UniProtKB - Q9UUK2 (GCN5_SCHPO)
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Protein
Histone acetyltransferase gcn5
Gene
gcn5
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, and with a lower preference histone H4 to form H4K8ac and H4K16ac. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).By similarity1 Publication
Catalytic activityi
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 191 | Proton donor/acceptorBy similarity | 1 | |
Sitei | 191 | Important for catalytic activityBy similarity | 1 |
GO - Molecular functioni
- H3 histone acetyltransferase activity Source: PomBase
- histone acetyltransferase activity (H3-K14 specific) Source: PomBase
- histone acetyltransferase activity (H3-K9 specific) Source: PomBase
GO - Biological processi
- chromatin remodeling Source: PomBase
- histone H3 acetylation Source: PomBase
- negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter Source: PomBase
- negative regulation of leucine import across plasma membrane Source: PomBase
- reciprocal meiotic recombination Source: PomBase
- regulation of transcription by RNA polymerase II Source: PomBase
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, Acyltransferase, Chromatin regulator, Transferase |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-SPO-5689880 Ub-specific processing proteases |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:gcn5 ORF Names:SPAC1952.05 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPAC1952.05 |
PomBasei | SPAC1952.05 gcn5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211199 | 1 – 454 | Histone acetyltransferase gcn5Add BLAST | 454 |
Proteomic databases
MaxQBi | Q9UUK2 |
PaxDbi | Q9UUK2 |
PRIDEi | Q9UUK2 |
PTM databases
iPTMneti | Q9UUK2 |
Interactioni
Subunit structurei
Interacts with taf72.1 Publication
Protein-protein interaction databases
BioGridi | 278971272 interactors. |
IntActi | Q9UUK2 3 interactors. |
MINTi | Q9UUK2 |
STRINGi | 4896.SPAC1952.05.1 |
Structurei
3D structure databases
ProteinModelPortali | Q9UUK2 |
SMRi | Q9UUK2 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 273 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 156 | |
Domaini | 360 – 430 | BromoPROSITE-ProRule annotationAdd BLAST | 71 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 195 – 197 | Acetyl-CoA bindingBy similarity | 3 | |
Regioni | 202 – 208 | Acetyl-CoA bindingBy similarity | 7 | |
Regioni | 234 – 237 | Acetyl-CoA bindingBy similarity | 4 |
Sequence similaritiesi
Keywords - Domaini
BromodomainPhylogenomic databases
HOGENOMi | HOG000192257 |
InParanoidi | Q9UUK2 |
KOi | K06062 |
OMAi | GTIMQCS |
OrthoDBi | EOG092C0SVC |
PhylomeDBi | Q9UUK2 |
Family and domain databases
Gene3Di | 1.20.920.101 hit |
InterProi | View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR018359 Bromodomain_CS IPR037800 GCN5 IPR000182 GNAT_dom |
PANTHERi | PTHR22880:SF124 PTHR22880:SF124, 1 hit |
Pfami | View protein in Pfam PF00583 Acetyltransf_1, 1 hit PF00439 Bromodomain, 1 hit |
PRINTSi | PR00503 BROMODOMAIN |
SMARTi | View protein in SMART SM00297 BROMO, 1 hit |
SUPFAMi | SSF47370 SSF47370, 1 hit SSF55729 SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS00633 BROMODOMAIN_1, 1 hit PS50014 BROMODOMAIN_2, 1 hit PS51186 GNAT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UUK2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNSLNDQTR PPDSSVVDST SSNFPNASND SVHDKPVKQD EQSNPNVREA
60 70 80 90 100
IANSDGQESL AVKENKDTES SSSHFVPNGV SNSKKRKLVA TDLDVDFDIS
110 120 130 140 150
SVRVTEKPSV LEEKSGVIQF RVVSNDDTAD SMIMLTGLKN IFMKQLPKMP
160 170 180 190 200
KEYITRLIYD RNHLSMTIVK DNLHVVGGIT YRPFEQRGFA EIVFCAIASN
210 220 230 240 250
EQVRGYGSHL MNHLKDYVRG TTTIQHFLTY ADNYAIGYFK KQGFTKEITL
260 270 280 290 300
DKSIWVGYIK DYEGGTLMQC TMIPKIKYLE ANLILAIQKA AVVSKINRIT
310 320 330 340 350
RSNVVYPGLD VFKDGPAHIE PSQVPGLMEV GWCKEMEELS KKPRPKPFFA
360 370 380 390 400
VLEMLFTEMQ NHPSSWPFMQ PVSKEDVPDY YEVIEHPMDL STMEFRLRNN
410 420 430 440 450
QYESVEEFIR DAKYIFDNCR SYNDSNTTYY KNADRLEKFF QKKLRETEYS
HLAD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB162439 Genomic DNA Translation: BAD11106.1 CU329670 Genomic DNA Translation: CAB52569.1 |
PIRi | T37933 |
RefSeqi | NP_594807.1, NM_001020236.2 |
Genome annotation databases
EnsemblFungii | SPAC1952.05.1; SPAC1952.05.1:pep; SPAC1952.05 |
GeneIDi | 2542513 |
KEGGi | spo:SPAC1952.05 |
Similar proteinsi
Entry informationi
Entry namei | GCN5_SCHPO | |
Accessioni | Q9UUK2Primary (citable) accession number: Q9UUK2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |