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Protein

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Gene

nubm

Organism
Yarrowia lipolytica (Candida lipolytica)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.Curated

Catalytic activityi

NADH + acceptor = NAD+ + reduced acceptor.Curated
NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).Curated

Cofactori

Protein has several cofactor binding sites:
  • FMNCurated
  • [4Fe-4S] clusterCurated

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase0 PublicationCurated
Biological processElectron transport, Respiratory chainCurated, Transport
Ligand4Fe-4SCurated, Flavoprotein, FMNCurated, Iron, Iron-sulfur, Metal-binding, NADCurated

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialCurated (EC:1.6.5.3Curated, EC:1.6.99.3Curated)
Gene namesi
Name:nubm0 Publication
Synonyms:NUO510 Publication
ORF Names:YALI1_B26679g0 Publication
OrganismiYarrowia lipolytica (Candida lipolytica)0 Publication
Taxonomic identifieri4952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000182444 Componenti: Chromosome 1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneCurated

Structurei

3D structure databases

ProteinModelPortaliQ9UUU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini366 – 411NADH_4Fe-4SImportedAdd BLAST46

Sequence similaritiesi

Belongs to the complex I 51 kDa subunit family.Curated

Keywords - Domaini

Transit peptideCurated

Phylogenomic databases

eggNOGiKOG2658. Eukaryota.
COG1894. LUCA.
HOGENOMiHOG000251534.

Family and domain databases

InterProiView protein in InterPro
IPR001949. NADH-UbQ_OxRdtase_51kDa_CS.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. Nuo51_FMN-bd.
IPR037225. Nuo51_FMN-bd_sf.
IPR019575. Nuop51_4Fe4S-bd.
IPR037207. Nuop51_4Fe4S-bd_sf.
IPR019554. Soluble_ligand-bd.
PfamiView protein in Pfam
PF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
SMARTiView protein in SMART
SM00928. NADH_4Fe-4S. 1 hit.
SUPFAMiSSF140490. SSF140490. 1 hit.
SSF142019. SSF142019. 1 hit.
TIGRFAMsiTIGR01959. nuoF_fam. 1 hit.
PROSITEiView protein in PROSITE
PS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UUU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRTTLHKRG LARLSRGFAT TQDATPKARQ YGGLKDQDRI FQNLYDNYGW
60 70 80 90 100
DLASARKQGD WYKTKELILK GDTWIIDEIK KSGLRGRGGA GFPSGLKWSF
110 120 130 140 150
MNPPGWEKNE GPRYLVVNAD EGEPGTCKDR EIMRKDPHKL VEGCLLAGRA
160 170 180 190 200
MNATAAYIYI RGEFYNEAAV LQTAINEAYA AGLIGKDACG SGYDFDVYIH
210 220 230 240 250
RGMGAYVCGE ETSLIESLEG KAGKPRLKPP FPAGVGLFGR PSTVTNVETV
260 270 280 290 300
AVAPTILRRG GDWFASFGRE RNSGTKLFCI SGNVNEPCTV EEEMSIPLRE
310 320 330 340 350
LLEKHCGGIK GGWDNLLGVI PGGCSVPILP KNICEDVLMD FDALKDVQSG
360 370 380 390 400
LGTAAVIVIN KQQDVIRAIQ RFAAFYKHES CGQCTPCREG TTWLLKAMDR
410 420 430 440 450
FRTGQAKERE IDMLYELTKD IEGHTICALG DAAAWPIQGL IRNFRPEMET
460 470 480
RMKKFHDEVG AVSVGGWMKD ARVEKGKVVG APLPGVHH
Length:488
Mass (Da):53,756
Last modified:May 1, 2000 - v1
Checksum:iE4897C8832E23891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF197536 Genomic DNA. Translation: AAF65194.2.
CP017554 Genomic DNA. Translation: AOW01975.1.
AJ249782 Genomic DNA. Translation: CAB65520.1.

Genome annotation databases

EnsemblFungiiAOW01975; AOW01975; YALI1_B26679g.

Similar proteinsi

Entry informationi

Entry nameiQ9UUU2_YARLL
AccessioniPrimary (citable) accession number: Q9UUU2
Secondary accession number(s): Q6CDX9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome0 Publication