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Q9UUQ6

- LCPS_MUCCL

UniProt

Q9UUQ6 - LCPS_MUCCL

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Protein
Bifunctional lycopene cyclase/phytoene synthase
Gene
CARRP
Organism
Mucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Bifunctional enzyme that catalyzes the reactions from prephytoene diphosphate to phytoene and lycopene to beta-carotene via the intermediate gamma-carotene.1 Publication

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro
  3. lycopene beta cyclase activity Source: UniProtKB
  4. phytoene synthase activity Source: UniProtKB

GO - Biological processi

  1. carotene biosynthetic process Source: GOC
  2. carotenoid biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Phytoene synthase (EC:2.5.1.32)
Gene namesi
Name:CARRP
OrganismiMucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
Taxonomic identifieri29924 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesMucorineaeMucoraceaeMucor

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed prediction
Add
BLAST
Transmembranei36 – 5621Helical; Reviewed prediction
Add
BLAST
Transmembranei70 – 9021Helical; Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Bifunctional lycopene cyclase/phytoene synthase
PRO_0000067441Add
BLAST

Expressioni

Inductioni

By blue light.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9UUQ6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 239239Lycopene beta-cyclase
Add
BLAST
Regioni246 – 614369Phytoene synthase
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.
In the C-terminal section; belongs to the phytoene/squalene synthase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UUQ6-1 [UniParc]FASTAAdd to Basket

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MLLTYMEVHL YYTLPVLGVL SWLSRPYYTA TDALKFKFLT LVAFTTASAW    50
DNYIVYHKAW SYCPTCVTAV IGYVPLEEYM FFIIMTLLTV AFTNLVMRWH 100
LHSFFIRPET PVMQSVLVRL VPITALLITA YKAWHLAVPG KPLFYGSCIL 150
WYACPVLALL WFGAGEYMMR RPLAVLVSIA LPTLFLCWVD VVAIGAGTWD 200
ISLATSTGKF VVPHLPVEEF MFFALINTVL VFGTCAIDRT MAILHLFKNK 250
SPYQRPYQHS KSFLHQILEM TWAFCLPDQV LHSDTFHDLS VSWDILRKAS 300
KSFYTASAVF PGDVRQELGV LYAFCRATDD LCDNEQVPVQ TRKEQLILTH 350
QFVSDLFGQK TSAPTAIDWD FYNDQLPASC ISAFKSFTRL RHVLEAGAIK 400
ELLDGYKWDL ERRSIRDQED LRYYSACVAS SVGEMCTRII LAHADKPASR 450
QQTQWIIQRA REMGLVLQYT NIARDIVTDS EELGRCYLPQ DWLTEKEVAL 500
IQGGLAREIG EERLLSLSHR LIYQADELMV VANKGIDKLP SHCQGGVRAA 550
CNVYASIGTK LKSYKHHYPS RAHVGNSKRV EIALLSVYNL YTAPIATSST 600
THCRQGKMRN LNTI 614
Length:614
Mass (Da):69,841
Last modified:May 1, 2000 - v1
Checksum:i599E6BB541087FE5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781E → K in strain: MS21; loss of lycopene cyclase activity. 1 Publication
Natural varianti86 – 861T → I in strain: MS35; loss of lycopene cyclase activity. 1 Publication
Natural varianti409 – 4091D → G in strain: MS36; loss of phytoene cyclase activity. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ250827 Genomic DNA. Translation: CAB60272.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ250827 Genomic DNA. Translation: CAB60272.1 .

3D structure databases

ProteinModelPortali Q9UUQ6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A bifunctional enzyme with lycopene cyclase and phytoene synthase activities is encoded by the carRP gene of Mucor circinelloides."
    Velayos A., Eslava A.P., Iturriaga E.A.
    Eur. J. Biochem. 267:5509-5519(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, VARIANTS LYS-78; ILE-86 AND GLY-409.
    Strain: ATCC 1216b / CBS 277.49 / NRRL 3631, MS21, MS35 and MS36.

Entry informationi

Entry nameiLCPS_MUCCL
AccessioniPrimary (citable) accession number: Q9UUQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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