Alpha-galactosidase C precursor - Aspergillus niger

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Q9UUZ4 (AGALC_ASPNG) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 59. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Alpha-galactosidase C
EC=3.2.1.22

Alternative name(s):
Melibiase

Gene names

Name:

aglC

Organism

Aspergillus niger

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	747 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in galactomannan degradation. Ref.1
Catalytic activity	Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. Ref.1
Cofactor	Magnesium By similarity. UniProtKB P27756 NAD By similarity. UniProtKB P27756
Subunit structure	Homotetramer By similarity. UniProtKB P27756
Sequence similarities	Belongs to the glycosyl hydrolase 36 family. UniProtKB P27756

Ontologies

Keywords
Domain	Signal
Ligand	Magnesium NAD
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from direct assay Ref.1. Source: UniProtKB
Molecular function	raffinose alpha-galactosidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

22

Potential

Chain

725

Alpha-galactosidase C

PRO_0000001023

Sites

Active site

1

Nucleophile By similarity

Active site

1

Proton donor By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9UUZ4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 9429DAA59274ED00
Show »

747

81,859

        10         20         30         40         50         60 
MIGSSHAVVA LGLFTLYGHS AAAPAIGASN SQTIVTNGTS FALNGDNVSY RFHVNSSTGD 

        70         80         90        100        110        120 
LISDHFGGVV SGTIPSPVEP AVNGWVGMPG RIRREFPDQG RGDFRIPAVR IRESAGYTVS 

       130        140        150        160        170        180 
DLQYVSHEVI EGKYALPGLP ATFGDAQDAT TLVVHLYDNY SSVAADLSYS IFPKYDAIVR 

       190        200        210        220        230        240 
SVNVTNQGPG NITIEALASI SIDFPYEDLD MVSLRGDWAR EANVQRSKVQ YGVQGFGSST 

       250        260        270        280        290        300 
GYSSHLHNPF LAIVDPATTE SQGEAWGFNL VYTGSFSAQV EKGSQGFTRA LLGFNPDQLS 

       310        320        330        340        350        360 
WNLGPGETLT SPECVAVYSD KGLGSVSRKF HRLYRNHLMK SKFATSDRPV LLNSWEGVYF 

       370        380        390        400        410        420 
DYNQSSIETL AEESAALGVH LFVMDDGWFG DKYPRVSDNA GLGDWMPNPA RFPDGLTPVV 

       430        440        450        460        470        480 
QDITNLTVNG TESTKLRFGI WVEPEMVNPN STLYHEHPEW ALHAGPYPRT ERRNQLVLNL 

       490        500        510        520        530        540 
ALPAVQDFII DFMTNLLQDT GISYVKWDNN RGIHETPSPS TDHQYMLGLY RVFDTLTTRF 

       550        560        570        580        590        600 
PDVLWEGCAS GGGRFDAGML QYVPQIWTSD NTDAIDRITI QFGTSLAYPP SAMGAHLSAV 

       610        620        630        640        650        660 
PNAQTGRTVP FTFRAHVAMM GGSFGLELDP ATVEGDEIVP ELLALAEKVN PIILNGDLYR 

       670        680        690        700        710        720 
LRLPQDSQWP AALFVSQDGA QAVLFYFQVQ PNVNHAVPWV RLQGLDPKAD YTVDGDQTYS 

       730        740 
GATLMNLGLQ YSFDTEYGSK VVFLERQ

References

[1]

"Cloning and characterization of Aspergillus niger genes encoding an alpha-galactosidase and a beta-mannosidase involved in galactomannan degradation."
Ademark P., de Vries R.P., Haegglund P., Staalbrand H., Visser J.
Eur. J. Biochem. 268:2982-2990(2001) [PubMed: 11358516] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY.
Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ251873 Genomic DNA. Translation: CAB63901.1.
3D structure databases
ProteinModelPortal	Q9UUZ4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UUZ4.
Protein family/group databases
CAZy	GH36. Glycoside Hydrolase Family 36.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
PhylomeDB	Q9UUZ4.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR002252. Glyco_hydro_36. IPR000111. Glyco_hydro_GHD. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF02065. Melibiase. 1 hit. [Graphical view]
PIRSF	PIRSF005536. Agal. 1 hit.
PRINTS	PR00743. GLHYDRLASE36.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS00512. ALPHA_GALACTOSIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AGALC_ASPNG

Accession

Primary (citable) accession number: Q9UUZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents