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Protein

Endo-xylogalacturonan hydrolase A

Gene

xghA

Organism
Aspergillus tubingensis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin. Activity requires a galacturonic acid backbone substituted with xylose.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei228 – 2281Proton donorBy similarity
Active sitei251 – 2511By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH28. Glycoside Hydrolase Family 28.
mycoCLAPiXGH28A_ASPTU.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-xylogalacturonan hydrolase A (EC:3.2.1.-)
Gene namesi
Name:xghA
OrganismiAspergillus tubingensis
Taxonomic identifieri5068 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 406388Endo-xylogalacturonan hydrolase APRO_0000394700Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence analysis
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Structurei

Secondary structure

1
406
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi50 – 6011Combined sources
Beta strandi65 – 684Combined sources
Beta strandi73 – 764Combined sources
Beta strandi86 – 927Combined sources
Beta strandi94 – 985Combined sources
Helixi102 – 1054Combined sources
Beta strandi109 – 1168Combined sources
Beta strandi118 – 1236Combined sources
Beta strandi125 – 1273Combined sources
Beta strandi130 – 1323Combined sources
Helixi136 – 1449Combined sources
Beta strandi152 – 1587Combined sources
Beta strandi160 – 1667Combined sources
Beta strandi168 – 1703Combined sources
Beta strandi176 – 1805Combined sources
Beta strandi183 – 19412Combined sources
Beta strandi198 – 2014Combined sources
Beta strandi208 – 2114Combined sources
Beta strandi213 – 22513Combined sources
Beta strandi230 – 2334Combined sources
Beta strandi237 – 24913Combined sources
Beta strandi253 – 2586Combined sources
Beta strandi260 – 2623Combined sources
Beta strandi264 – 27815Combined sources
Beta strandi280 – 2878Combined sources
Beta strandi297 – 32125Combined sources
Helixi326 – 3316Combined sources
Beta strandi337 – 35014Combined sources
Beta strandi352 – 3543Combined sources
Beta strandi357 – 3626Combined sources
Beta strandi367 – 37610Combined sources
Beta strandi386 – 3916Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C2LX-ray1.75A19-406[»]
ProteinModelPortaliQ9UUZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati183 – 21331PbH1 1Add
BLAST
Repeati214 – 25744PbH1 2Add
BLAST
Repeati266 – 28924PbH1 3Add
BLAST
Repeati299 – 32022PbH1 4Add
BLAST
Repeati333 – 37543PbH1 5Add
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 28 family.Curated
Contains 5 PbH1 repeats.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR000743. Glyco_hydro_28.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF00295. Glyco_hydro_28. 1 hit.
[Graphical view]
SMARTiSM00710. PbH1. 5 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UUZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALYRNLYLL ASLGLSSAAP SKVQRAPDSS IHARAVCTPT AGGDSSTDDV
60 70 80 90 100
PAITEALSSC GNGGTIVFPE GSTYYLNSVL DLGSCSDCDI QVEGLLKFAS
110 120 130 140 150
DTDYWSGRTA MISVSNVDGL KLRSLTGSGV IDGNGQDAWD LFASDSSYSR
160 170 180 190 200
PTLLYITGGS NLEISGLRQK NPPNVFNSVK GGATNVVFSN LKMDANSKSD
210 220 230 240 250
NPPKNTDGFD IGESTYVTIT EVTVVNDDDC VAFKPSSNYV TVDTISCTGS
260 270 280 290 300
HGISVGSLGK SSDDSVKNIY VTGATMINST KAAGIKTYPS GGDHGTSTVS
310 320 330 340 350
NVTFNDFTVD NSDYAFQIQS CYGEDDDYCE ENPGNAKLTD IVVSSFSGTT
360 370 380 390 400
SDKYDPVVAN LDCGADGTCG ISISGFDVKA PSGKSEVLCA NTPSDLGVTC

TSGASG
Length:406
Mass (Da):42,071
Last modified:May 1, 2000 - v1
Checksum:i190707D20C9D995E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249460 mRNA. Translation: CAB65657.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249460 mRNA. Translation: CAB65657.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C2LX-ray1.75A19-406[»]
ProteinModelPortaliQ9UUZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH28. Glycoside Hydrolase Family 28.
mycoCLAPiXGH28A_ASPTU.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR000743. Glyco_hydro_28.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF00295. Glyco_hydro_28. 1 hit.
[Graphical view]
SMARTiSM00710. PbH1. 5 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiXGHA_ASPTU
AccessioniPrimary (citable) accession number: Q9UUZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.