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Q9UTT1

- UBP21_SCHPO

UniProt

Q9UTT1 - UBP21_SCHPO

Protein

Ubiquitin carboxyl-terminal hydrolase 21

Gene

ubp21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Involved in regulating the steady-state levels of proteins including prp4.1 Publication

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei239 – 2391NucleophilePROSITE-ProRule annotation
    Active sitei481 – 4811Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: PomBase

    GO - Biological processi

    1. endocytosis Source: PomBase
    2. protein deubiquitination Source: PomBase
    3. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A59.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 21 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 21
    Ubiquitin thioesterase 21
    Ubiquitin-specific-processing protease 21
    Gene namesi
    Name:ubp21
    Synonyms:ubp15, ubpd
    ORF Names:SPBC713.02c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC713.02c.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cell division site Source: PomBase
    2. cytoplasm Source: PomBase
    3. cytosol Source: PomBase
    4. nucleus Source: PomBase
    5. transport vesicle Source: PomBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11291129Ubiquitin carboxyl-terminal hydrolase 21PRO_0000080614Add
    BLAST

    Proteomic databases

    MaxQBiQ9UTT1.

    Interactioni

    Protein-protein interaction databases

    BioGridi277646. 4 interactions.
    IntActiQ9UTT1. 1 interaction.
    MINTiMINT-4711257.
    STRINGi4896.SPBC713.02c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UTT1.
    SMRiQ9UTT1. Positions 224-575.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 204154MATHPROSITE-ProRule annotationAdd
    BLAST
    Domaini230 – 545316USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 MATH domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    HOGENOMiHOG000160240.
    KOiK11838.
    OMAiYKLQDAN.
    OrthoDBiEOG7C2R8P.
    PhylomeDBiQ9UTT1.

    Family and domain databases

    InterProiIPR002083. MATH.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR008974. TRAF-like.
    IPR028889. UCH/PAN2.
    IPR024729. USP7_ICP0-binding_dom.
    IPR029346. USP_C.
    [Graphical view]
    PfamiPF00917. MATH. 1 hit.
    PF00443. UCH. 1 hit.
    PF14533. USP7_C2. 1 hit.
    PF12436. USP7_ICP0_bdg. 1 hit.
    [Graphical view]
    SMARTiSM00061. MATH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49599. SSF49599. 2 hits.
    PROSITEiPS50144. MATH. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UTT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLSNVDAEE VNMDSSMELE ESSQEPLRAD NYEEIYNSLV HHEPDLEEAA     50
    HASYSWVVKN FSTLEDKTYS PLFKAGHTTW RIVLFPKGCN QTEYASVFLE 100
    YLPQCKVEAI RKYEAELAAG KTPTIDPEIV NDETYSCCAQ FALSLSNVQD 150
    PTVMQINTSH HRFRSEVKDW GFTRFVDLRK IAVPTPEFPV PFLENDEICI 200
    SVTVRVLQDP TGVLWHSFVN YNSKKETGYV GLKNQGATCY MNSLLQSLFF 250
    TNIFRKTVYK IPTDNDDSRD SVAYALQRVF YNLEKQREPV STTELTRSFG 300
    WNSFDSFMQH DIQEFNRVLQ DNLEKKMKGT EVENALNDIF VGKMKSYVKC 350
    IDVNYESSRV EDFWDIQLNV KGMDTLEDSF RDAIQVETLT GDNKYYAEGH 400
    GLQDAHKGII FESLPNVLQL QLKRFDYDML RDMMVKINDR HEFPLEIDLE 450
    PYLSETADKS ESHVYVLHGV LVHGGDLHGG HYYALIKPEK DSNWFKFDDD 500
    RVTRATIKEV LEDNYGGEPA GRAKGYNGNP FKRFMNAYML VYFRKSRLDH 550
    ILSPVTAEDV PFHVRNTLDE EHRVVERKLL EREEQQIYRR VRVLTTDGFK 600
    KYHGFDMTDF SASDDDPVLI TTKIKRNANI WDLQKHLAGL LNRDTSGIRI 650
    WLMTNRQNRT VRVDLPLDKK TILVDQICDM HIRKDMDMRV YVEFLSEHNQ 700
    LLADFGATDD NDFDTYIFLK IFDYETQQIS GLADLHVSKN SPISSLSEWI 750
    REHLKWSSDV PITYYEEIKT GMVDVLDPNA SFEKSEIQVG DIICFEKKLV 800
    HDSSSDTSHP YKSALDLYDF MAHRVVITFE PRYSDDTNNG VFDLVLTTHT 850
    NYTDMARAVA NKLNVDPNYL QFTMAHLPSR TPRSVIRNPS KFTLQNAIPS 900
    TYSHNQNVVM FYEVLDITLS ELERKQLIRV HFLSNGISHE TQMEFYVDKE 950
    GTVEDILRQV TQKVPLNAED ASRLRLYEVY NHRILKSHLP TDGIYDLNEF 1000
    STAYVEVTPK EEQMQLKTDD AVSIVVQHFF KDLSRLHDIP FYFVLLRGET 1050
    LKDLKKRLQK RLGYNDTQFS KVKLAVLQAQ SFGKPYYLTD DDEVLYGELE 1100
    PQSHILGLDH PPANGSAQYH GMDQAIRMK 1129
    Length:1,129
    Mass (Da):130,832
    Last modified:August 14, 2001 - v2
    Checksum:i536681DD9E78EBF8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421H → D in AAF01440. (PubMed:11919719)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF187961 Genomic DNA. Translation: AAF01440.1.
    CU329671 Genomic DNA. Translation: CAC22603.1.
    RefSeqiNP_595341.1. NM_001021249.2.

    Genome annotation databases

    EnsemblFungiiSPBC713.02c.1; SPBC713.02c.1:pep; SPBC713.02c.
    GeneIDi2541131.
    KEGGispo:SPBC713.02c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF187961 Genomic DNA. Translation: AAF01440.1 .
    CU329671 Genomic DNA. Translation: CAC22603.1 .
    RefSeqi NP_595341.1. NM_001021249.2.

    3D structure databases

    ProteinModelPortali Q9UTT1.
    SMRi Q9UTT1. Positions 224-575.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277646. 4 interactions.
    IntActi Q9UTT1. 1 interaction.
    MINTi MINT-4711257.
    STRINGi 4896.SPBC713.02c-1.

    Protein family/group databases

    MEROPSi C19.A59.

    Proteomic databases

    MaxQBi Q9UTT1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC713.02c.1 ; SPBC713.02c.1:pep ; SPBC713.02c .
    GeneIDi 2541131.
    KEGGi spo:SPBC713.02c.

    Organism-specific databases

    PomBasei SPBC713.02c.

    Phylogenomic databases

    eggNOGi COG5077.
    HOGENOMi HOG000160240.
    KOi K11838.
    OMAi YKLQDAN.
    OrthoDBi EOG7C2R8P.
    PhylomeDBi Q9UTT1.

    Miscellaneous databases

    NextBioi 20802244.
    PROi Q9UTT1.

    Family and domain databases

    InterProi IPR002083. MATH.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR008974. TRAF-like.
    IPR028889. UCH/PAN2.
    IPR024729. USP7_ICP0-binding_dom.
    IPR029346. USP_C.
    [Graphical view ]
    Pfami PF00917. MATH. 1 hit.
    PF00443. UCH. 1 hit.
    PF14533. USP7_C2. 1 hit.
    PF12436. USP7_ICP0_bdg. 1 hit.
    [Graphical view ]
    SMARTi SM00061. MATH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49599. SSF49599. 2 hits.
    PROSITEi PS50144. MATH. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The deubiquitinating enzyme Ubp21p of fission yeast stabilizes a mutant form of protein kinase Prp4p."
      Richert K., Schmidt H., Gross T., Kaeufer N.F.
      Mol. Genet. Genomics 267:88-95(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiUBP21_SCHPO
    AccessioniPrimary (citable) accession number: Q9UTT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3