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Q9UUJ9

- ACH1_SCHPO

UniProt

Q9UUJ9 - ACH1_SCHPO

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Protein

Acetyl-CoA hydrolase

Gene

ach1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei301 – 30115-glutamyl coenzyme A thioester intermediateBy similarity
Binding sitei391 – 3911Coenzyme ABy similarity
Binding sitei395 – 3951Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

  1. acetyl-CoA hydrolase activity Source: PomBase

GO - Biological processi

  1. acetate metabolic process Source: PomBase
  2. acetyl-CoA metabolic process Source: PomBase
  3. fatty acid biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ach1
ORF Names:SPAC1952.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1952.09c.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Acetyl-CoA hydrolasePRO_0000215522Add
BLAST

Proteomic databases

MaxQBiQ9UUJ9.

Interactioni

Protein-protein interaction databases

BioGridi278973. 23 interactions.
MINTiMINT-4714734.
STRINGi4896.SPAC1952.09c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UUJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni276 – 2805Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0427.
HOGENOMiHOG000172597.
InParanoidiQ9UUJ9.
KOiK01067.
OMAiECSAITE.
OrthoDBiEOG7TQV8M.
PhylomeDBiQ9UUJ9.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UUJ9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSLLSSRIR NAEFAKKIVT DPAKLVPYFK NGDYVGWSGF TGVGYPKMIP
60 70 80 90 100
NALARHVEEN NLQGKLRFKL FVGASGGADT ECKWAELNMI ERRCPHQVGK
110 120 130 140 150
PISKGINSGR IQFFDKHLSM FPQDLLYGYY TRNRESNTID TAIIEATAIT
160 170 180 190 200
EDGGIVPGAS VGASPELMQL AEKIIIEVNT AIPSFEGLHD IVEIPNPPHR
210 220 230 240 250
TPININRVDD RIGKPYIKVD PKKVIGIVEA DYGDITCANS PQDETSQAIA
260 270 280 290 300
GHLVDFFHHE VSVGRLPKNL HPLQSGIGNI ANAIIGGLAH SPFKDLEVWT
310 320 330 340 350
EVLQDTFLPL FDSEKLRFAT ATSTRFSPQG FEKFYSNYDY YKERILLRPQ
360 370 380 390 400
VISNHPEIIR RLGCIAMNTP VEADIYAHAN STNVLGSRML NGLGGSADFL
410 420 430 440 450
RNAKLSIMHT PSVRPSKKDP TGITCIVPMA THVDQTEHDL DILVTEQGLA
460 470 480 490 500
DLRGLSPTER AREVIDKCAH PDYKPLLREY FDIAENYCLA RGAGHEPHIL
510 520
ANAFKMQLNL LEKGTMKIDH W
Length:521
Mass (Da):57,916
Last modified:May 1, 2000 - v1
Checksum:i6053AD3CA38C7195
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231Missing in BAA13883. (PubMed:9501991)Curated
Sequence conflicti486 – 4861N → K in BAA13883. (PubMed:9501991)Curated
Sequence conflicti511 – 5111L → P in BAA13883. (PubMed:9501991)Curated
Sequence conflicti521 – 5211W → WCI in BAA13883. (PubMed:9501991)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB52573.1.
D89222 mRNA. Translation: BAA13883.1.
PIRiT37937.
T43043.
RefSeqiNP_594811.1. NM_001020240.2.

Genome annotation databases

EnsemblFungiiSPAC1952.09c.1; SPAC1952.09c.1:pep; SPAC1952.09c.
GeneIDi2542515.
KEGGispo:SPAC1952.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB52573.1 .
D89222 mRNA. Translation: BAA13883.1 .
PIRi T37937.
T43043.
RefSeqi NP_594811.1. NM_001020240.2.

3D structure databases

ProteinModelPortali Q9UUJ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278973. 23 interactions.
MINTi MINT-4714734.
STRINGi 4896.SPAC1952.09c-1.

Proteomic databases

MaxQBi Q9UUJ9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1952.09c.1 ; SPAC1952.09c.1:pep ; SPAC1952.09c .
GeneIDi 2542515.
KEGGi spo:SPAC1952.09c.

Organism-specific databases

PomBasei SPAC1952.09c.

Phylogenomic databases

eggNOGi COG0427.
HOGENOMi HOG000172597.
InParanoidi Q9UUJ9.
KOi K01067.
OMAi ECSAITE.
OrthoDBi EOG7TQV8M.
PhylomeDBi Q9UUJ9.

Miscellaneous databases

NextBioi 20803568.
PROi Q9UUJ9.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-521.
    Strain: PR745.

Entry informationi

Entry nameiACH1_SCHPO
AccessioniPrimary (citable) accession number: Q9UUJ9
Secondary accession number(s): P78872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3