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Protein

Cytoplasmic tRNA 2-thiolation protein 2

Gene

ctu2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm5 tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.UniRule annotation1 Publication

Pathwayi: 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis

This protein is involved in the pathway 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

  • protein urmylation Source: PomBase
  • tRNA wobble position uridine thiolation Source: PomBase

Keywordsi

Biological processtRNA processing

Enzyme and pathway databases

UniPathwayiUPA00988

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic tRNA 2-thiolation protein 2UniRule annotation
Gene namesi
Name:ctu2
Synonyms:ncs2
ORF Names:SPBC19C2.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPBC19C2.13c
PomBaseiSPBC19C2.13c ctu2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003594081 – 366Cytoplasmic tRNA 2-thiolation protein 2Add BLAST366

Proteomic databases

MaxQBiQ9UUC7
PaxDbiQ9UUC7
PRIDEiQ9UUC7

Interactioni

Subunit structurei

Interacts with ctu1.1 Publication

Protein-protein interaction databases

BioGridi277412, 24 interactors
DIPiDIP-29901N
IntActiQ9UUC7, 1 interactor
STRINGi4896.SPBC19C2.13c.1

Structurei

3D structure databases

ProteinModelPortaliQ9UUC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CTU2/NCS2 family.UniRule annotation

Phylogenomic databases

InParanoidiQ9UUC7
KOiK14169
OMAiMCSIGED
OrthoDBiEOG092C3DSC
PhylomeDBiQ9UUC7

Family and domain databases

Gene3Di3.40.50.620, 1 hit
HAMAPiMF_03054 CTU2, 1 hit
InterProiView protein in InterPro
IPR019407 CTU2
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR20882 PTHR20882, 1 hit
PfamiView protein in Pfam
PF10288 CTU2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UUC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNTALDNSA DSKCSKCDNK ATVLTKSDAV CDSCFVRRIE NKIRRQFELV
60 70 80 90 100
RPNLQGRKSK RAMLAISGGI SSMAMLETAN YLSKYRDDNY RPMFDELLAV
110 120 130 140 150
HFQWGTDSAV AKTIEESISK NYPKCPFKVI GEAELLNRTI ATDSRGNIEI
160 170 180 190 200
NADNEKFNPE VISSLASRQD LLYRIRDKLL VSYARKANCD TIVFGDSGTT
210 220 230 240 250
IAARVLELVA EGRGFAIPWY TSVCSKLPNC DTFLLRPLRE VLSSDLKSYM
260 270 280 290 300
NIKGLAFCDS LIEARPNTIH GVTESYFSSL NDTFPSLVST VVKMSSKLHV
310 320 330 340 350
PSTEAICTIC NLPMQEDAET WLQKTTVEHP DSVEGIKNQN VCYGCSVSLK
360
SLKGTLHIPD IEKEGI
Length:366
Mass (Da):40,742
Last modified:May 1, 2000 - v1
Checksum:i7D59F90208A79E09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB52040.1
PIRiT39804
RefSeqiNP_595698.1, NM_001021595.2

Genome annotation databases

EnsemblFungiiSPBC19C2.13c.1; SPBC19C2.13c.1:pep; SPBC19C2.13c
GeneIDi2540896
KEGGispo:SPBC19C2.13c

Entry informationi

Entry nameiCTU2_SCHPO
AccessioniPrimary (citable) accession number: Q9UUC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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