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Protein

Alpha-galactosidase C

Gene

aglC

Organism
Aspergillus niger
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in galactomannan degradation.1 Publication

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.1 Publication

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • NAD+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei508NucleophileBy similarity1
Active sitei534Proton donorBy similarity1

GO - Molecular functioni

  • alpha-galactosidase activity Source: UniProtKB
  • raffinose alpha-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  • carbohydrate catabolic process Source: UniProtKB

Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandMagnesium, NAD

Protein family/group databases

CAZyiGH36. Glycoside Hydrolase Family 36.
mycoCLAPiMEL36C_ASPNG.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-galactosidase C (EC:3.2.1.22)
Alternative name(s):
Melibiase
Gene namesi
Name:aglC1 Publication
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000102323 – 747Alpha-galactosidase CAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Glycosylationi425N-linked (GlcNAc...)Sequence analysis1
Glycosylationi429N-linked (GlcNAc...)Sequence analysis1
Glycosylationi450N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UUZ4.
PRIDEiQ9UUZ4.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi5061.CADANGAP00007429.

Chemistry databases

BindingDBiQ9UUZ4.

Structurei

3D structure databases

ProteinModelPortaliQ9UUZ4.
SMRiQ9UUZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 36 family.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3345. LUCA.

Family and domain databases

CDDicd14791. GH36. 1 hit.
Gene3Di2.60.40.1180. 1 hit.
3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR000111. Glyco_hydro_27/36_CS.
IPR002252. Glyco_hydro_36.
IPR031705. Glyco_hydro_36_C.
IPR031704. Glyco_hydro_36_N.
IPR013780. Glyco_hydro_b.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF16874. Glyco_hydro_36C. 1 hit.
PF16875. Glyco_hydro_36N. 1 hit.
PF02065. Melibiase. 1 hit.
PIRSFiPIRSF005536. Agal. 1 hit.
PRINTSiPR00743. GLHYDRLASE36.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00512. ALPHA_GALACTOSIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UUZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGSSHAVVA LGLFTLYGHS AAAPAIGASN SQTIVTNGTS FALNGDNVSY
60 70 80 90 100
RFHVNSSTGD LISDHFGGVV SGTIPSPVEP AVNGWVGMPG RIRREFPDQG
110 120 130 140 150
RGDFRIPAVR IRESAGYTVS DLQYVSHEVI EGKYALPGLP ATFGDAQDAT
160 170 180 190 200
TLVVHLYDNY SSVAADLSYS IFPKYDAIVR SVNVTNQGPG NITIEALASI
210 220 230 240 250
SIDFPYEDLD MVSLRGDWAR EANVQRSKVQ YGVQGFGSST GYSSHLHNPF
260 270 280 290 300
LAIVDPATTE SQGEAWGFNL VYTGSFSAQV EKGSQGFTRA LLGFNPDQLS
310 320 330 340 350
WNLGPGETLT SPECVAVYSD KGLGSVSRKF HRLYRNHLMK SKFATSDRPV
360 370 380 390 400
LLNSWEGVYF DYNQSSIETL AEESAALGVH LFVMDDGWFG DKYPRVSDNA
410 420 430 440 450
GLGDWMPNPA RFPDGLTPVV QDITNLTVNG TESTKLRFGI WVEPEMVNPN
460 470 480 490 500
STLYHEHPEW ALHAGPYPRT ERRNQLVLNL ALPAVQDFII DFMTNLLQDT
510 520 530 540 550
GISYVKWDNN RGIHETPSPS TDHQYMLGLY RVFDTLTTRF PDVLWEGCAS
560 570 580 590 600
GGGRFDAGML QYVPQIWTSD NTDAIDRITI QFGTSLAYPP SAMGAHLSAV
610 620 630 640 650
PNAQTGRTVP FTFRAHVAMM GGSFGLELDP ATVEGDEIVP ELLALAEKVN
660 670 680 690 700
PIILNGDLYR LRLPQDSQWP AALFVSQDGA QAVLFYFQVQ PNVNHAVPWV
710 720 730 740
RLQGLDPKAD YTVDGDQTYS GATLMNLGLQ YSFDTEYGSK VVFLERQ
Length:747
Mass (Da):81,859
Last modified:May 1, 2000 - v1
Checksum:i9429DAA59274ED00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251873 Genomic DNA. Translation: CAB63901.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251873 Genomic DNA. Translation: CAB63901.1.

3D structure databases

ProteinModelPortaliQ9UUZ4.
SMRiQ9UUZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00007429.

Chemistry databases

BindingDBiQ9UUZ4.
ChEMBLiCHEMBL3936.

Protein family/group databases

CAZyiGH36. Glycoside Hydrolase Family 36.
mycoCLAPiMEL36C_ASPNG.

Proteomic databases

PaxDbiQ9UUZ4.
PRIDEiQ9UUZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG3345. LUCA.

Family and domain databases

CDDicd14791. GH36. 1 hit.
Gene3Di2.60.40.1180. 1 hit.
3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR000111. Glyco_hydro_27/36_CS.
IPR002252. Glyco_hydro_36.
IPR031705. Glyco_hydro_36_C.
IPR031704. Glyco_hydro_36_N.
IPR013780. Glyco_hydro_b.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF16874. Glyco_hydro_36C. 1 hit.
PF16875. Glyco_hydro_36N. 1 hit.
PF02065. Melibiase. 1 hit.
PIRSFiPIRSF005536. Agal. 1 hit.
PRINTSiPR00743. GLHYDRLASE36.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00512. ALPHA_GALACTOSIDASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAGALC_ASPNG
AccessioniPrimary (citable) accession number: Q9UUZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 2000
Last modified: April 12, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.