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Protein

Alpha-galactosidase C

Gene

aglC

Organism
Aspergillus niger
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in galactomannan degradation.1 Publication

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.1 Publication

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • NAD+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei508NucleophileBy similarity1
Active sitei534Proton donorBy similarity1

GO - Molecular functioni

  • alpha-galactosidase activity Source: UniProtKB
  • raffinose alpha-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  • carbohydrate catabolic process Source: UniProtKB

Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandMagnesium, NAD

Protein family/group databases

CAZyiGH36 Glycoside Hydrolase Family 36
mycoCLAPiMEL36C_ASPNG

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-galactosidase C (EC:3.2.1.22)
Alternative name(s):
Melibiase
Gene namesi
Name:aglC1 Publication
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3936

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000102323 – 747Alpha-galactosidase CAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi450N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9UUZ4

Interactioni

Subunit structurei

Homotetramer.By similarity

Chemistry databases

BindingDBiQ9UUZ4

Structurei

3D structure databases

ProteinModelPortaliQ9UUZ4
SMRiQ9UUZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 36 family.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3345 LUCA

Family and domain databases

CDDicd14791 GH36, 1 hit
Gene3Di2.60.40.1180, 1 hit
2.70.98.60, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR038417 Alpga-gal_N_sf
IPR000111 Glyco_hydro_27/36_CS
IPR002252 Glyco_hydro_36
IPR031705 Glyco_hydro_36_C
IPR031704 Glyco_hydro_36_N
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF16874 Glyco_hydro_36C, 1 hit
PF16875 Glyco_hydro_36N, 1 hit
PF02065 Melibiase, 1 hit
PIRSFiPIRSF005536 Agal, 1 hit
PRINTSiPR00743 GLHYDRLASE36
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00512 ALPHA_GALACTOSIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UUZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGSSHAVVA LGLFTLYGHS AAAPAIGASN SQTIVTNGTS FALNGDNVSY
60 70 80 90 100
RFHVNSSTGD LISDHFGGVV SGTIPSPVEP AVNGWVGMPG RIRREFPDQG
110 120 130 140 150
RGDFRIPAVR IRESAGYTVS DLQYVSHEVI EGKYALPGLP ATFGDAQDAT
160 170 180 190 200
TLVVHLYDNY SSVAADLSYS IFPKYDAIVR SVNVTNQGPG NITIEALASI
210 220 230 240 250
SIDFPYEDLD MVSLRGDWAR EANVQRSKVQ YGVQGFGSST GYSSHLHNPF
260 270 280 290 300
LAIVDPATTE SQGEAWGFNL VYTGSFSAQV EKGSQGFTRA LLGFNPDQLS
310 320 330 340 350
WNLGPGETLT SPECVAVYSD KGLGSVSRKF HRLYRNHLMK SKFATSDRPV
360 370 380 390 400
LLNSWEGVYF DYNQSSIETL AEESAALGVH LFVMDDGWFG DKYPRVSDNA
410 420 430 440 450
GLGDWMPNPA RFPDGLTPVV QDITNLTVNG TESTKLRFGI WVEPEMVNPN
460 470 480 490 500
STLYHEHPEW ALHAGPYPRT ERRNQLVLNL ALPAVQDFII DFMTNLLQDT
510 520 530 540 550
GISYVKWDNN RGIHETPSPS TDHQYMLGLY RVFDTLTTRF PDVLWEGCAS
560 570 580 590 600
GGGRFDAGML QYVPQIWTSD NTDAIDRITI QFGTSLAYPP SAMGAHLSAV
610 620 630 640 650
PNAQTGRTVP FTFRAHVAMM GGSFGLELDP ATVEGDEIVP ELLALAEKVN
660 670 680 690 700
PIILNGDLYR LRLPQDSQWP AALFVSQDGA QAVLFYFQVQ PNVNHAVPWV
710 720 730 740
RLQGLDPKAD YTVDGDQTYS GATLMNLGLQ YSFDTEYGSK VVFLERQ
Length:747
Mass (Da):81,859
Last modified:May 1, 2000 - v1
Checksum:i9429DAA59274ED00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251873 Genomic DNA Translation: CAB63901.1

Similar proteinsi

Entry informationi

Entry nameiAGALC_ASPNG
AccessioniPrimary (citable) accession number: Q9UUZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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