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Protein

Transcriptional repressor tup12

Gene

tup12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor.

GO - Molecular functioni

  • histone binding Source: PomBase

GO - Biological processi

  • carbon catabolite repression of of transcription by glucose Source: PomBase
  • chromatin remodeling in response to cation stress Source: PomBase
  • chromatin silencing Source: PomBase
  • negative regulation of transcription by RNA polymerase II Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor tup12
Gene namesi
Name:tup12
Synonyms:tup1
ORF Names:SPAC630.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC630.14c
PomBaseiSPAC630.14c tup12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513111 – 598Transcriptional repressor tup12Add BLAST598

Proteomic databases

MaxQBiQ9UUG8
PaxDbiQ9UUG8
PRIDEiQ9UUG8

PTM databases

iPTMnetiQ9UUG8

Interactioni

GO - Molecular functioni

  • histone binding Source: PomBase

Protein-protein interaction databases

BioGridi279824, 15 interactors
STRINGi4896.SPAC630.14c.1

Structurei

3D structure databases

ProteinModelPortaliQ9UUG8
SMRiQ9UUG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati285 – 325WD 1Add BLAST41
Repeati332 – 371WD 2Add BLAST40
Repeati374 – 413WD 3Add BLAST40
Repeati415 – 454WD 4Add BLAST40
Repeati456 – 495WD 5Add BLAST40
Repeati510 – 549WD 6Add BLAST40
Repeati552 – 585WD 7Add BLAST34

Sequence similaritiesi

Belongs to the WD repeat TUP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000200558
InParanoidiQ9UUG8
KOiK06666
OrthoDBiEOG092C21A7

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR013890 Tscrpt_rep_Tup1_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08581 Tup_N, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010558 Transcrip_repressor_Tup1_N, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UUG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFLVISQTT SFMITVRQFT FTIFKFQFMA TSNVSSRVNE LLEAVKKEFE
60 70 80 90 100
DICQKTKTVE AQKDDFEYKA MISAQINEMA LMKQTVMDLE MQQSKVKDRY
110 120 130 140 150
EEEITSLKAQ LEARRKEIAS GVVPQSSKTK HGRNSVSFGK YGNAGPFNSD
160 170 180 190 200
NSSKPLILNN GSSGGTPKNL RSPAIDSDGT VLAPIQTSNV DLGSQYYSSP
210 220 230 240 250
HVRPAVGATM AGSAMRTFPS NLPLGHPPPP SDSANSSVTP IAAPLVVNGK
260 270 280 290 300
VSGNPPYPAE IIPTSNVPNR EEKDWTVTSN VPNKEPPISV QLLHTLEHTS
310 320 330 340 350
VICYVRFSAD GKFLATGCNR AAMVFNVETG KLITLLQEES SKREGDLYVR
360 370 380 390 400
SVAFSPDGKY LATGVEDQQI RIWDIAQKRV YRLLTGHEQE IYSLDFSKDG
410 420 430 440 450
KTLVSGSGDR TVCLWDVEAG EQKLILHTDD GVTTVMFSPD GQFIAAGSLD
460 470 480 490 500
KVIRIWTSSG TLVEQLHGHE ESVYSVAFSP DGKYLVSGSL DNTIKLWELQ
510 520 530 540 550
CVSNVAPSMY KEGGICKQTF TGHKDFILSV TVSPDGKWII SGSKDRTIQF
560 570 580 590
WSPDSPHSQL TLQGHNNSVI SVAVSPNGHC FATGSGDLRA RIWSYEDL
Length:598
Mass (Da):65,561
Last modified:April 18, 2012 - v2
Checksum:iA9E9BAAB05471308
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB52736.2
U92792 mRNA Translation: AAB81475.2
PIRiT38992
RefSeqiNP_592910.2, NM_001018310.2

Genome annotation databases

EnsemblFungiiSPAC630.14c.1; SPAC630.14c.1:pep; SPAC630.14c
GeneIDi2543402
KEGGispo:SPAC630.14c

Similar proteinsi

Entry informationi

Entry nameiTUP12_SCHPO
AccessioniPrimary (citable) accession number: Q9UUG8
Secondary accession number(s): O14432
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: April 18, 2012
Last modified: April 25, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health