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Q9UUK3

- OTU2_SCHPO

UniProt

Q9UUK3 - OTU2_SCHPO

Protein

Ubiquitin thioesterase otu2

Gene

otu2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: PomBase

    GO - Biological processi

    1. protein deubiquitination Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin thioesterase otu2 (EC:3.4.19.12)
    Alternative name(s):
    OTU domain-containing protein 2
    Gene namesi
    Name:otu2
    ORF Names:SPAC1952.03
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1952.03.

    Subcellular locationi

    Cytoplasm 2 Publications

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Ubiquitin thioesterase otu2PRO_0000318138Add
    BLAST

    Proteomic databases

    MaxQBiQ9UUK3.

    Interactioni

    Protein-protein interaction databases

    BioGridi279011. 29 interactions.
    MINTiMINT-4714941.
    STRINGi4896.SPAC1952.03-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UUK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini185 – 322138OTUPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5539.
    HOGENOMiHOG000192906.
    KOiK18342.
    OMAiKHVDDFL.
    OrthoDBiEOG73JM5N.
    PhylomeDBiQ9UUK3.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UUK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRCPLAYYYT QTTIPTQQKR KSKKMEELLS KQREECKELQ SKITNLRKQL    50
    KEGNKKQKRA LQQKISQMEA DLSQKHATER QKLDKGDEET NETQQEDLLN 100
    TLLQQMEDTK ITTAEKSSVQ SSLNTKENTP QQPKKSRNRQ KERLERRKAE 150
    MKKMSEQAEL ESEKMADLKN EEKKKFSKIL EEAGLVAVDI PADGNCLFAS 200
    ISHQLNYHHN VKLNSQALRN KSADYVLKHC EQFEGFLLDE ESGEVLPVSD 250
    YCNEIRNNSK WGSDIEIQAL ANSLEVPVHV YNTEGPVLKF NPSTVKFEKP 300
    LCIAYYQHLF GLGAHYNSLL YRDN 324
    Length:324
    Mass (Da):37,516
    Last modified:May 1, 2000 - v1
    Checksum:i48BBB435960D4B9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB52567.1.
    PIRiT37931.
    RefSeqiNP_594806.1. NM_001020234.2.

    Genome annotation databases

    EnsemblFungiiSPAC1952.03.1; SPAC1952.03.1:pep; SPAC1952.03.
    GeneIDi2542554.
    KEGGispo:SPAC1952.03.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB52567.1 .
    PIRi T37931.
    RefSeqi NP_594806.1. NM_001020234.2.

    3D structure databases

    ProteinModelPortali Q9UUK3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279011. 29 interactions.
    MINTi MINT-4714941.
    STRINGi 4896.SPAC1952.03-1.

    Proteomic databases

    MaxQBi Q9UUK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1952.03.1 ; SPAC1952.03.1:pep ; SPAC1952.03 .
    GeneIDi 2542554.
    KEGGi spo:SPAC1952.03.

    Organism-specific databases

    PomBasei SPAC1952.03.

    Phylogenomic databases

    eggNOGi COG5539.
    HOGENOMi HOG000192906.
    KOi K18342.
    OMAi KHVDDFL.
    OrthoDBi EOG73JM5N.
    PhylomeDBi Q9UUK3.

    Miscellaneous databases

    NextBioi 20803606.
    PROi Q9UUK3.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    3. "A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity."
      Kouranti I., McLean J.R., Feoktistova A., Liang P., Johnson A.E., Roberts-Galbraith R.H., Gould K.L.
      PLoS Biol. 8:708-716(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION.

    Entry informationi

    Entry nameiOTU2_SCHPO
    AccessioniPrimary (citable) accession number: Q9UUK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3