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Q9UTT1 (UBP21_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 21

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 21
Ubiquitin thioesterase 21
Ubiquitin-specific-processing protease 21
Gene names
Name:ubp21
Synonyms:ubp15, ubpd
ORF Names:SPBC713.02c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length1129 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in regulating the steady-state levels of proteins including prp4. Ref.1

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus Ref.1.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 MATH domain.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11291129Ubiquitin carboxyl-terminal hydrolase 21
PRO_0000080614

Regions

Domain51 – 204154MATH
Domain230 – 545316USP

Sites

Active site2391Nucleophile By similarity
Active site4811Proton acceptor By similarity

Experimental info

Sequence conflict421H → D in AAF01440. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UTT1 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: 536681DD9E78EBF8

FASTA1,129130,832
        10         20         30         40         50         60 
MVLSNVDAEE VNMDSSMELE ESSQEPLRAD NYEEIYNSLV HHEPDLEEAA HASYSWVVKN 

        70         80         90        100        110        120 
FSTLEDKTYS PLFKAGHTTW RIVLFPKGCN QTEYASVFLE YLPQCKVEAI RKYEAELAAG 

       130        140        150        160        170        180 
KTPTIDPEIV NDETYSCCAQ FALSLSNVQD PTVMQINTSH HRFRSEVKDW GFTRFVDLRK 

       190        200        210        220        230        240 
IAVPTPEFPV PFLENDEICI SVTVRVLQDP TGVLWHSFVN YNSKKETGYV GLKNQGATCY 

       250        260        270        280        290        300 
MNSLLQSLFF TNIFRKTVYK IPTDNDDSRD SVAYALQRVF YNLEKQREPV STTELTRSFG 

       310        320        330        340        350        360 
WNSFDSFMQH DIQEFNRVLQ DNLEKKMKGT EVENALNDIF VGKMKSYVKC IDVNYESSRV 

       370        380        390        400        410        420 
EDFWDIQLNV KGMDTLEDSF RDAIQVETLT GDNKYYAEGH GLQDAHKGII FESLPNVLQL 

       430        440        450        460        470        480 
QLKRFDYDML RDMMVKINDR HEFPLEIDLE PYLSETADKS ESHVYVLHGV LVHGGDLHGG 

       490        500        510        520        530        540 
HYYALIKPEK DSNWFKFDDD RVTRATIKEV LEDNYGGEPA GRAKGYNGNP FKRFMNAYML 

       550        560        570        580        590        600 
VYFRKSRLDH ILSPVTAEDV PFHVRNTLDE EHRVVERKLL EREEQQIYRR VRVLTTDGFK 

       610        620        630        640        650        660 
KYHGFDMTDF SASDDDPVLI TTKIKRNANI WDLQKHLAGL LNRDTSGIRI WLMTNRQNRT 

       670        680        690        700        710        720 
VRVDLPLDKK TILVDQICDM HIRKDMDMRV YVEFLSEHNQ LLADFGATDD NDFDTYIFLK 

       730        740        750        760        770        780 
IFDYETQQIS GLADLHVSKN SPISSLSEWI REHLKWSSDV PITYYEEIKT GMVDVLDPNA 

       790        800        810        820        830        840 
SFEKSEIQVG DIICFEKKLV HDSSSDTSHP YKSALDLYDF MAHRVVITFE PRYSDDTNNG 

       850        860        870        880        890        900 
VFDLVLTTHT NYTDMARAVA NKLNVDPNYL QFTMAHLPSR TPRSVIRNPS KFTLQNAIPS 

       910        920        930        940        950        960 
TYSHNQNVVM FYEVLDITLS ELERKQLIRV HFLSNGISHE TQMEFYVDKE GTVEDILRQV 

       970        980        990       1000       1010       1020 
TQKVPLNAED ASRLRLYEVY NHRILKSHLP TDGIYDLNEF STAYVEVTPK EEQMQLKTDD 

      1030       1040       1050       1060       1070       1080 
AVSIVVQHFF KDLSRLHDIP FYFVLLRGET LKDLKKRLQK RLGYNDTQFS KVKLAVLQAQ 

      1090       1100       1110       1120 
SFGKPYYLTD DDEVLYGELE PQSHILGLDH PPANGSAQYH GMDQAIRMK 

« Hide

References

« Hide 'large scale' references
[1]"The deubiquitinating enzyme Ubp21p of fission yeast stabilizes a mutant form of protein kinase Prp4p."
Richert K., Schmidt H., Gross T., Kaeufer N.F.
Mol. Genet. Genomics 267:88-95(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF187961 Genomic DNA. Translation: AAF01440.1.
CU329671 Genomic DNA. Translation: CAC22603.1.
RefSeqNP_595341.1. NM_001021249.2.

3D structure databases

ProteinModelPortalQ9UTT1.
SMRQ9UTT1. Positions 224-575.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277646. 4 interactions.
IntActQ9UTT1. 1 interaction.
MINTMINT-4711257.
STRING4896.SPBC713.02c-1.

Protein family/group databases

MEROPSC19.A59.

Proteomic databases

MaxQBQ9UTT1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC713.02c.1; SPBC713.02c.1:pep; SPBC713.02c.
GeneID2541131.
KEGGspo:SPBC713.02c.

Organism-specific databases

PomBaseSPBC713.02c.

Phylogenomic databases

eggNOGCOG5077.
HOGENOMHOG000160240.
KOK11838.
OMAYKLQDAN.
OrthoDBEOG7C2R8P.
PhylomeDBQ9UTT1.

Family and domain databases

InterProIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMSSF49599. SSF49599. 2 hits.
PROSITEPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802244.
PROQ9UTT1.

Entry information

Entry nameUBP21_SCHPO
AccessionPrimary (citable) accession number: Q9UTT1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: June 11, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Peptidase families

Classification of peptidase families and list of entries