Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin carboxyl-terminal hydrolase 21

Gene

ubp21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in regulating the steady-state levels of proteins including prp4.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei239NucleophilePROSITE-ProRule annotation1
Active sitei481Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • endopeptidase activity Source: PomBase
  • thiol-dependent ubiquitin-specific protease activity Source: PomBase
  • thiol-dependent ubiquitinyl hydrolase activity Source: PomBase
  • ubiquitinyl hydrolase activity Source: PomBase

GO - Biological processi

  • negative regulation of error-prone translesion synthesis Source: PomBase
  • protein deubiquitination Source: PomBase
  • protein K11-linked deubiquitination Source: PomBase
  • protein K63-linked deubiquitination Source: PomBase
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-6781823 Formation of TC-NER Pre-Incision Complex
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Protein family/group databases

MEROPSiC19.A59

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 21 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 21
Ubiquitin thioesterase 21
Ubiquitin-specific-processing protease 21
Gene namesi
Name:ubp21
Synonyms:ubp15, ubpd
ORF Names:SPBC713.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC713.02c
PomBaseiSPBC713.02c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806141 – 1129Ubiquitin carboxyl-terminal hydrolase 21Add BLAST1129

Proteomic databases

MaxQBiQ9UTT1
PaxDbiQ9UTT1
PRIDEiQ9UTT1

PTM databases

iPTMnetiQ9UTT1

Interactioni

Protein-protein interaction databases

BioGridi277646, 6 interactors
IntActiQ9UTT1, 1 interactor
STRINGi4896.SPBC713.02c.1

Structurei

3D structure databases

ProteinModelPortaliQ9UTT1
SMRiQ9UTT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 204MATHPROSITE-ProRule annotationAdd BLAST154
Domaini230 – 545USPAdd BLAST316

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

HOGENOMiHOG000160240
InParanoidiQ9UTT1
KOiK11838
OMAiPDKEWEN
OrthoDBiEOG092C06CQ
PhylomeDBiQ9UTT1

Family and domain databases

Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR001394 Peptidase_C19_UCH
IPR008974 TRAF-like
IPR024729 USP7_ICP0-binding_dom
IPR029346 USP_C
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00917 MATH, 1 hit
PF00443 UCH, 1 hit
PF14533 USP7_C2, 1 hit
PF12436 USP7_ICP0_bdg, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 2 hits
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UTT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSNVDAEE VNMDSSMELE ESSQEPLRAD NYEEIYNSLV HHEPDLEEAA
60 70 80 90 100
HASYSWVVKN FSTLEDKTYS PLFKAGHTTW RIVLFPKGCN QTEYASVFLE
110 120 130 140 150
YLPQCKVEAI RKYEAELAAG KTPTIDPEIV NDETYSCCAQ FALSLSNVQD
160 170 180 190 200
PTVMQINTSH HRFRSEVKDW GFTRFVDLRK IAVPTPEFPV PFLENDEICI
210 220 230 240 250
SVTVRVLQDP TGVLWHSFVN YNSKKETGYV GLKNQGATCY MNSLLQSLFF
260 270 280 290 300
TNIFRKTVYK IPTDNDDSRD SVAYALQRVF YNLEKQREPV STTELTRSFG
310 320 330 340 350
WNSFDSFMQH DIQEFNRVLQ DNLEKKMKGT EVENALNDIF VGKMKSYVKC
360 370 380 390 400
IDVNYESSRV EDFWDIQLNV KGMDTLEDSF RDAIQVETLT GDNKYYAEGH
410 420 430 440 450
GLQDAHKGII FESLPNVLQL QLKRFDYDML RDMMVKINDR HEFPLEIDLE
460 470 480 490 500
PYLSETADKS ESHVYVLHGV LVHGGDLHGG HYYALIKPEK DSNWFKFDDD
510 520 530 540 550
RVTRATIKEV LEDNYGGEPA GRAKGYNGNP FKRFMNAYML VYFRKSRLDH
560 570 580 590 600
ILSPVTAEDV PFHVRNTLDE EHRVVERKLL EREEQQIYRR VRVLTTDGFK
610 620 630 640 650
KYHGFDMTDF SASDDDPVLI TTKIKRNANI WDLQKHLAGL LNRDTSGIRI
660 670 680 690 700
WLMTNRQNRT VRVDLPLDKK TILVDQICDM HIRKDMDMRV YVEFLSEHNQ
710 720 730 740 750
LLADFGATDD NDFDTYIFLK IFDYETQQIS GLADLHVSKN SPISSLSEWI
760 770 780 790 800
REHLKWSSDV PITYYEEIKT GMVDVLDPNA SFEKSEIQVG DIICFEKKLV
810 820 830 840 850
HDSSSDTSHP YKSALDLYDF MAHRVVITFE PRYSDDTNNG VFDLVLTTHT
860 870 880 890 900
NYTDMARAVA NKLNVDPNYL QFTMAHLPSR TPRSVIRNPS KFTLQNAIPS
910 920 930 940 950
TYSHNQNVVM FYEVLDITLS ELERKQLIRV HFLSNGISHE TQMEFYVDKE
960 970 980 990 1000
GTVEDILRQV TQKVPLNAED ASRLRLYEVY NHRILKSHLP TDGIYDLNEF
1010 1020 1030 1040 1050
STAYVEVTPK EEQMQLKTDD AVSIVVQHFF KDLSRLHDIP FYFVLLRGET
1060 1070 1080 1090 1100
LKDLKKRLQK RLGYNDTQFS KVKLAVLQAQ SFGKPYYLTD DDEVLYGELE
1110 1120
PQSHILGLDH PPANGSAQYH GMDQAIRMK
Length:1,129
Mass (Da):130,832
Last modified:August 14, 2001 - v2
Checksum:i536681DD9E78EBF8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42H → D in AAF01440 (PubMed:11919719).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187961 Genomic DNA Translation: AAF01440.1
CU329671 Genomic DNA Translation: CAC22603.1
RefSeqiNP_595341.1, NM_001021249.2

Genome annotation databases

EnsemblFungiiSPBC713.02c.1; SPBC713.02c.1:pep; SPBC713.02c
GeneIDi2541131
KEGGispo:SPBC713.02c

Entry informationi

Entry nameiUBP21_SCHPO
AccessioniPrimary (citable) accession number: Q9UTT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health