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Protein

Peptidyl-prolyl cis-trans isomerase cyp6

Gene

cyp6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

  • regulation of phosphorylation of RNA polymerase II C-terminal domain Source: PomBase

Keywordsi

Molecular functionIsomerase, RNA-binding, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase cyp6 (EC:5.2.1.8)
Short name:
PPIase cyp6
Alternative name(s):
Rotamase cyp6
Gene namesi
Name:cyp6
ORF Names:SPBC17G9.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC17G9.05
PomBaseiSPBC17G9.05

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002329801 – 432Peptidyl-prolyl cis-trans isomerase cyp6Add BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UUE4
PaxDbiQ9UUE4
PRIDEiQ9UUE4

PTM databases

iPTMnetiQ9UUE4

Expressioni

Inductioni

Induced during the meiotic cycle.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi2764861 interactor.
STRINGi4896.SPBC17G9.05.1

Structurei

3D structure databases

ProteinModelPortaliQ9UUE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 168PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST168
Domaini244 – 322RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi325 – 432Arg-richAdd BLAST108

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000186284
InParanoidiQ9UUE4
KOiK12735
OMAiHSVQKNF
OrthoDBiEOG092C4XI2
PhylomeDBiQ9UUE4

Family and domain databases

CDDicd01921 cyclophilin_RRM, 1 hit
Gene3Di2.40.100.101 hit
3.30.70.3301 hit
InterProiView protein in InterPro
IPR035542 CRIP
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
IPR035538 Cyclophilin_PPIL4
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PTHR11071:SF156 PTHR11071:SF156, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF00076 RRM_1, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF50891 SSF50891, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UUE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLIETTVG DLVIDLFVKE APKTCENFLK LCKLKYYNFC PFYNIQHNYT
60 70 80 90 100
CQTGDPLGPT GDGGRCVWNV LNKGTRFFKA EFNPSLVHNK MGLVSMSTAT
110 120 130 140 150
ISSRDDKLLV CGSQFIITLS DNLEGLDERY PIYGQVAEGF DTLLKINDAI
160 170 180 190 200
CDEEGQPYRD IRIKHTIILD DPFEDPPDLV EPLRSPSPTP EQLATVRIGE
210 220 230 240 250
NEQIESETSE DKLQREKEME AEAEAVTLEM IGDLPFAHVA PPENVLFVCK
260 270 280 290 300
LNPVTQDEDL ELIFSRFGKI ISCQVIRDKE TGDSLQYAFI EFDNKESVEK
310 320 330 340 350
AYFKMQNVLI DDSRIHVDFS QSVARYRQYY NSNRDRKRSS SRSDDREYHR
360 370 380 390 400
RSDGRYDRSN YRDDYRHRRK ERDHRDDQSS FRNERFSNYY GDDRSYHKRR
410 420 430
NTGNKNCDDH LRDKSPERRY RYDRRYRDDR YR
Length:432
Mass (Da):50,776
Last modified:May 1, 2000 - v1
Checksum:i16FE19301626561C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB52803.1
PIRiT39728
RefSeqiNP_595894.1, NM_001021801.2

Genome annotation databases

EnsemblFungiiSPBC17G9.05.1; SPBC17G9.05.1:pep; SPBC17G9.05
GeneIDi2539942
KEGGispo:SPBC17G9.05

Similar proteinsi

Entry informationi

Entry nameiPPIL4_SCHPO
AccessioniPrimary (citable) accession number: Q9UUE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome