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Protein

Histone acetyltransferase gcn5

Gene

gcn5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, and with a lower preference histone H4 to form H4K8ac and H4K16ac. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).By similarity1 Publication

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei191Proton donor/acceptorBy similarity1
Sitei191Important for catalytic activityBy similarity1

GO - Molecular functioni

  • H3 histone acetyltransferase activity Source: PomBase
  • histone acetyltransferase activity (H3-K14 specific) Source: PomBase
  • histone acetyltransferase activity (H3-K9 specific) Source: PomBase

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • histone H3 acetylation Source: PomBase
  • negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • negative regulation of leucine import across plasma membrane Source: PomBase
  • reciprocal meiotic recombination Source: PomBase
  • regulation of transcription by RNA polymerase II Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase gcn5 (EC:2.3.1.48)
Gene namesi
Name:gcn5
ORF Names:SPAC1952.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1952.05
PomBaseiSPAC1952.05 gcn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002111991 – 454Histone acetyltransferase gcn5Add BLAST454

Proteomic databases

MaxQBiQ9UUK2
PaxDbiQ9UUK2
PRIDEiQ9UUK2

PTM databases

iPTMnetiQ9UUK2

Interactioni

Subunit structurei

Interacts with taf72.1 Publication

Protein-protein interaction databases

BioGridi278971, 272 interactors
IntActiQ9UUK2, 3 interactors
MINTiQ9UUK2
STRINGi4896.SPAC1952.05.1

Structurei

3D structure databases

ProteinModelPortaliQ9UUK2
SMRiQ9UUK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 273N-acetyltransferasePROSITE-ProRule annotationAdd BLAST156
Domaini360 – 430BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni195 – 197Acetyl-CoA bindingBy similarity3
Regioni202 – 208Acetyl-CoA bindingBy similarity7
Regioni234 – 237Acetyl-CoA bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Bromodomain

Phylogenomic databases

HOGENOMiHOG000192257
InParanoidiQ9UUK2
KOiK06062
OMAiGTIMQCS
OrthoDBiEOG092C0SVC
PhylomeDBiQ9UUK2

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR037800 GCN5
IPR000182 GNAT_dom
PANTHERiPTHR22880:SF124 PTHR22880:SF124, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UUK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSLNDQTR PPDSSVVDST SSNFPNASND SVHDKPVKQD EQSNPNVREA
60 70 80 90 100
IANSDGQESL AVKENKDTES SSSHFVPNGV SNSKKRKLVA TDLDVDFDIS
110 120 130 140 150
SVRVTEKPSV LEEKSGVIQF RVVSNDDTAD SMIMLTGLKN IFMKQLPKMP
160 170 180 190 200
KEYITRLIYD RNHLSMTIVK DNLHVVGGIT YRPFEQRGFA EIVFCAIASN
210 220 230 240 250
EQVRGYGSHL MNHLKDYVRG TTTIQHFLTY ADNYAIGYFK KQGFTKEITL
260 270 280 290 300
DKSIWVGYIK DYEGGTLMQC TMIPKIKYLE ANLILAIQKA AVVSKINRIT
310 320 330 340 350
RSNVVYPGLD VFKDGPAHIE PSQVPGLMEV GWCKEMEELS KKPRPKPFFA
360 370 380 390 400
VLEMLFTEMQ NHPSSWPFMQ PVSKEDVPDY YEVIEHPMDL STMEFRLRNN
410 420 430 440 450
QYESVEEFIR DAKYIFDNCR SYNDSNTTYY KNADRLEKFF QKKLRETEYS

HLAD
Length:454
Mass (Da):51,976
Last modified:May 1, 2000 - v1
Checksum:iFF99039B00E8ECB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162439 Genomic DNA Translation: BAD11106.1
CU329670 Genomic DNA Translation: CAB52569.1
PIRiT37933
RefSeqiNP_594807.1, NM_001020236.2

Genome annotation databases

EnsemblFungiiSPAC1952.05.1; SPAC1952.05.1:pep; SPAC1952.05
GeneIDi2542513
KEGGispo:SPAC1952.05

Similar proteinsi

Entry informationi

Entry nameiGCN5_SCHPO
AccessioniPrimary (citable) accession number: Q9UUK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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