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Protein

Transcriptional repressor tup12

Gene

tup12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor.

GO - Molecular functioni

  • histone binding Source: PomBase

GO - Biological processi

  • chromatin remodeling in response to cation stress Source: PomBase
  • chromatin silencing Source: PomBase
  • negative regulation of transcription by glucose Source: PomBase
  • negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor tup12
Gene namesi
Name:tup12
Synonyms:tup1
ORF Names:SPAC630.14c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC630.14c.
PomBaseiSPAC630.14c. tup12.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nuclear chromatin Source: PomBase
  • nuclear transcriptional repressor complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513111 – 598Transcriptional repressor tup12Add BLAST598

Proteomic databases

MaxQBiQ9UUG8.
PRIDEiQ9UUG8.

Interactioni

GO - Molecular functioni

  • histone binding Source: PomBase

Protein-protein interaction databases

BioGridi279824. 13 interactors.
MINTiMINT-730889.

Structurei

3D structure databases

ProteinModelPortaliQ9UUG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati285 – 325WD 1Add BLAST41
Repeati332 – 371WD 2Add BLAST40
Repeati374 – 413WD 3Add BLAST40
Repeati415 – 454WD 4Add BLAST40
Repeati456 – 495WD 5Add BLAST40
Repeati510 – 549WD 6Add BLAST40
Repeati552 – 585WD 7Add BLAST34

Sequence similaritiesi

Belongs to the WD repeat TUP1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000200558.
InParanoidiQ9UUG8.
KOiK06666.
OMAiGKKSSCD.
OrthoDBiEOG092C21A7.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR013890. Tscrpt_rep_Tup1_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08581. Tup_N. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
ProDomiPD010558. Transcrip_repressor_Tup1_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UUG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFLVISQTT SFMITVRQFT FTIFKFQFMA TSNVSSRVNE LLEAVKKEFE
60 70 80 90 100
DICQKTKTVE AQKDDFEYKA MISAQINEMA LMKQTVMDLE MQQSKVKDRY
110 120 130 140 150
EEEITSLKAQ LEARRKEIAS GVVPQSSKTK HGRNSVSFGK YGNAGPFNSD
160 170 180 190 200
NSSKPLILNN GSSGGTPKNL RSPAIDSDGT VLAPIQTSNV DLGSQYYSSP
210 220 230 240 250
HVRPAVGATM AGSAMRTFPS NLPLGHPPPP SDSANSSVTP IAAPLVVNGK
260 270 280 290 300
VSGNPPYPAE IIPTSNVPNR EEKDWTVTSN VPNKEPPISV QLLHTLEHTS
310 320 330 340 350
VICYVRFSAD GKFLATGCNR AAMVFNVETG KLITLLQEES SKREGDLYVR
360 370 380 390 400
SVAFSPDGKY LATGVEDQQI RIWDIAQKRV YRLLTGHEQE IYSLDFSKDG
410 420 430 440 450
KTLVSGSGDR TVCLWDVEAG EQKLILHTDD GVTTVMFSPD GQFIAAGSLD
460 470 480 490 500
KVIRIWTSSG TLVEQLHGHE ESVYSVAFSP DGKYLVSGSL DNTIKLWELQ
510 520 530 540 550
CVSNVAPSMY KEGGICKQTF TGHKDFILSV TVSPDGKWII SGSKDRTIQF
560 570 580 590
WSPDSPHSQL TLQGHNNSVI SVAVSPNGHC FATGSGDLRA RIWSYEDL
Length:598
Mass (Da):65,561
Last modified:April 18, 2012 - v2
Checksum:iA9E9BAAB05471308
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB52736.2.
U92792 mRNA. Translation: AAB81475.2.
PIRiT38992.
RefSeqiNP_592910.2. NM_001018310.2.

Genome annotation databases

EnsemblFungiiSPAC630.14c.1; SPAC630.14c.1:pep; SPAC630.14c.
GeneIDi2543402.
KEGGispo:SPAC630.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB52736.2.
U92792 mRNA. Translation: AAB81475.2.
PIRiT38992.
RefSeqiNP_592910.2. NM_001018310.2.

3D structure databases

ProteinModelPortaliQ9UUG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279824. 13 interactors.
MINTiMINT-730889.

Proteomic databases

MaxQBiQ9UUG8.
PRIDEiQ9UUG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC630.14c.1; SPAC630.14c.1:pep; SPAC630.14c.
GeneIDi2543402.
KEGGispo:SPAC630.14c.

Organism-specific databases

EuPathDBiFungiDB:SPAC630.14c.
PomBaseiSPAC630.14c. tup12.

Phylogenomic databases

HOGENOMiHOG000200558.
InParanoidiQ9UUG8.
KOiK06666.
OMAiGKKSSCD.
OrthoDBiEOG092C21A7.

Miscellaneous databases

PROiQ9UUG8.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR013890. Tscrpt_rep_Tup1_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08581. Tup_N. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
ProDomiPD010558. Transcrip_repressor_Tup1_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTUP12_SCHPO
AccessioniPrimary (citable) accession number: Q9UUG8
Secondary accession number(s): O14432
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: April 18, 2012
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.