Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Deoxyribonuclease Tat-D

Gene

pi038

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has both endo- and exonuclease activities. Incises double-stranded DNA without obvious specificity via its endonuclease activity and excises the DNA from the 3'-to 5'-end by its exonuclease activity. May have a role in apoptosis (By similarity).By similarity

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi124 – 1241Divalent metal cation 1By similarity
Metal bindingi124 – 1241Divalent metal cation 2By similarity
Metal bindingi161 – 1611Divalent metal cation 2By similarity
Metal bindingi187 – 1871Divalent metal cation 2By similarity
Metal bindingi235 – 2351Divalent metal cation 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribonuclease Tat-D (EC:3.1.21.-)
Gene namesi
ORF Names:pi038, SPBC17A3.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC17A3.08.
PomBaseiSPBC17A3.08.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Deoxyribonuclease Tat-DPRO_0000317086Add
BLAST

Proteomic databases

MaxQBiQ9UUF1.

Interactioni

Protein-protein interaction databases

BioGridi276447. 5 interactions.
MINTiMINT-4712897.

Structurei

3D structure databases

ProteinModelPortaliQ9UUF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TatD-type hydrolase family.Curated

Phylogenomic databases

HOGENOMiHOG000201523.
InParanoidiQ9UUF1.
KOiK03424.
OMAiFDRLEFC.
OrthoDBiEOG7PZS7D.
PhylomeDBiQ9UUF1.

Family and domain databases

InterProiIPR032466. Metal_Hydrolase.
IPR001130. TatD_family.
[Graphical view]
PANTHERiPTHR10060. PTHR10060. 2 hits.
PfamiPF01026. TatD_DNase. 1 hit.
[Graphical view]
PIRSFiPIRSF005902. DNase_TatD. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UUF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASIRQAFVK SLRFYDIGYN ATDPVFRGIY HEKLKHPDDF DSIISRAKAV
60 70 80 90 100
GVEKMMITGD NVENSEEALN LATNYECFTS TVGVHPCQAQ CFLRHSEGPE
110 120 130 140 150
DYLVKLEALA NKGKASGKVV AFGEFGLDYD RLHYAPADVQ KMYFEEQLKV
160 170 180 190 200
AVRVQLPLFL HSRNAENDFF AILEKYLPEL PKKGVVHSFT GSIDEMRRCI
210 220 230 240 250
EHGLYVGVNG CSLKTEENLE VVRAIPLEKM LLETDAPWCE VRPSHAGHQF
260 270 280 290 300
LKTKLPFDSC KKERFKEGCM IRGRNEPCNT YIVAEIVAAL KDISLEELSE
310
QIWENSINLL SK
Length:312
Mass (Da):35,389
Last modified:May 1, 2000 - v1
Checksum:i6743BABB2BD5F409
GO

Sequence cautioni

The sequence BAA21418.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004537 Genomic DNA. Translation: BAA21418.1. Sequence problems.
CU329671 Genomic DNA. Translation: CAB51767.1.
PIRiT39700.
RefSeqiNP_595590.1. NM_001021486.2.

Genome annotation databases

EnsemblFungiiSPBC17A3.08.1; SPBC17A3.08.1:pep; SPBC17A3.08.
GeneIDi2539901.
KEGGispo:SPBC17A3.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004537 Genomic DNA. Translation: BAA21418.1. Sequence problems.
CU329671 Genomic DNA. Translation: CAB51767.1.
PIRiT39700.
RefSeqiNP_595590.1. NM_001021486.2.

3D structure databases

ProteinModelPortaliQ9UUF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276447. 5 interactions.
MINTiMINT-4712897.

Proteomic databases

MaxQBiQ9UUF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC17A3.08.1; SPBC17A3.08.1:pep; SPBC17A3.08.
GeneIDi2539901.
KEGGispo:SPBC17A3.08.

Organism-specific databases

EuPathDBiFungiDB:SPBC17A3.08.
PomBaseiSPBC17A3.08.

Phylogenomic databases

HOGENOMiHOG000201523.
InParanoidiQ9UUF1.
KOiK03424.
OMAiFDRLEFC.
OrthoDBiEOG7PZS7D.
PhylomeDBiQ9UUF1.

Miscellaneous databases

PROiQ9UUF1.

Family and domain databases

InterProiIPR032466. Metal_Hydrolase.
IPR001130. TatD_family.
[Graphical view]
PANTHERiPTHR10060. PTHR10060. 2 hits.
PfamiPF01026. TatD_DNase. 1 hit.
[Graphical view]
PIRSFiPIRSF005902. DNase_TatD. 1 hit.
SUPFAMiSSF51556. SSF51556. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A 38 kb segment containing the cdc2 gene from the left arm of fission yeast chromosome II: sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment."
    Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K., Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y., Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.
    Yeast 16:71-80(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYNF8_SCHPO
AccessioniPrimary (citable) accession number: Q9UUF1
Secondary accession number(s): O13630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.