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Protein

Kinetochore protein mis13

Gene

mis13

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct segregation of chromosomes and for maintaining the inner centromere structure.

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore protein mis13
Alternative name(s):
NMS complex subunit mis13
Gene namesi
Name:mis13
Synonyms:cnl1, cnl3
ORF Names:SPBC409.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC409.09c
PomBaseiSPBC409.09c mis13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002906431 – 329Kinetochore protein mis13Add BLAST329

Proteomic databases

MaxQBiQ9UUB5
PaxDbiQ9UUB5
PRIDEiQ9UUB5

Interactioni

Subunit structurei

Component of the NMS super complex which consists of mis12, mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25. Interacts with dis1, mal2, mis14, ppe1 and ekc1.2 Publications

Protein-protein interaction databases

BioGridi277562, 7 interactors
IntActiQ9UUB5, 1 interactor
STRINGi4896.SPBC409.09c.1

Family & Domainsi

Phylogenomic databases

InParanoidiQ9UUB5
KOiK11560
OrthoDBiEOG092C2LDT
PhylomeDBiQ9UUB5

Family and domain databases

InterProiView protein in InterPro
IPR013218 Dsn1/Mis13
PANTHERiPTHR14778 PTHR14778, 1 hit
PfamiView protein in Pfam
PF08202 MIS13, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UUB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKPEEQEG FVFVRKGKEK AGSKRRKSSV EDDPDTSQTD GLVELPVSDT
60 70 80 90 100
PIVKRNKELR KGKGRRSSLD QRGKRASSIG TGFEALPHAD VPSHEYYRHI
110 120 130 140 150
SKDLSEPLRI KQLLLWASSK ALEEQRKKYG ETEEASEAAI ARSIVQEVLN
160 170 180 190 200
ELLANKVSVS WYQRPPDAVI PNKPHPQNLK NAQLVDELSA KLTQLHNEEA
210 220 230 240 250
AWRAVAANSV SSDKSILSFK KAVESIDSKQ DLDKQDSPLP PDDAPELPNI
260 270 280 290 300
SKLKPKFHTL LDMLAENIHT LHSLTNAGPE VRSSYGRLAA QDFIAHRKSL
310 320
LSFSKYVDTM NLLRLLSEAS YKSSSNESV
Length:329
Mass (Da):36,798
Last modified:May 1, 2000 - v1
Checksum:i7A85BDC557C8C04D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB52611.1
PIRiT40436
RefSeqiNP_595459.1, NM_001021369.2

Genome annotation databases

EnsemblFungiiSPBC409.09c.1; SPBC409.09c.1:pep; SPBC409.09c
GeneIDi2541047
KEGGispo:SPBC409.09c

Similar proteinsi

Entry informationi

Entry nameiMIS13_SCHPO
AccessioniPrimary (citable) accession number: Q9UUB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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