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Protein

Putative alpha,alpha-trehalose-phosphate synthase [UDP-forming] 100 kDa subunit

Gene

SPAC22F8.05

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative alpha,alpha-trehalose-phosphate synthase [UDP-forming] 100 kDa subunit (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
ORF Names:SPAC22F8.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC22F8.05.
PomBaseiSPAC22F8.05.

Subcellular locationi

GO - Cellular componenti

  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 891891Putative alpha,alpha-trehalose-phosphate synthase [UDP-forming] 100 kDa subunitPRO_0000122513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei88 – 881Phosphothreonine1 Publication
Modified residuei108 – 1081Phosphoserine1 Publication
Modified residuei109 – 1091Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UUI7.

Interactioni

Protein-protein interaction databases

BioGridi278393. 28 interactions.
MINTiMINT-4714293.

Structurei

3D structure databases

ProteinModelPortaliQ9UUI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 613482GlycosyltransferaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated

Phylogenomic databases

eggNOGiCOG0380.
HOGENOMiHOG000179930.
InParanoidiQ9UUI7.
KOiK16055.
OMAiTCHEFIL.
OrthoDBiEOG76QFS6.
PhylomeDBiQ9UUI7.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
IPR003337. Trehalose_PPase.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
PF02358. Trehalose_PPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UUI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRQFICSIY LPYTINFHLD ELEGNHESHP AITHQEKVTQ THRDSVKIDD
60 70 80 90 100
ILTRLSISKS ESGQATPVLT PQLEGMNDYF SLGPSKRTGG SMTPGLGAMS
110 120 130 140 150
PIPGSGRSSP LYTQPRSRAT SPSRVRQADR FAAPGIGAGA LPIRRKRRDS
160 170 180 190 200
LAKSVALFES ARWSVERGVV GNSGLFHAVD AAVRDHGLQN PLWVGLLGMP
210 220 230 240 250
TESLSEKTKN AISGALLVKH QSLVVYTSDS NFEGHYNHYC RKILWPSLHY
260 270 280 290 300
QHNEIFSFFH EESNWDDYVA VNRAFADALI KNYKTGDTIW VNDYHLLLVP
310 320 330 340 350
NMVRERIPSA IIGLFIHVSF PSSEVFRCFA RRKELLQGML GSNLIGFQTE
360 370 380 390 400
EYKRHFLQSC SRVLYAESTF DRILLDDRYI DVYAHPIGAD PVLVDKWLEN
410 420 430 440 450
PETLEVKEVL EKRYANLNIF VGCDKMDPIR GIREKLLAFE QFLYDNPEYQ
460 470 480 490 500
KNTILIQTST FTEEQKEYGV AISDIVTRIN SAFGDFSLDH LPVTILSSDL
510 520 530 540 550
SYPQYLALLS VADAFIVTSL REGMSLTCHE FILTQRQKKS PLIVSEFIGC
560 570 580 590 600
ASMFSNGAFI VNPWSTLELS LSMKKALTLS TNERNQRYSN CLDVVLTHSA
610 620 630 640 650
SNWVTGFETK LKKSWTSQQK RDFSRLPRFT LNFIGNRYDH AKKRLLILNF
660 670 680 690 700
DGNAVTWEGR HEFVDFHYGY MVSILSKLIA DDRNIVYIAS CLEEDELESL
710 720 730 740 750
FMHVPGVGLI AENGCYVLPH YAENVHQSWI RLYKKQQMDW REPLHDIIQY
760 770 780 790 800
YSERTPGSSL IDHGFAMEFN YVKAENRENG LRSAGELASS INETQHGCRA
810 820 830 840 850
VPLDGRVLCE PTTISKATAA NYIMTHLIKN PEELDLILVA GNNRTDESVF
860 870 880 890
AWANKSKVSS FTVSMGVGNT EAKAYTDGIP SFFNVLNSLC A
Length:891
Mass (Da):100,661
Last modified:May 1, 2000 - v1
Checksum:i7F74688CCBFC45B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB52715.1.
PIRiT38195.
RefSeqiNP_594728.1. NM_001020156.2.

Genome annotation databases

EnsemblFungiiSPAC22F8.05.1; SPAC22F8.05.1:pep; SPAC22F8.05.
GeneIDi2541903.
KEGGispo:SPAC22F8.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB52715.1.
PIRiT38195.
RefSeqiNP_594728.1. NM_001020156.2.

3D structure databases

ProteinModelPortaliQ9UUI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278393. 28 interactions.
MINTiMINT-4714293.

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Proteomic databases

MaxQBiQ9UUI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC22F8.05.1; SPAC22F8.05.1:pep; SPAC22F8.05.
GeneIDi2541903.
KEGGispo:SPAC22F8.05.

Organism-specific databases

EuPathDBiFungiDB:SPAC22F8.05.
PomBaseiSPAC22F8.05.

Phylogenomic databases

eggNOGiCOG0380.
HOGENOMiHOG000179930.
InParanoidiQ9UUI7.
KOiK16055.
OMAiTCHEFIL.
OrthoDBiEOG76QFS6.
PhylomeDBiQ9UUI7.

Miscellaneous databases

NextBioi20802990.
PROiQ9UUI7.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
IPR003337. Trehalose_PPase.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
PF02358. Trehalose_PPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-88; SER-108 AND SER-109, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiTPSY_SCHPO
AccessioniPrimary (citable) accession number: Q9UUI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.