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Protein

Adenylate kinase isoenzyme 6 homolog

Gene

SPCC830.11c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44AMPUniRule annotation1
Binding sitei84ATPUniRule annotation1
Binding sitei110ATPUniRule annotation1
Binding sitei114ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 23ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6 homologUniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Dual activity adenylate kinase/ATPaseUniRule annotation
Short name:
AK/ATPaseUniRule annotation
Gene namesi
ORF Names:SPCC830.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC830.11c.
PomBaseiSPCC830.11c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003633671 – 175Adenylate kinase isoenzyme 6 homologAdd BLAST175

Proteomic databases

MaxQBiQ9UU88.
PRIDEiQ9UU88.

Interactioni

Protein-protein interaction databases

BioGridi275335. 4 interactors.
MINTiMINT-4711398.

Structurei

3D structure databases

ProteinModelPortaliQ9UU88.
SMRiQ9UU88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 61NMPbindUniRule annotationAdd BLAST24
Regioni113 – 123LIDUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000224472.
InParanoidiQ9UU88.
KOiK18532.
OMAiQSWIVDE.
OrthoDBiEOG092C5GXJ.
PhylomeDBiQ9UU88.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6. 1 hit.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UU88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNEERELPN IIICGTPGTG KTTLAEQVAE TTELENICIG DVVKENHLHF
60 70 80 90 100
GFDEKWKTYD VDEDKVLDYL EPKLLKGGCI IDWHTCGLFS EELIDLVVVL
110 120 130 140 150
RTDHSKLWER LESRGYSLEK IQENNEAEIM QICLEEARES FDPKIVVELP
160 170
SESIEEMESN LSRITQWVTN WKKNH
Length:175
Mass (Da):20,222
Last modified:May 1, 2000 - v1
Checksum:iD849800ECE47FD1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB52884.1.
PIRiT41637.
RefSeqiNP_588481.1. NM_001023472.2.

Genome annotation databases

EnsemblFungiiSPCC830.11c.1; SPCC830.11c.1:pep; SPCC830.11c.
GeneIDi2538752.
KEGGispo:SPCC830.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAB52884.1.
PIRiT41637.
RefSeqiNP_588481.1. NM_001023472.2.

3D structure databases

ProteinModelPortaliQ9UU88.
SMRiQ9UU88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275335. 4 interactors.
MINTiMINT-4711398.

Proteomic databases

MaxQBiQ9UU88.
PRIDEiQ9UU88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC830.11c.1; SPCC830.11c.1:pep; SPCC830.11c.
GeneIDi2538752.
KEGGispo:SPCC830.11c.

Organism-specific databases

EuPathDBiFungiDB:SPCC830.11c.
PomBaseiSPCC830.11c.

Phylogenomic databases

HOGENOMiHOG000224472.
InParanoidiQ9UU88.
KOiK18532.
OMAiQSWIVDE.
OrthoDBiEOG092C5GXJ.
PhylomeDBiQ9UU88.

Enzyme and pathway databases

ReactomeiR-SPO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

PROiQ9UU88.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6. 1 hit.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKAD6_SCHPO
AccessioniPrimary (citable) accession number: Q9UU88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.