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Q9UUJ9 (ACH1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetyl-CoA hydrolase

EC=3.1.2.1
Alternative name(s):
Acetyl-CoA deacylase
Short name=Acetyl-CoA acylase
Gene names
Name:ach1
ORF Names:SPAC1952.09c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.

Catalytic activity

Acetyl-CoA + H2O = CoA + acetate.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the acetyl-CoA hydrolase/transferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521Acetyl-CoA hydrolase
PRO_0000215522

Experimental info

Sequence conflict2231Missing in BAA13883. Ref.2
Sequence conflict4861N → K in BAA13883. Ref.2
Sequence conflict5111L → P in BAA13883. Ref.2
Sequence conflict5211W → WCI in BAA13883. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9UUJ9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 6053AD3CA38C7195

FASTA52157,916
        10         20         30         40         50         60 
MPSLLSSRIR NAEFAKKIVT DPAKLVPYFK NGDYVGWSGF TGVGYPKMIP NALARHVEEN 

        70         80         90        100        110        120 
NLQGKLRFKL FVGASGGADT ECKWAELNMI ERRCPHQVGK PISKGINSGR IQFFDKHLSM 

       130        140        150        160        170        180 
FPQDLLYGYY TRNRESNTID TAIIEATAIT EDGGIVPGAS VGASPELMQL AEKIIIEVNT 

       190        200        210        220        230        240 
AIPSFEGLHD IVEIPNPPHR TPININRVDD RIGKPYIKVD PKKVIGIVEA DYGDITCANS 

       250        260        270        280        290        300 
PQDETSQAIA GHLVDFFHHE VSVGRLPKNL HPLQSGIGNI ANAIIGGLAH SPFKDLEVWT 

       310        320        330        340        350        360 
EVLQDTFLPL FDSEKLRFAT ATSTRFSPQG FEKFYSNYDY YKERILLRPQ VISNHPEIIR 

       370        380        390        400        410        420 
RLGCIAMNTP VEADIYAHAN STNVLGSRML NGLGGSADFL RNAKLSIMHT PSVRPSKKDP 

       430        440        450        460        470        480 
TGITCIVPMA THVDQTEHDL DILVTEQGLA DLRGLSPTER AREVIDKCAH PDYKPLLREY 

       490        500        510        520 
FDIAENYCLA RGAGHEPHIL ANAFKMQLNL LEKGTMKIDH W 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-521.
Strain: PR745.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAB52573.1.
D89222 mRNA. Translation: BAA13883.1.
PIRT37937.
T43043.
RefSeqNP_594811.1. NM_001020240.2.

3D structure databases

ProteinModelPortalQ9UUJ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid278973. 23 interactions.
MINTMINT-4714734.
STRING4896.SPAC1952.09c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC1952.09c.1; SPAC1952.09c.1:pep; SPAC1952.09c.
GeneID2542515.
KEGGspo:SPAC1952.09c.

Organism-specific databases

PomBaseSPAC1952.09c.

Phylogenomic databases

eggNOGCOG0427.
HOGENOMHOG000172597.
KOK01067.
OMAPHQVGKP.
OrthoDBEOG7TQV8M.
PhylomeDBQ9UUJ9.

Family and domain databases

InterProIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PANTHERPTHR21432:SF10. PTHR21432:SF10. 1 hit.
PfamPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803568.
PROQ9UUJ9.

Entry information

Entry nameACH1_SCHPO
AccessionPrimary (citable) accession number: Q9UUJ9
Secondary accession number(s): P78872
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names