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Q9UTT1

- UBP21_SCHPO

UniProt

Q9UTT1 - UBP21_SCHPO

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Protein

Ubiquitin carboxyl-terminal hydrolase 21

Gene
ubp21, ubp15, ubpd, SPBC713.02c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Involved in regulating the steady-state levels of proteins including prp4.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei239 – 2391Nucleophile By similarity
Active sitei481 – 4811Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: PomBase

GO - Biological processi

  1. endocytosis Source: PomBase
  2. protein deubiquitination Source: PomBase
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.A59.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 21 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 21
Ubiquitin thioesterase 21
Ubiquitin-specific-processing protease 21
Gene namesi
Name:ubp21
Synonyms:ubp15, ubpd
ORF Names:SPBC713.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC713.02c.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cell division site Source: PomBase
  2. cytoplasm Source: PomBase
  3. cytosol Source: PomBase
  4. nucleus Source: PomBase
  5. transport vesicle Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11291129Ubiquitin carboxyl-terminal hydrolase 21PRO_0000080614Add
BLAST

Proteomic databases

MaxQBiQ9UTT1.

Interactioni

Protein-protein interaction databases

BioGridi277646. 4 interactions.
IntActiQ9UTT1. 1 interaction.
MINTiMINT-4711257.
STRINGi4896.SPBC713.02c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UTT1.
SMRiQ9UTT1. Positions 224-575.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 204154MATHAdd
BLAST
Domaini230 – 545316USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 MATH domain.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000160240.
KOiK11838.
OMAiYKLQDAN.
OrthoDBiEOG7C2R8P.
PhylomeDBiQ9UTT1.

Family and domain databases

InterProiIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 2 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UTT1-1 [UniParc]FASTAAdd to Basket

« Hide

MVLSNVDAEE VNMDSSMELE ESSQEPLRAD NYEEIYNSLV HHEPDLEEAA     50
HASYSWVVKN FSTLEDKTYS PLFKAGHTTW RIVLFPKGCN QTEYASVFLE 100
YLPQCKVEAI RKYEAELAAG KTPTIDPEIV NDETYSCCAQ FALSLSNVQD 150
PTVMQINTSH HRFRSEVKDW GFTRFVDLRK IAVPTPEFPV PFLENDEICI 200
SVTVRVLQDP TGVLWHSFVN YNSKKETGYV GLKNQGATCY MNSLLQSLFF 250
TNIFRKTVYK IPTDNDDSRD SVAYALQRVF YNLEKQREPV STTELTRSFG 300
WNSFDSFMQH DIQEFNRVLQ DNLEKKMKGT EVENALNDIF VGKMKSYVKC 350
IDVNYESSRV EDFWDIQLNV KGMDTLEDSF RDAIQVETLT GDNKYYAEGH 400
GLQDAHKGII FESLPNVLQL QLKRFDYDML RDMMVKINDR HEFPLEIDLE 450
PYLSETADKS ESHVYVLHGV LVHGGDLHGG HYYALIKPEK DSNWFKFDDD 500
RVTRATIKEV LEDNYGGEPA GRAKGYNGNP FKRFMNAYML VYFRKSRLDH 550
ILSPVTAEDV PFHVRNTLDE EHRVVERKLL EREEQQIYRR VRVLTTDGFK 600
KYHGFDMTDF SASDDDPVLI TTKIKRNANI WDLQKHLAGL LNRDTSGIRI 650
WLMTNRQNRT VRVDLPLDKK TILVDQICDM HIRKDMDMRV YVEFLSEHNQ 700
LLADFGATDD NDFDTYIFLK IFDYETQQIS GLADLHVSKN SPISSLSEWI 750
REHLKWSSDV PITYYEEIKT GMVDVLDPNA SFEKSEIQVG DIICFEKKLV 800
HDSSSDTSHP YKSALDLYDF MAHRVVITFE PRYSDDTNNG VFDLVLTTHT 850
NYTDMARAVA NKLNVDPNYL QFTMAHLPSR TPRSVIRNPS KFTLQNAIPS 900
TYSHNQNVVM FYEVLDITLS ELERKQLIRV HFLSNGISHE TQMEFYVDKE 950
GTVEDILRQV TQKVPLNAED ASRLRLYEVY NHRILKSHLP TDGIYDLNEF 1000
STAYVEVTPK EEQMQLKTDD AVSIVVQHFF KDLSRLHDIP FYFVLLRGET 1050
LKDLKKRLQK RLGYNDTQFS KVKLAVLQAQ SFGKPYYLTD DDEVLYGELE 1100
PQSHILGLDH PPANGSAQYH GMDQAIRMK 1129
Length:1,129
Mass (Da):130,832
Last modified:August 14, 2001 - v2
Checksum:i536681DD9E78EBF8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421H → D in AAF01440. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF187961 Genomic DNA. Translation: AAF01440.1.
CU329671 Genomic DNA. Translation: CAC22603.1.
RefSeqiNP_595341.1. NM_001021249.2.

Genome annotation databases

EnsemblFungiiSPBC713.02c.1; SPBC713.02c.1:pep; SPBC713.02c.
GeneIDi2541131.
KEGGispo:SPBC713.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF187961 Genomic DNA. Translation: AAF01440.1 .
CU329671 Genomic DNA. Translation: CAC22603.1 .
RefSeqi NP_595341.1. NM_001021249.2.

3D structure databases

ProteinModelPortali Q9UTT1.
SMRi Q9UTT1. Positions 224-575.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277646. 4 interactions.
IntActi Q9UTT1. 1 interaction.
MINTi MINT-4711257.
STRINGi 4896.SPBC713.02c-1.

Protein family/group databases

MEROPSi C19.A59.

Proteomic databases

MaxQBi Q9UTT1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC713.02c.1 ; SPBC713.02c.1:pep ; SPBC713.02c .
GeneIDi 2541131.
KEGGi spo:SPBC713.02c.

Organism-specific databases

PomBasei SPBC713.02c.

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000160240.
KOi K11838.
OMAi YKLQDAN.
OrthoDBi EOG7C2R8P.
PhylomeDBi Q9UTT1.

Miscellaneous databases

NextBioi 20802244.
PROi Q9UTT1.

Family and domain databases

InterProi IPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view ]
Pfami PF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view ]
SMARTi SM00061. MATH. 1 hit.
[Graphical view ]
SUPFAMi SSF49599. SSF49599. 2 hits.
PROSITEi PS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The deubiquitinating enzyme Ubp21p of fission yeast stabilizes a mutant form of protein kinase Prp4p."
    Richert K., Schmidt H., Gross T., Kaeufer N.F.
    Mol. Genet. Genomics 267:88-95(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiUBP21_SCHPO
AccessioniPrimary (citable) accession number: Q9UTT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: June 11, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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