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Protein

Deoxyribonuclease Tat-D

Gene

pi038

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has both endo- and exonuclease activities. Incises double-stranded DNA without obvious specificity via its endonuclease activity and excises the DNA from the 3'-to 5'-end by its exonuclease activity. May have a role in apoptosis (By similarity).By similarity

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi124Divalent metal cation 1By similarity1
Metal bindingi124Divalent metal cation 2By similarity1
Metal bindingi161Divalent metal cation 2By similarity1
Metal bindingi187Divalent metal cation 2By similarity1
Metal bindingi235Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribonuclease Tat-D (EC:3.1.21.-)
Gene namesi
ORF Names:pi038, SPBC17A3.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC17A3.08.
PomBaseiSPBC17A3.08.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003170861 – 312Deoxyribonuclease Tat-DAdd BLAST312

Proteomic databases

MaxQBiQ9UUF1.
PRIDEiQ9UUF1.

Interactioni

Protein-protein interaction databases

BioGridi276447. 5 interactors.
MINTiMINT-4712897.
STRINGi4896.SPBC17A3.08.1.

Structurei

3D structure databases

ProteinModelPortaliQ9UUF1.
SMRiQ9UUF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000201523.
InParanoidiQ9UUF1.
KOiK03424.
OMAiRNEPCAL.
OrthoDBiEOG092C3EIV.
PhylomeDBiQ9UUF1.

Family and domain databases

CDDicd01310. TatD_DNAse. 1 hit.
InterProiView protein in InterPro
IPR032466. Metal_Hydrolase.
IPR001130. TatD_family.
PANTHERiPTHR10060. PTHR10060. 1 hit.
PfamiView protein in Pfam
PF01026. TatD_DNase. 1 hit.
PIRSFiPIRSF005902. DNase_TatD. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UUF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIRQAFVK SLRFYDIGYN ATDPVFRGIY HEKLKHPDDF DSIISRAKAV
60 70 80 90 100
GVEKMMITGD NVENSEEALN LATNYECFTS TVGVHPCQAQ CFLRHSEGPE
110 120 130 140 150
DYLVKLEALA NKGKASGKVV AFGEFGLDYD RLHYAPADVQ KMYFEEQLKV
160 170 180 190 200
AVRVQLPLFL HSRNAENDFF AILEKYLPEL PKKGVVHSFT GSIDEMRRCI
210 220 230 240 250
EHGLYVGVNG CSLKTEENLE VVRAIPLEKM LLETDAPWCE VRPSHAGHQF
260 270 280 290 300
LKTKLPFDSC KKERFKEGCM IRGRNEPCNT YIVAEIVAAL KDISLEELSE
310
QIWENSINLL SK
Length:312
Mass (Da):35,389
Last modified:May 1, 2000 - v1
Checksum:i6743BABB2BD5F409
GO

Sequence cautioni

The sequence BAA21418 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004537 Genomic DNA. Translation: BAA21418.1. Sequence problems.
CU329671 Genomic DNA. Translation: CAB51767.1.
PIRiT39700.
RefSeqiNP_595590.1. NM_001021486.2.

Genome annotation databases

EnsemblFungiiSPBC17A3.08.1; SPBC17A3.08.1:pep; SPBC17A3.08.
GeneIDi2539901.
KEGGispo:SPBC17A3.08.

Similar proteinsi

Entry informationi

Entry nameiYNF8_SCHPO
AccessioniPrimary (citable) accession number: Q9UUF1
Secondary accession number(s): O13630
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families