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Q9UUQ6

- LCPS_MUCCL

UniProt

Q9UUQ6 - LCPS_MUCCL

Protein

Bifunctional lycopene cyclase/phytoene synthase

Gene

CARRP

Organism
Mucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Bifunctional enzyme that catalyzes the reactions from prephytoene diphosphate to phytoene and lycopene to beta-carotene via the intermediate gamma-carotene.1 Publication

    Catalytic activityi

    Carotenoid psi-end group = carotenoid beta-end group.
    2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

    Pathwayi

    GO - Molecular functioni

    1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
    2. intramolecular lyase activity Source: InterPro
    3. lycopene beta cyclase activity Source: UniProtKB
    4. phytoene synthase activity Source: UniProtKB

    GO - Biological processi

    1. carotene biosynthetic process Source: GOC
    2. carotenoid biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Isomerase, Transferase

    Keywords - Biological processi

    Carotenoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00799; UER00773.
    UPA00802.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional lycopene cyclase/phytoene synthase
    Including the following 2 domains:
    Lycopene beta-cyclase (EC:5.5.1.19)
    Phytoene synthase (EC:2.5.1.32)
    Gene namesi
    Name:CARRP
    OrganismiMucor circinelloides f. lusitanicus (Mucor racemosus var. lusitanicus)
    Taxonomic identifieri29924 [NCBI]
    Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesMucorineaeMucoraceaeMucor

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 614614Bifunctional lycopene cyclase/phytoene synthasePRO_0000067441Add
    BLAST

    Expressioni

    Inductioni

    By blue light.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UUQ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 239239Lycopene beta-cyclaseAdd
    BLAST
    Regioni246 – 614369Phytoene synthaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the lycopene beta-cyclase family.Curated
    In the C-terminal section; belongs to the phytoene/squalene synthase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00494. SQS_PSY. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
    PROSITEiPS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UUQ6-1 [UniParc]FASTAAdd to Basket

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    MLLTYMEVHL YYTLPVLGVL SWLSRPYYTA TDALKFKFLT LVAFTTASAW    50
    DNYIVYHKAW SYCPTCVTAV IGYVPLEEYM FFIIMTLLTV AFTNLVMRWH 100
    LHSFFIRPET PVMQSVLVRL VPITALLITA YKAWHLAVPG KPLFYGSCIL 150
    WYACPVLALL WFGAGEYMMR RPLAVLVSIA LPTLFLCWVD VVAIGAGTWD 200
    ISLATSTGKF VVPHLPVEEF MFFALINTVL VFGTCAIDRT MAILHLFKNK 250
    SPYQRPYQHS KSFLHQILEM TWAFCLPDQV LHSDTFHDLS VSWDILRKAS 300
    KSFYTASAVF PGDVRQELGV LYAFCRATDD LCDNEQVPVQ TRKEQLILTH 350
    QFVSDLFGQK TSAPTAIDWD FYNDQLPASC ISAFKSFTRL RHVLEAGAIK 400
    ELLDGYKWDL ERRSIRDQED LRYYSACVAS SVGEMCTRII LAHADKPASR 450
    QQTQWIIQRA REMGLVLQYT NIARDIVTDS EELGRCYLPQ DWLTEKEVAL 500
    IQGGLAREIG EERLLSLSHR LIYQADELMV VANKGIDKLP SHCQGGVRAA 550
    CNVYASIGTK LKSYKHHYPS RAHVGNSKRV EIALLSVYNL YTAPIATSST 600
    THCRQGKMRN LNTI 614
    Length:614
    Mass (Da):69,841
    Last modified:May 1, 2000 - v1
    Checksum:i599E6BB541087FE5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti78 – 781E → K in strain: MS21; loss of lycopene cyclase activity. 1 Publication
    Natural varianti86 – 861T → I in strain: MS35; loss of lycopene cyclase activity. 1 Publication
    Natural varianti409 – 4091D → G in strain: MS36; loss of phytoene cyclase activity. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250827 Genomic DNA. Translation: CAB60272.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ250827 Genomic DNA. Translation: CAB60272.1 .

    3D structure databases

    ProteinModelPortali Q9UUQ6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00799 ; UER00773 .
    UPA00802 .

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR017825. Lycopene_cyclase_dom.
    IPR002060. Squ/phyt_synthse.
    IPR019845. Squalene/phytoene_synthase_CS.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00494. SQS_PSY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
    PROSITEi PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A bifunctional enzyme with lycopene cyclase and phytoene synthase activities is encoded by the carRP gene of Mucor circinelloides."
      Velayos A., Eslava A.P., Iturriaga E.A.
      Eur. J. Biochem. 267:5509-5519(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, VARIANTS LYS-78; ILE-86 AND GLY-409.
      Strain: ATCC 1216b / CBS 277.49 / NRRL 3631, MS21, MS35 and MS36.

    Entry informationi

    Entry nameiLCPS_MUCCL
    AccessioniPrimary (citable) accession number: Q9UUQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3