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Q9UUB6

- UBLH2_SCHPO

UniProt

Q9UUB6 - UBLH2_SCHPO

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Protein

Ubiquitin carboxyl-terminal hydrolase 2

Gene

uch2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831NucleophileBy similarity
Active sitei159 – 1591Proton donorBy similarity
Sitei174 – 1741Important for enzyme activityBy similarity

GO - Molecular functioni

  1. omega peptidase activity Source: InterPro
  2. ubiquitin-specific protease activity Source: PomBase

GO - Biological processi

  1. proteasome-mediated ubiquitin-dependent protein catabolic process Source: PomBase
  2. protein deubiquitination Source: PomBase
  3. protein deubiquitination involved in ubiquitin-dependent protein catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 2 (EC:3.4.19.12)
Gene namesi
Name:uch2
ORF Names:SPBC409.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC409.06.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. nuclear periphery Source: PomBase
  2. nucleus Source: PomBase
  3. proteasome complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Ubiquitin carboxyl-terminal hydrolase 2PRO_0000234561Add
BLAST

Proteomic databases

MaxQBiQ9UUB6.
PaxDbiQ9UUB6.

Interactioni

Subunit structurei

Component of the 26S proteasome. Interacts with rpn10.1 Publication

Protein-protein interaction databases

BioGridi277472. 63 interactions.
IntActiQ9UUB6. 1 interaction.
MINTiMINT-4711794.
STRINGi4896.SPBC409.06-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UUB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family.Curated

Phylogenomic databases

eggNOGiNOG321645.
HOGENOMiHOG000203918.
InParanoidiQ9UUB6.
KOiK05610.
OMAiERWAFEN.
OrthoDBiEOG7FBRWB.
PhylomeDBiQ9UUB6.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
IPR017390. Ubiquitinyl_hydrolase_UCH37.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PIRSFiPIRSF038120. Ubiquitinyl_hydrolase_UCH37. 1 hit.
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

Q9UUB6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWTTIESDA GVFTDLIENL GVKDVEVDEL YSLDVDSLRQ FPDIYGIIFL
60 70 80 90 100
FKWNSKVDKP DGTMDYDSMD NIFFAKQVIN NACATQALLS VLLNHSDEID
110 120 130 140 150
LGTTLSEFKD FSKTLPPELK GEALGNSEHI RCCHNSFARS DPFISEEVRA
160 170 180 190 200
ATDEDEVYHF IAYTNINNVF YELDGLQAAP INHGSCTKEE FAEKAVSVIQ
210 220 230 240 250
ARIANYDPAE IRFNLMVICK DKKASLLTRE DLTDEEKAAS IAVEDEKRLR
260 270 280 290 300
WKRENQLRRH NFVGLFVELS KLLVKDRIDK NTWNSTLETA KAKYASQKRP
Length:300
Mass (Da):34,196
Last modified:May 1, 2000 - v1
Checksum:i93B13076EF2EDB80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB52608.1.
PIRiT40434.
RefSeqiNP_595456.1. NM_001021366.2.

Genome annotation databases

EnsemblFungiiSPBC409.06.1; SPBC409.06.1:pep; SPBC409.06.
GeneIDi2540956.
KEGGispo:SPBC409.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB52608.1 .
PIRi T40434.
RefSeqi NP_595456.1. NM_001021366.2.

3D structure databases

ProteinModelPortali Q9UUB6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277472. 63 interactions.
IntActi Q9UUB6. 1 interaction.
MINTi MINT-4711794.
STRINGi 4896.SPBC409.06-1.

Protein family/group databases

MEROPSi C12.009.

Proteomic databases

MaxQBi Q9UUB6.
PaxDbi Q9UUB6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC409.06.1 ; SPBC409.06.1:pep ; SPBC409.06 .
GeneIDi 2540956.
KEGGi spo:SPBC409.06.

Organism-specific databases

PomBasei SPBC409.06.

Phylogenomic databases

eggNOGi NOG321645.
HOGENOMi HOG000203918.
InParanoidi Q9UUB6.
KOi K05610.
OMAi ERWAFEN.
OrthoDBi EOG7FBRWB.
PhylomeDBi Q9UUB6.

Miscellaneous databases

NextBioi 20802071.
PROi Q9UUB6.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
IPR017390. Ubiquitinyl_hydrolase_UCH37.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PIRSFi PIRSF038120. Ubiquitinyl_hydrolase_UCH37. 1 hit.
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast."
    Stone M., Hartmann-Petersen R., Seeger M., Bech-Otschir D., Wallace M., Gordon C.
    J. Mol. Biol. 344:697-706(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RPN10, SUBCELLULAR LOCATION.
  3. "Identification of a 26S proteasome-associated UCH in fission yeast."
    Li T., Naqvi N.I., Yang H., Teo T.S.
    Biochem. Biophys. Res. Commun. 272:270-275(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiUBLH2_SCHPO
AccessioniPrimary (citable) accession number: Q9UUB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3