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Protein

DNA repair protein rhp57

Gene

rhp57

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in recombination DNA repair and in the repair of gamma-ray-induced damage.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1078ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: InterPro
  • protein-DNA loading ATPase activity Source: PomBase

GO - Biological processi

  • DNA recombinase assembly Source: PomBase
  • double-strand break repair via homologous recombination Source: PomBase
  • reciprocal meiotic recombination Source: PomBase
  • strand invasion Source: PomBase
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein rhp57
Alternative name(s):
RAD57 homolog
Gene namesi
Name:rhp57
ORF Names:SPAC145.01, SPAC20H4.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20H4.07.
PomBaseiSPAC20H4.07.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • Rhp55-Rhp57 complex Source: PomBase
  • site of double-strand break Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354DNA repair protein rhp57PRO_0000122957Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rhp55O141294EBI-1996765,EBI-1996748

Protein-protein interaction databases

BioGridi278490. 232 interactions.
IntActiQ9UUL2. 2 interactions.
MINTiMINT-4715068.

Structurei

3D structure databases

ProteinModelPortaliQ9UUL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family.Curated

Phylogenomic databases

InParanoidiQ9UUL2.
KOiK10958.
OMAiLERRTHC.
OrthoDBiEOG7PP5GZ.
PhylomeDBiQ9UUL2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UUL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDISNYVDNF YFDEKIASAF ELGEVSTVDL LTLDITELER RTHCSQSELL
60 70 80 90 100
QLIEQISLLL QPVRCSASKV TSKYLTTGDV KLDETLHGGI PVGQLTEICG
110 120 130 140 150
ESGSGKSQFC MQLCLMVQLP LSLGGMNKAA VFISTESGLE TKRLFELARY
160 170 180 190 200
LPERYPKADK KDIIIKNPGD RVYTILCPDL ESQEHIIQYQ LPILFNRDKI
210 220 230 240 250
GLVILDSVAS NYRAELRYNR SKSHFRDLDN IAKRGNQLGK LAMTLRTLAH
260 270 280 290 300
QHEAAVVIAN QVSDRIPRDY DAIGLFSLDY QSQWFSGWDD TDPNPKIPSL
310 320 330 340 350
GLVWTNNIST RLALIKKTDS ATNNSGRIFR VVYSPNSPRL DVRICIGSVG

IYSC
Length:354
Mass (Da):39,731
Last modified:May 1, 2000 - v1
Checksum:i40131E247A087DB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024744 Genomic DNA. Translation: BAA83768.1.
CU329670 Genomic DNA. Translation: CAC19737.1.
PIRiT43507.
RefSeqiNP_593627.1. NM_001019058.2.

Genome annotation databases

EnsemblFungiiSPAC20H4.07.1; SPAC20H4.07.1:pep; SPAC20H4.07.
GeneIDi2542007.
KEGGispo:SPAC20H4.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024744 Genomic DNA. Translation: BAA83768.1.
CU329670 Genomic DNA. Translation: CAC19737.1.
PIRiT43507.
RefSeqiNP_593627.1. NM_001019058.2.

3D structure databases

ProteinModelPortaliQ9UUL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278490. 232 interactions.
IntActiQ9UUL2. 2 interactions.
MINTiMINT-4715068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC20H4.07.1; SPAC20H4.07.1:pep; SPAC20H4.07.
GeneIDi2542007.
KEGGispo:SPAC20H4.07.

Organism-specific databases

EuPathDBiFungiDB:SPAC20H4.07.
PomBaseiSPAC20H4.07.

Phylogenomic databases

InParanoidiQ9UUL2.
KOiK10958.
OMAiLERRTHC.
OrthoDBiEOG7PP5GZ.
PhylomeDBiQ9UUL2.

Miscellaneous databases

NextBioi20803087.
PROiQ9UUL2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A recombination repair gene of Schizosaccharomyces pombe, rhp57, is a functional homolog of the Saccharomyces cerevisiae RAD57 gene and is phylogenetically related to the human XRCC3 gene."
    Tsutsui Y., Morishita T., Iwasaki H., Toh H., Shinagawa H.
    Genetics 154:1451-1461(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiRAD57_SCHPO
AccessioniPrimary (citable) accession number: Q9UUL2
Secondary accession number(s): Q9P7A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.