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Q9UUD6

- UBP11_SCHPO

UniProt

Q9UUD6 - UBP11_SCHPO

Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

ubp11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei59 – 591NucleophilePROSITE-ProRule annotation
    Active sitei302 – 3021Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein binding Source: PomBase
    2. ubiquitin-specific protease activity Source: PomBase

    GO - Biological processi

    1. protein deubiquitination Source: PomBase
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A63.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 11
    Ubiquitin thioesterase 11
    Ubiquitin-specific-processing protease 11
    Gene namesi
    Name:ubp11
    ORF Names:SPBC19C2.04c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC19C2.04c.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Ubiquitin carboxyl-terminal hydrolase 11PRO_0000080611Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    BioGridi277237. 23 interactions.
    MINTiMINT-4712261.
    STRINGi4896.SPBC19C2.04c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UUD6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 344296USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    OrthoDBiEOG7HB5JX.
    PhylomeDBiQ9UUD6.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UUD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTTPLSISR AKKYKTVFKG AAILTTFAAL YIVTSPSTGK RLVKNASIKG    50
    LYNVSGNDCF LNCVLQSLAS QESLLEILKL RCSSSTLYAT LYELLQKLNS 100
    GPGNPITPGS FLNSLEIATN KKLVRSIQQD AQEFLQHLVE TLELQKPHTY 150
    KWSKVLSFPV DSPFIGTMEQ KVQCCQCLAI SISYSTATSI QLCLPPEYSG 200
    NSNVSLLSLM EADREQHISD YKCDSCFKSS PKHSKTSCIR TVDWKNPPTI 250
    LQIQLERTSY TCQGLTRNNV SISFPSKLIL KNKHHYILRS LITHSGSVTY 300
    GHYLCYRLQD DIWWKANDSL ITKSSLNEAL SQTRSACLLF YEMESPLALD 350
    Length:350
    Mass (Da):39,169
    Last modified:May 1, 2000 - v1
    Checksum:i53986D30F9552DA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB52031.1.
    PIRiT39795.
    RefSeqiNP_595689.1. NM_001021586.2.

    Genome annotation databases

    EnsemblFungiiSPBC19C2.04c.1; SPBC19C2.04c.1:pep; SPBC19C2.04c.
    GeneIDi2540714.
    KEGGispo:SPBC19C2.04c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAB52031.1 .
    PIRi T39795.
    RefSeqi NP_595689.1. NM_001021586.2.

    3D structure databases

    ProteinModelPortali Q9UUD6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277237. 23 interactions.
    MINTi MINT-4712261.
    STRINGi 4896.SPBC19C2.04c-1.

    Protein family/group databases

    MEROPSi C19.A63.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC19C2.04c.1 ; SPBC19C2.04c.1:pep ; SPBC19C2.04c .
    GeneIDi 2540714.
    KEGGi spo:SPBC19C2.04c.

    Organism-specific databases

    PomBasei SPBC19C2.04c.

    Phylogenomic databases

    eggNOGi COG5077.
    OrthoDBi EOG7HB5JX.
    PhylomeDBi Q9UUD6.

    Miscellaneous databases

    NextBioi 20801836.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiUBP11_SCHPO
    AccessioniPrimary (citable) accession number: Q9UUD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3