Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable L-asparaginase 2

Gene

SPAC977.12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-asparagine + H2O = L-aspartate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46O-isoaspartyl threonine intermediateBy similarity1
Binding sitei93SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-SPO-70614. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-asparaginase 2 (EC:3.5.1.1)
Alternative name(s):
L-asparagine amidohydrolase 2
Gene namesi
ORF Names:SPAC977.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC977.12.
PomBaseiSPAC977.12.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: UniProtKB-SubCell
  • cell wall-bounded periplasmic space Source: GO_Central
  • cytoplasm Source: GO_Central
  • extracellular region Source: UniProtKB-KW
  • Golgi apparatus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000236423 – 356Probable L-asparaginase 2Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9UTS7.
PRIDEiQ9UTS7.

PTM databases

SwissPalmiQ9UTS7.

Interactioni

Protein-protein interaction databases

MINTiMINT-4711236.

Structurei

3D structure databases

ProteinModelPortaliQ9UTS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 356Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST321

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 127Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the asparaginase 1 family.Curated
Contains 1 asparaginase/glutaminase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000044165.
InParanoidiQ9UTS7.
KOiK01424.
OMAiWPLALEN.
OrthoDBiEOG092C3Z6Q.
PhylomeDBiQ9UTS7.

Family and domain databases

Gene3Di3.40.50.1170. 1 hit.
3.40.50.40. 1 hit.
InterProiIPR004550. AsnASE_II.
IPR006034. Asparaginase/glutaminase.
IPR027473. L-asparaginase_C.
IPR027474. L-asparaginase_N.
[Graphical view]
PfamiPF00710. Asparaginase. 1 hit.
[Graphical view]
PIRSFiPIRSF001220. L-ASNase_gatD. 1 hit.
PRINTSiPR00139. ASNGLNASE.
SMARTiSM00870. Asparaginase. 1 hit.
[Graphical view]
SUPFAMiSSF53774. SSF53774. 1 hit.
TIGRFAMsiTIGR00520. asnASE_II. 1 hit.
PROSITEiPS51732. ASN_GLN_ASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UTS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGFIVTCGI FLVLLCQLRL LSKRKSKSTP YNALLPNVTV FAMGGTIAGC
60 70 80 90 100
ANSSLEIVNY IPGSVGIEKL IEAVPAIKAI ANINGVQVTN MGSENLTPAD
110 120 130 140 150
VLKLAKLILA EVAKPNVHGI VITHGTDSLE ETAMFLDLTI STAKPIVVVG
160 170 180 190 200
AMRPSTAIGA DGPMNLLNAV AVASSNQSMG RGTLVLLNDR IGSAFYTTKT
210 220 230 240 250
NGNTLDTFKS YEAGSLGIVL NQKPFYFFSP AVPTGKVFFD IYNIKQLPRV
260 270 280 290 300
DILYGYQGLN PKLAESAVHL GAKGLVLAAM GATSWTDDGN EVISSLIREH
310 320 330 340 350
NIPVVYSHRT AEGYSSNSCL GIPSYFLNPQ KARYMLMLAI SSGYSIRDIE

DLFSIK
Length:356
Mass (Da):38,115
Last modified:May 1, 2000 - v1
Checksum:iE7935A592DB2BFDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192974 Genomic DNA. Translation: AAF13924.1.
CU329670 Genomic DNA. Translation: CAB69634.1.
PIRiT50284.
RefSeqiNP_592784.1. NM_001018184.2.

Genome annotation databases

EnsemblFungiiSPAC977.12.1; SPAC977.12.1:pep; SPAC977.12.
GeneIDi2543314.
KEGGispo:SPAC977.12.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192974 Genomic DNA. Translation: AAF13924.1.
CU329670 Genomic DNA. Translation: CAB69634.1.
PIRiT50284.
RefSeqiNP_592784.1. NM_001018184.2.

3D structure databases

ProteinModelPortaliQ9UTS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4711236.

PTM databases

SwissPalmiQ9UTS7.

Proteomic databases

MaxQBiQ9UTS7.
PRIDEiQ9UTS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC977.12.1; SPAC977.12.1:pep; SPAC977.12.
GeneIDi2543314.
KEGGispo:SPAC977.12.

Organism-specific databases

EuPathDBiFungiDB:SPAC977.12.
PomBaseiSPAC977.12.

Phylogenomic databases

HOGENOMiHOG000044165.
InParanoidiQ9UTS7.
KOiK01424.
OMAiWPLALEN.
OrthoDBiEOG092C3Z6Q.
PhylomeDBiQ9UTS7.

Enzyme and pathway databases

ReactomeiR-SPO-70614. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

PROiQ9UTS7.

Family and domain databases

Gene3Di3.40.50.1170. 1 hit.
3.40.50.40. 1 hit.
InterProiIPR004550. AsnASE_II.
IPR006034. Asparaginase/glutaminase.
IPR027473. L-asparaginase_C.
IPR027474. L-asparaginase_N.
[Graphical view]
PfamiPF00710. Asparaginase. 1 hit.
[Graphical view]
PIRSFiPIRSF001220. L-ASNase_gatD. 1 hit.
PRINTSiPR00139. ASNGLNASE.
SMARTiSM00870. Asparaginase. 1 hit.
[Graphical view]
SUPFAMiSSF53774. SSF53774. 1 hit.
TIGRFAMsiTIGR00520. asnASE_II. 1 hit.
PROSITEiPS51732. ASN_GLN_ASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASPG2_SCHPO
AccessioniPrimary (citable) accession number: Q9UTS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.