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Q9UUK2

- GCN5_SCHPO

UniProt

Q9UUK2 - GCN5_SCHPO

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Protein
Histone acetyltransferase gcn5
Gene
gcn5, SPAC1952.05
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, and with a lower preference histone H4 to form H4K8ac and H4K16ac. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.1 Publication

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei191 – 1911Important for catalytic activity By similarity

GO - Molecular functioni

  1. H3 histone acetyltransferase activity Source: PomBase

GO - Biological processi

  1. chromatin remodeling Source: PomBase
  2. histone H3 acetylation Source: PomBase
  3. negative regulation of leucine import Source: PomBase
  4. negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  5. reciprocal meiotic recombination Source: PomBase
  6. regulation of transcription from RNA polymerase II promoter Source: PomBase
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase gcn5 (EC:2.3.1.48)
Gene namesi
Name:gcn5
ORF Names:SPAC1952.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1952.05.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. SAGA complex Source: PomBase
  2. nuclear chromatin Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Histone acetyltransferase gcn5
PRO_0000211199Add
BLAST

Proteomic databases

MaxQBiQ9UUK2.

Interactioni

Subunit structurei

Interacts with taf72.1 Publication

Protein-protein interaction databases

BioGridi278971. 265 interactions.
IntActiQ9UUK2. 3 interactions.
MINTiMINT-8210502.
STRINGi4896.SPAC1952.05-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UUK2.
SMRiQ9UUK2. Positions 118-280.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 273156N-acetyltransferase
Add
BLAST
Domaini360 – 43071Bromo
Add
BLAST

Sequence similaritiesi

Contains 1 bromo domain.

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiCOG5076.
HOGENOMiHOG000192257.
KOiK06062.
OMAiDNCRKYN.
OrthoDBiEOG7XM37B.
PhylomeDBiQ9UUK2.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UUK2-1 [UniParc]FASTAAdd to Basket

« Hide

MSNSLNDQTR PPDSSVVDST SSNFPNASND SVHDKPVKQD EQSNPNVREA    50
IANSDGQESL AVKENKDTES SSSHFVPNGV SNSKKRKLVA TDLDVDFDIS 100
SVRVTEKPSV LEEKSGVIQF RVVSNDDTAD SMIMLTGLKN IFMKQLPKMP 150
KEYITRLIYD RNHLSMTIVK DNLHVVGGIT YRPFEQRGFA EIVFCAIASN 200
EQVRGYGSHL MNHLKDYVRG TTTIQHFLTY ADNYAIGYFK KQGFTKEITL 250
DKSIWVGYIK DYEGGTLMQC TMIPKIKYLE ANLILAIQKA AVVSKINRIT 300
RSNVVYPGLD VFKDGPAHIE PSQVPGLMEV GWCKEMEELS KKPRPKPFFA 350
VLEMLFTEMQ NHPSSWPFMQ PVSKEDVPDY YEVIEHPMDL STMEFRLRNN 400
QYESVEEFIR DAKYIFDNCR SYNDSNTTYY KNADRLEKFF QKKLRETEYS 450
HLAD 454
Length:454
Mass (Da):51,976
Last modified:May 1, 2000 - v1
Checksum:iFF99039B00E8ECB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB162439 Genomic DNA. Translation: BAD11106.1.
CU329670 Genomic DNA. Translation: CAB52569.1.
PIRiT37933.
RefSeqiNP_594807.1. NM_001020236.2.

Genome annotation databases

EnsemblFungiiSPAC1952.05.1; SPAC1952.05.1:pep; SPAC1952.05.
GeneIDi2542513.
KEGGispo:SPAC1952.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB162439 Genomic DNA. Translation: BAD11106.1 .
CU329670 Genomic DNA. Translation: CAB52569.1 .
PIRi T37933.
RefSeqi NP_594807.1. NM_001020236.2.

3D structure databases

ProteinModelPortali Q9UUK2.
SMRi Q9UUK2. Positions 118-280.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278971. 265 interactions.
IntActi Q9UUK2. 3 interactions.
MINTi MINT-8210502.
STRINGi 4896.SPAC1952.05-1.

Proteomic databases

MaxQBi Q9UUK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1952.05.1 ; SPAC1952.05.1:pep ; SPAC1952.05 .
GeneIDi 2542513.
KEGGi spo:SPAC1952.05.

Organism-specific databases

PomBasei SPAC1952.05.

Phylogenomic databases

eggNOGi COG5076.
HOGENOMi HOG000192257.
KOi K06062.
OMAi DNCRKYN.
OrthoDBi EOG7XM37B.
PhylomeDBi Q9UUK2.

Miscellaneous databases

NextBioi 20803566.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot."
    Yamada T., Mizuno K., Hirota K., Kon N., Wahls W.P., Hartsuiker E., Murofushi H., Shibata T., Ohta K.
    EMBO J. 23:1792-1803(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Two WD repeat-containing TATA-binding protein-associated factors in fission yeast that suppress defects in the anaphase-promoting complex."
    Mitsuzawa H., Seino H., Yamao F., Ishihama A.
    J. Biol. Chem. 276:17117-17124(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TAF72.

Entry informationi

Entry nameiGCN5_SCHPO
AccessioniPrimary (citable) accession number: Q9UUK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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