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Protein

Acetyl-CoA hydrolase

Gene

ach1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3015-glutamyl coenzyme A thioester intermediateBy similarity1
Binding sitei391Coenzyme ABy similarity1
Binding sitei395Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ach1
ORF Names:SPAC1952.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1952.09c
PomBaseiSPAC1952.09c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155221 – 521Acetyl-CoA hydrolaseAdd BLAST521

Proteomic databases

MaxQBiQ9UUJ9
PaxDbiQ9UUJ9
PRIDEiQ9UUJ9

PTM databases

SwissPalmiQ9UUJ9

Interactioni

Protein-protein interaction databases

BioGridi278973, 23 interactors
STRINGi4896.SPAC1952.09c.1

Structurei

3D structure databases

ProteinModelPortaliQ9UUJ9
SMRiQ9UUJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni276 – 280Coenzyme A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172597
InParanoidiQ9UUJ9
KOiK01067
OMAiDEALSWH
OrthoDBiEOG092C1EVJ
PhylomeDBiQ9UUJ9

Family and domain databases

Gene3Di3.40.1080.20, 1 hit
InterProiView protein in InterPro
IPR026888 AcetylCoA_hyd_C
IPR038460 AcetylCoA_hyd_C_sf
IPR003702 ActCoA_hydro
IPR037171 NagB/RpiA_transferase-like
PfamiView protein in Pfam
PF13336 AcetylCoA_hyd_C, 1 hit
PF02550 AcetylCoA_hydro, 1 hit
SUPFAMiSSF100950 SSF100950, 2 hits

Sequencei

Sequence statusi: Complete.

Q9UUJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLLSSRIR NAEFAKKIVT DPAKLVPYFK NGDYVGWSGF TGVGYPKMIP
60 70 80 90 100
NALARHVEEN NLQGKLRFKL FVGASGGADT ECKWAELNMI ERRCPHQVGK
110 120 130 140 150
PISKGINSGR IQFFDKHLSM FPQDLLYGYY TRNRESNTID TAIIEATAIT
160 170 180 190 200
EDGGIVPGAS VGASPELMQL AEKIIIEVNT AIPSFEGLHD IVEIPNPPHR
210 220 230 240 250
TPININRVDD RIGKPYIKVD PKKVIGIVEA DYGDITCANS PQDETSQAIA
260 270 280 290 300
GHLVDFFHHE VSVGRLPKNL HPLQSGIGNI ANAIIGGLAH SPFKDLEVWT
310 320 330 340 350
EVLQDTFLPL FDSEKLRFAT ATSTRFSPQG FEKFYSNYDY YKERILLRPQ
360 370 380 390 400
VISNHPEIIR RLGCIAMNTP VEADIYAHAN STNVLGSRML NGLGGSADFL
410 420 430 440 450
RNAKLSIMHT PSVRPSKKDP TGITCIVPMA THVDQTEHDL DILVTEQGLA
460 470 480 490 500
DLRGLSPTER AREVIDKCAH PDYKPLLREY FDIAENYCLA RGAGHEPHIL
510 520
ANAFKMQLNL LEKGTMKIDH W
Length:521
Mass (Da):57,916
Last modified:May 1, 2000 - v1
Checksum:i6053AD3CA38C7195
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223Missing in BAA13883 (PubMed:9501991).Curated1
Sequence conflicti486N → K in BAA13883 (PubMed:9501991).Curated1
Sequence conflicti511L → P in BAA13883 (PubMed:9501991).Curated1
Sequence conflicti521W → WCI in BAA13883 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB52573.1
D89222 mRNA Translation: BAA13883.1
PIRiT37937
T43043
RefSeqiNP_594811.1, NM_001020240.2

Genome annotation databases

EnsemblFungiiSPAC1952.09c.1; SPAC1952.09c.1:pep; SPAC1952.09c
GeneIDi2542515
KEGGispo:SPAC1952.09c

Similar proteinsi

Entry informationi

Entry nameiACH1_SCHPO
AccessioniPrimary (citable) accession number: Q9UUJ9
Secondary accession number(s): P78872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health