
GeneID	3512932.
KEGG	afm:AFUA_2G10100.
Phylogenomic databases
HOGENOM	HBG744999.
OMA	VIGELNG.
OrthoDB	EOG99S7Q8.
Family and domain databases
InterPro	IPR001813. Ribosomal_60S. IPR001859. Ribosomal_P2. [Graphical view]
Pfam	PF00428. Ribosomal_60s. 1 hit. [Graphical view]
PRINTS	PR00456. RIBOSOMALP2.
ProtoNet	Search...

Entry information

Entry name

RLA2_ASPFU

Accession

Primary (citable) accession number: Q9UUZ6
Secondary accession number(s): Q4X1G0, Q9HGU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	December 6, 2005
Last modified:	December 15, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)