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Q9UTQ1

- PDX3_SCHPO

UniProt

Q9UTQ1 - PDX3_SCHPO

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Protein

Probable pyridoxamine 5'-phosphate oxidase

Gene

SPAC1093.02

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).By similarity

Catalytic activityi

Pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2.
Pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2.

Cofactori

Binds 1 FMN per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei74 – 741FMNBy similarity
Binding sitei77 – 771FMN; via amide nitrogenBy similarity
Binding sitei79 – 791SubstrateBy similarity
Binding sitei97 – 971FMNBy similarity
Binding sitei137 – 1371SubstrateBy similarity
Binding sitei141 – 1411SubstrateBy similarity
Binding sitei145 – 1451SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 902FMNBy similarity
Nucleotide bindingi154 – 1552FMNBy similarity

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. pyridoxamine-phosphate oxidase activity Source: PomBase

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: GOC
  2. pyridoxamine metabolic process Source: PomBase
  3. pyridoxine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

ReactomeiREACT_188557. Vitamins B6 activation to pyridoxal phosphate.
UniPathwayiUPA00190; UER00304.
UPA00190; UER00305.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable pyridoxamine 5'-phosphate oxidase (EC:1.4.3.5)
Alternative name(s):
PNP/PMP oxidase
Short name:
PNPOx
Gene namesi
ORF Names:SPAC1093.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1093.02.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Probable pyridoxamine 5'-phosphate oxidasePRO_0000167786Add
BLAST

Proteomic databases

MaxQBiQ9UTQ1.
PaxDbiQ9UTQ1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi279436. 2 interactions.
STRINGi4896.SPAC1093.02-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UTQ1.
SMRiQ9UTQ1. Positions 25-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni208 – 2103Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0259.
HOGENOMiHOG000242755.
InParanoidiQ9UTQ1.
KOiK00275.
OMAiELDHRGF.
OrthoDBiEOG7WDNF3.
PhylomeDBiQ9UTQ1.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
HAMAPiMF_01629. PdxH.
InterProiIPR000659. Pyridox_Oxase.
IPR019740. Pyridox_Oxase_CS.
IPR011576. Pyridox_Oxase_FMN-bd.
IPR019576. Pyridoxamine_oxidase_dimer_C.
IPR012349. Split_barrel_FMN-bd.
[Graphical view]
PANTHERiPTHR10851. PTHR10851. 1 hit.
PfamiPF10590. PNPOx_C. 1 hit.
PF01243. Pyridox_oxidase. 1 hit.
[Graphical view]
PIRSFiPIRSF000190. Pyd_amn-ph_oxd. 1 hit.
SUPFAMiSSF50475. SSF50475. 1 hit.
TIGRFAMsiTIGR00558. pdxH. 1 hit.
PROSITEiPS01064. PYRIDOX_OXIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UTQ1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSENTDSTHE KLIFAPSRYQ YEKSSLHRDA LMGKDPLVLF NQWFQEATDD
60 70 80 90 100
EGIKSPESTT LSTARLPSGR VSSRLVLLKE LDHRGFIIFT NLGTSKKAKD
110 120 130 140 150
LKSNPYASLS FWWEPLQRQV RVEGIIERLS REETEEYFKT RPRNSRIGAW
160 170 180 190 200
ASPQSEVIAD REELEKRVEE YKKKFGEDES VPVPVPDFWG GIRIVPLEIE
210 220 230
FWQGGKYRLH DRFSFRRNTL DEDYELVRLA P
Length:231
Mass (Da):27,014
Last modified:May 1, 2000 - v1
Checksum:i124AC10D144CD9F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB60247.1.
PIRiT50066.
RefSeqiNP_594650.1. NM_001020078.2.

Genome annotation databases

EnsemblFungiiSPAC1093.02.1; SPAC1093.02.1:pep; SPAC1093.02.
GeneIDi2542998.
KEGGispo:SPAC1093.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB60247.1 .
PIRi T50066.
RefSeqi NP_594650.1. NM_001020078.2.

3D structure databases

ProteinModelPortali Q9UTQ1.
SMRi Q9UTQ1. Positions 25-231.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279436. 2 interactions.
STRINGi 4896.SPAC1093.02-1.

Proteomic databases

MaxQBi Q9UTQ1.
PaxDbi Q9UTQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1093.02.1 ; SPAC1093.02.1:pep ; SPAC1093.02 .
GeneIDi 2542998.
KEGGi spo:SPAC1093.02.

Organism-specific databases

PomBasei SPAC1093.02.

Phylogenomic databases

eggNOGi COG0259.
HOGENOMi HOG000242755.
InParanoidi Q9UTQ1.
KOi K00275.
OMAi ELDHRGF.
OrthoDBi EOG7WDNF3.
PhylomeDBi Q9UTQ1.

Enzyme and pathway databases

UniPathwayi UPA00190 ; UER00304 .
UPA00190 ; UER00305 .
Reactomei REACT_188557. Vitamins B6 activation to pyridoxal phosphate.

Miscellaneous databases

NextBioi 20804031.
PROi Q9UTQ1.

Family and domain databases

Gene3Di 2.30.110.10. 1 hit.
HAMAPi MF_01629. PdxH.
InterProi IPR000659. Pyridox_Oxase.
IPR019740. Pyridox_Oxase_CS.
IPR011576. Pyridox_Oxase_FMN-bd.
IPR019576. Pyridoxamine_oxidase_dimer_C.
IPR012349. Split_barrel_FMN-bd.
[Graphical view ]
PANTHERi PTHR10851. PTHR10851. 1 hit.
Pfami PF10590. PNPOx_C. 1 hit.
PF01243. Pyridox_oxidase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000190. Pyd_amn-ph_oxd. 1 hit.
SUPFAMi SSF50475. SSF50475. 1 hit.
TIGRFAMsi TIGR00558. pdxH. 1 hit.
PROSITEi PS01064. PYRIDOX_OXIDASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPDX3_SCHPO
AccessioniPrimary (citable) accession number: Q9UTQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3