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Protein

Kinetochore protein mis13

Gene

mis13

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct segregation of chromosomes and for maintaining the inner centromere structure.

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • meiotic cell cycle Source: UniProtKB-KW
  • mitotic sister chromatid segregation Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Meiosis, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore protein mis13
Alternative name(s):
NMS complex subunit mis13
Gene namesi
Name:mis13
Synonyms:cnl1, cnl3
ORF Names:SPBC409.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC409.09c.
PomBaseiSPBC409.09c. mis13.

Subcellular locationi

GO - Cellular componenti

  • condensed chromosome, centromeric region Source: PomBase
  • condensed nuclear chromosome inner kinetochore Source: PomBase
  • MIS12/MIND type complex Source: InterPro
  • NMS complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Kinetochore protein mis13PRO_0000290643Add
BLAST

Proteomic databases

MaxQBiQ9UUB5.

Interactioni

Subunit structurei

Component of the NMS super complex which consists of mis12, mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25. Interacts with dis1, mal2, mis14, ppe1 and ekc1.2 Publications

Protein-protein interaction databases

BioGridi277562. 7 interactions.
IntActiQ9UUB5. 1 interaction.
MINTiMINT-4711744.

Family & Domainsi

Phylogenomic databases

InParanoidiQ9UUB5.
KOiK11560.
OrthoDBiEOG7Q5HPC.
PhylomeDBiQ9UUB5.

Family and domain databases

InterProiIPR013218. Dsn1/Mis13.
[Graphical view]
PfamiPF08202. MIS13. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UUB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKPEEQEG FVFVRKGKEK AGSKRRKSSV EDDPDTSQTD GLVELPVSDT
60 70 80 90 100
PIVKRNKELR KGKGRRSSLD QRGKRASSIG TGFEALPHAD VPSHEYYRHI
110 120 130 140 150
SKDLSEPLRI KQLLLWASSK ALEEQRKKYG ETEEASEAAI ARSIVQEVLN
160 170 180 190 200
ELLANKVSVS WYQRPPDAVI PNKPHPQNLK NAQLVDELSA KLTQLHNEEA
210 220 230 240 250
AWRAVAANSV SSDKSILSFK KAVESIDSKQ DLDKQDSPLP PDDAPELPNI
260 270 280 290 300
SKLKPKFHTL LDMLAENIHT LHSLTNAGPE VRSSYGRLAA QDFIAHRKSL
310 320
LSFSKYVDTM NLLRLLSEAS YKSSSNESV
Length:329
Mass (Da):36,798
Last modified:May 1, 2000 - v1
Checksum:i7A85BDC557C8C04D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB52611.1.
PIRiT40436.
RefSeqiNP_595459.1. NM_001021369.2.

Genome annotation databases

EnsemblFungiiSPBC409.09c.1; SPBC409.09c.1:pep; SPBC409.09c.
GeneIDi2541047.
KEGGispo:SPBC409.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB52611.1.
PIRiT40436.
RefSeqiNP_595459.1. NM_001021369.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277562. 7 interactions.
IntActiQ9UUB5. 1 interaction.
MINTiMINT-4711744.

Proteomic databases

MaxQBiQ9UUB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC409.09c.1; SPBC409.09c.1:pep; SPBC409.09c.
GeneIDi2541047.
KEGGispo:SPBC409.09c.

Organism-specific databases

EuPathDBiFungiDB:SPBC409.09c.
PomBaseiSPBC409.09c. mis13.

Phylogenomic databases

InParanoidiQ9UUB5.
KOiK11560.
OrthoDBiEOG7Q5HPC.
PhylomeDBiQ9UUB5.

Miscellaneous databases

PROiQ9UUB5.

Family and domain databases

InterProiIPR013218. Dsn1/Mis13.
[Graphical view]
PfamiPF08202. MIS13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Molecular analysis of kinetochore architecture in fission yeast."
    Liu X., McLeod I., Anderson S., Yates J.R. III, He X.
    EMBO J. 24:2919-2930(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NMS COMPLEX.
  3. "Reconstruction of the kinetochore during meiosis in fission yeast Schizosaccharomyces pombe."
    Hayashi A., Asakawa H., Haraguchi T., Hiraoka Y.
    Mol. Biol. Cell 17:5173-5184(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NMS COMPLEX.
  4. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMIS13_SCHPO
AccessioniPrimary (citable) accession number: Q9UUB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.