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Protein

Probable L-asparaginase 2

Gene

SPAC977.12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-asparagine + H2O = L-aspartate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46O-isoaspartyl threonine intermediateBy similarity1
Binding sitei93SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-SPO-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-asparaginase 2 (EC:3.5.1.1)
Alternative name(s):
L-asparagine amidohydrolase 2
Gene namesi
ORF Names:SPAC977.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC977.12
PomBaseiSPAC977.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000236423 – 356Probable L-asparaginase 2Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9UTS7
PaxDbiQ9UTS7
PRIDEiQ9UTS7

PTM databases

SwissPalmiQ9UTS7

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC977.12.1

Structurei

3D structure databases

ProteinModelPortaliQ9UTS7
SMRiQ9UTS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 356Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST321

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 127Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the asparaginase 1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000044165
InParanoidiQ9UTS7
KOiK01424
OMAiARYITKT
OrthoDBiEOG092C3Z6Q
PhylomeDBiQ9UTS7

Family and domain databases

Gene3Di3.40.50.1170, 1 hit
3.40.50.40, 1 hit
InterProiView protein in InterPro
IPR004550 AsnASE_II
IPR036152 Asp/glu_Ase-like_sf
IPR006034 Asparaginase/glutaminase-like
IPR027473 L-asparaginase_C
IPR027474 L-asparaginase_N
IPR037152 L-asparaginase_N_sf
PfamiView protein in Pfam
PF00710 Asparaginase, 1 hit
PIRSFiPIRSF001220 L-ASNase_gatD, 1 hit
PRINTSiPR00139 ASNGLNASE
SMARTiView protein in SMART
SM00870 Asparaginase, 1 hit
SUPFAMiSSF53774 SSF53774, 1 hit
TIGRFAMsiTIGR00520 asnASE_II, 1 hit
PROSITEiView protein in PROSITE
PS51732 ASN_GLN_ASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UTS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGFIVTCGI FLVLLCQLRL LSKRKSKSTP YNALLPNVTV FAMGGTIAGC
60 70 80 90 100
ANSSLEIVNY IPGSVGIEKL IEAVPAIKAI ANINGVQVTN MGSENLTPAD
110 120 130 140 150
VLKLAKLILA EVAKPNVHGI VITHGTDSLE ETAMFLDLTI STAKPIVVVG
160 170 180 190 200
AMRPSTAIGA DGPMNLLNAV AVASSNQSMG RGTLVLLNDR IGSAFYTTKT
210 220 230 240 250
NGNTLDTFKS YEAGSLGIVL NQKPFYFFSP AVPTGKVFFD IYNIKQLPRV
260 270 280 290 300
DILYGYQGLN PKLAESAVHL GAKGLVLAAM GATSWTDDGN EVISSLIREH
310 320 330 340 350
NIPVVYSHRT AEGYSSNSCL GIPSYFLNPQ KARYMLMLAI SSGYSIRDIE

DLFSIK
Length:356
Mass (Da):38,115
Last modified:May 1, 2000 - v1
Checksum:iE7935A592DB2BFDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192974 Genomic DNA Translation: AAF13924.1
CU329670 Genomic DNA Translation: CAB69634.1
PIRiT50284
RefSeqiNP_592784.1, NM_001018184.2

Genome annotation databases

EnsemblFungiiSPAC977.12.1; SPAC977.12.1:pep; SPAC977.12
GeneIDi2543314
KEGGispo:SPAC977.12

Similar proteinsi

Entry informationi

Entry nameiASPG2_SCHPO
AccessioniPrimary (citable) accession number: Q9UTS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health