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Q9UTT1

- UBP21_SCHPO

UniProt

Q9UTT1 - UBP21_SCHPO

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Protein

Ubiquitin carboxyl-terminal hydrolase 21

Gene

ubp21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Involved in regulating the steady-state levels of proteins including prp4.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei239 – 2391NucleophilePROSITE-ProRule annotation
Active sitei481 – 4811Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: PomBase

GO - Biological processi

  1. endocytosis Source: PomBase
  2. protein deubiquitination Source: PomBase
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.A59.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 21 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 21
Ubiquitin thioesterase 21
Ubiquitin-specific-processing protease 21
Gene namesi
Name:ubp21
Synonyms:ubp15, ubpd
ORF Names:SPBC713.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC713.02c.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cell division site Source: PomBase
  2. cytoplasm Source: PomBase
  3. cytosol Source: PomBase
  4. nucleus Source: PomBase
  5. transport vesicle Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11291129Ubiquitin carboxyl-terminal hydrolase 21PRO_0000080614Add
BLAST

Proteomic databases

MaxQBiQ9UTT1.

Interactioni

Protein-protein interaction databases

BioGridi277646. 4 interactions.
IntActiQ9UTT1. 1 interaction.
MINTiMINT-4711257.
STRINGi4896.SPBC713.02c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UTT1.
SMRiQ9UTT1. Positions 224-575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 204154MATHPROSITE-ProRule annotationAdd
BLAST
Domaini230 – 545316USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 MATH domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000160240.
InParanoidiQ9UTT1.
KOiK11838.
OMAiYKLQDAN.
OrthoDBiEOG7C2R8P.
PhylomeDBiQ9UTT1.

Family and domain databases

InterProiIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 2 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UTT1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLSNVDAEE VNMDSSMELE ESSQEPLRAD NYEEIYNSLV HHEPDLEEAA
60 70 80 90 100
HASYSWVVKN FSTLEDKTYS PLFKAGHTTW RIVLFPKGCN QTEYASVFLE
110 120 130 140 150
YLPQCKVEAI RKYEAELAAG KTPTIDPEIV NDETYSCCAQ FALSLSNVQD
160 170 180 190 200
PTVMQINTSH HRFRSEVKDW GFTRFVDLRK IAVPTPEFPV PFLENDEICI
210 220 230 240 250
SVTVRVLQDP TGVLWHSFVN YNSKKETGYV GLKNQGATCY MNSLLQSLFF
260 270 280 290 300
TNIFRKTVYK IPTDNDDSRD SVAYALQRVF YNLEKQREPV STTELTRSFG
310 320 330 340 350
WNSFDSFMQH DIQEFNRVLQ DNLEKKMKGT EVENALNDIF VGKMKSYVKC
360 370 380 390 400
IDVNYESSRV EDFWDIQLNV KGMDTLEDSF RDAIQVETLT GDNKYYAEGH
410 420 430 440 450
GLQDAHKGII FESLPNVLQL QLKRFDYDML RDMMVKINDR HEFPLEIDLE
460 470 480 490 500
PYLSETADKS ESHVYVLHGV LVHGGDLHGG HYYALIKPEK DSNWFKFDDD
510 520 530 540 550
RVTRATIKEV LEDNYGGEPA GRAKGYNGNP FKRFMNAYML VYFRKSRLDH
560 570 580 590 600
ILSPVTAEDV PFHVRNTLDE EHRVVERKLL EREEQQIYRR VRVLTTDGFK
610 620 630 640 650
KYHGFDMTDF SASDDDPVLI TTKIKRNANI WDLQKHLAGL LNRDTSGIRI
660 670 680 690 700
WLMTNRQNRT VRVDLPLDKK TILVDQICDM HIRKDMDMRV YVEFLSEHNQ
710 720 730 740 750
LLADFGATDD NDFDTYIFLK IFDYETQQIS GLADLHVSKN SPISSLSEWI
760 770 780 790 800
REHLKWSSDV PITYYEEIKT GMVDVLDPNA SFEKSEIQVG DIICFEKKLV
810 820 830 840 850
HDSSSDTSHP YKSALDLYDF MAHRVVITFE PRYSDDTNNG VFDLVLTTHT
860 870 880 890 900
NYTDMARAVA NKLNVDPNYL QFTMAHLPSR TPRSVIRNPS KFTLQNAIPS
910 920 930 940 950
TYSHNQNVVM FYEVLDITLS ELERKQLIRV HFLSNGISHE TQMEFYVDKE
960 970 980 990 1000
GTVEDILRQV TQKVPLNAED ASRLRLYEVY NHRILKSHLP TDGIYDLNEF
1010 1020 1030 1040 1050
STAYVEVTPK EEQMQLKTDD AVSIVVQHFF KDLSRLHDIP FYFVLLRGET
1060 1070 1080 1090 1100
LKDLKKRLQK RLGYNDTQFS KVKLAVLQAQ SFGKPYYLTD DDEVLYGELE
1110 1120
PQSHILGLDH PPANGSAQYH GMDQAIRMK
Length:1,129
Mass (Da):130,832
Last modified:August 14, 2001 - v2
Checksum:i536681DD9E78EBF8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421H → D in AAF01440. (PubMed:11919719)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187961 Genomic DNA. Translation: AAF01440.1.
CU329671 Genomic DNA. Translation: CAC22603.1.
RefSeqiNP_595341.1. NM_001021249.2.

Genome annotation databases

EnsemblFungiiSPBC713.02c.1; SPBC713.02c.1:pep; SPBC713.02c.
GeneIDi2541131.
KEGGispo:SPBC713.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187961 Genomic DNA. Translation: AAF01440.1 .
CU329671 Genomic DNA. Translation: CAC22603.1 .
RefSeqi NP_595341.1. NM_001021249.2.

3D structure databases

ProteinModelPortali Q9UTT1.
SMRi Q9UTT1. Positions 224-575.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277646. 4 interactions.
IntActi Q9UTT1. 1 interaction.
MINTi MINT-4711257.
STRINGi 4896.SPBC713.02c-1.

Protein family/group databases

MEROPSi C19.A59.

Proteomic databases

MaxQBi Q9UTT1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC713.02c.1 ; SPBC713.02c.1:pep ; SPBC713.02c .
GeneIDi 2541131.
KEGGi spo:SPBC713.02c.

Organism-specific databases

PomBasei SPBC713.02c.

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000160240.
InParanoidi Q9UTT1.
KOi K11838.
OMAi YKLQDAN.
OrthoDBi EOG7C2R8P.
PhylomeDBi Q9UTT1.

Miscellaneous databases

NextBioi 20802244.
PROi Q9UTT1.

Family and domain databases

InterProi IPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view ]
Pfami PF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view ]
SMARTi SM00061. MATH. 1 hit.
[Graphical view ]
SUPFAMi SSF49599. SSF49599. 2 hits.
PROSITEi PS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The deubiquitinating enzyme Ubp21p of fission yeast stabilizes a mutant form of protein kinase Prp4p."
    Richert K., Schmidt H., Gross T., Kaeufer N.F.
    Mol. Genet. Genomics 267:88-95(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiUBP21_SCHPO
AccessioniPrimary (citable) accession number: Q9UTT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3