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Q9UUJ9

- ACH1_SCHPO

UniProt

Q9UUJ9 - ACH1_SCHPO

Protein

Acetyl-CoA hydrolase

Gene

ach1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

    Catalytic activityi

    Acetyl-CoA + H2O = CoA + acetate.

    GO - Molecular functioni

    1. acetyl-CoA hydrolase activity Source: PomBase

    GO - Biological processi

    1. acetate metabolic process Source: PomBase
    2. acetyl-CoA metabolic process Source: PomBase
    3. fatty acid biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA hydrolase (EC:3.1.2.1)
    Alternative name(s):
    Acetyl-CoA deacylase
    Short name:
    Acetyl-CoA acylase
    Gene namesi
    Name:ach1
    ORF Names:SPAC1952.09c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1952.09c.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Acetyl-CoA hydrolasePRO_0000215522Add
    BLAST

    Proteomic databases

    MaxQBiQ9UUJ9.

    Interactioni

    Protein-protein interaction databases

    BioGridi278973. 23 interactions.
    MINTiMINT-4714734.
    STRINGi4896.SPAC1952.09c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UUJ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0427.
    HOGENOMiHOG000172597.
    KOiK01067.
    OMAiECSAITE.
    OrthoDBiEOG7TQV8M.
    PhylomeDBiQ9UUJ9.

    Family and domain databases

    InterProiIPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view]
    PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UUJ9-1 [UniParc]FASTAAdd to Basket

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    MPSLLSSRIR NAEFAKKIVT DPAKLVPYFK NGDYVGWSGF TGVGYPKMIP    50
    NALARHVEEN NLQGKLRFKL FVGASGGADT ECKWAELNMI ERRCPHQVGK 100
    PISKGINSGR IQFFDKHLSM FPQDLLYGYY TRNRESNTID TAIIEATAIT 150
    EDGGIVPGAS VGASPELMQL AEKIIIEVNT AIPSFEGLHD IVEIPNPPHR 200
    TPININRVDD RIGKPYIKVD PKKVIGIVEA DYGDITCANS PQDETSQAIA 250
    GHLVDFFHHE VSVGRLPKNL HPLQSGIGNI ANAIIGGLAH SPFKDLEVWT 300
    EVLQDTFLPL FDSEKLRFAT ATSTRFSPQG FEKFYSNYDY YKERILLRPQ 350
    VISNHPEIIR RLGCIAMNTP VEADIYAHAN STNVLGSRML NGLGGSADFL 400
    RNAKLSIMHT PSVRPSKKDP TGITCIVPMA THVDQTEHDL DILVTEQGLA 450
    DLRGLSPTER AREVIDKCAH PDYKPLLREY FDIAENYCLA RGAGHEPHIL 500
    ANAFKMQLNL LEKGTMKIDH W 521
    Length:521
    Mass (Da):57,916
    Last modified:May 1, 2000 - v1
    Checksum:i6053AD3CA38C7195
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti223 – 2231Missing in BAA13883. (PubMed:9501991)Curated
    Sequence conflicti486 – 4861N → K in BAA13883. (PubMed:9501991)Curated
    Sequence conflicti511 – 5111L → P in BAA13883. (PubMed:9501991)Curated
    Sequence conflicti521 – 5211W → WCI in BAA13883. (PubMed:9501991)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB52573.1.
    D89222 mRNA. Translation: BAA13883.1.
    PIRiT37937.
    T43043.
    RefSeqiNP_594811.1. NM_001020240.2.

    Genome annotation databases

    EnsemblFungiiSPAC1952.09c.1; SPAC1952.09c.1:pep; SPAC1952.09c.
    GeneIDi2542515.
    KEGGispo:SPAC1952.09c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB52573.1 .
    D89222 mRNA. Translation: BAA13883.1 .
    PIRi T37937.
    T43043.
    RefSeqi NP_594811.1. NM_001020240.2.

    3D structure databases

    ProteinModelPortali Q9UUJ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278973. 23 interactions.
    MINTi MINT-4714734.
    STRINGi 4896.SPAC1952.09c-1.

    Proteomic databases

    MaxQBi Q9UUJ9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1952.09c.1 ; SPAC1952.09c.1:pep ; SPAC1952.09c .
    GeneIDi 2542515.
    KEGGi spo:SPAC1952.09c.

    Organism-specific databases

    PomBasei SPAC1952.09c.

    Phylogenomic databases

    eggNOGi COG0427.
    HOGENOMi HOG000172597.
    KOi K01067.
    OMAi ECSAITE.
    OrthoDBi EOG7TQV8M.
    PhylomeDBi Q9UUJ9.

    Miscellaneous databases

    NextBioi 20803568.
    PROi Q9UUJ9.

    Family and domain databases

    InterProi IPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view ]
    Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
      Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
      DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-521.
      Strain: PR745.

    Entry informationi

    Entry nameiACH1_SCHPO
    AccessioniPrimary (citable) accession number: Q9UUJ9
    Secondary accession number(s): P78872
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3