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Protein

ATP-dependent RNA helicase dbp4

Gene

dbp4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi83 – 908ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase dbp4 (EC:3.6.4.13)
Gene namesi
Name:dbp4
ORF Names:SPAC1093.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1093.05.
PomBaseiSPAC1093.05.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735ATP-dependent RNA helicase dbp4PRO_0000232203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei500 – 5001Phosphoserine1 Publication
Modified residuei503 – 5031Phosphoserine1 Publication
Modified residuei504 – 5041Phosphoserine1 Publication
Modified residuei545 – 5451Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UTP9.

PTM databases

iPTMnetiQ9UTP9.

Interactioni

Subunit structurei

Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes (By similarity).By similarity

Protein-protein interaction databases

BioGridi278126. 1 interaction.
MINTiMINT-4711052.

Structurei

3D structure databases

ProteinModelPortaliQ9UTP9.
SMRiQ9UTP9. Positions 20-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 244175Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini270 – 424155Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 6729Q motifAdd
BLAST
Motifi192 – 1954DEAD box

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000268801.
InParanoidiQ9UTP9.
KOiK14776.
OMAiIMDMGFQ.
OrthoDBiEOG092C1VLP.
PhylomeDBiQ9UTP9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UTP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKNRTGRSR EAREKKRKEE EEEIEELNSQ IEALSETVDH FAELPLTQPT
60 70 80 90 100
KSALKNAHFI TLTEIQKQCI PSALKGRDIL GAAKTGSGKT LAFIVPLIEN
110 120 130 140 150
LYRKKWTSLD GLGALVISPT RELAIQTFET LVKIGRLHSF SAGLIIGGNN
160 170 180 190 200
YKEEKERLSR MNILVCTPGR LLQHIDQAVN FDTSGLQMLI LDEADRILDM
210 220 230 240 250
GFRTTLDAIV SSLPVHRQTM LFSATQTKSV KDLARLSLQN PDFISVHEND
260 270 280 290 300
TSSTPSNLNQ FYLTVPLTEK LDILFGFIRT HLKFKTIVFL SSCKQVRFVY
310 320 330 340 350
ETFRRMRPGI SLLHLHGKQK QTTRTEVTAK FTSSRHVVLF CTDIVARGLD
360 370 380 390 400
FPAVDWVIQL DAPEDVDTYI HRVGRTARYN RSGNALLLLL PSEEAFLKRL
410 420 430 440 450
ESKKIAVERI NVKDGKKTSI RNQLQNLCFK DNDIKYIGQK AFISYLRSIY
460 470 480 490 500
LQKDKDVFQL DKLPVEAFAD SLGLPGTPKI TFGKLKNHSQ SQKDYNSSTS
510 520 530 540 550
LDSSEESEVD VENKQNVRTK YDRIFERKNQ DVLAAHRQRL VEVNSDEDDG
560 570 580 590 600
DFLQVKRVDH DLPEETGERF NANSKRKEKM ASSKKAMLKY KKSADKVYFD
610 620 630 640 650
DEGNAIPFYA MNTEDTFQKA GDPAALIASH LAEERKALEK ADITDKETVR
660 670 680 690 700
QKQLEKKRRR QELERITQQD ATPDEYVPEG PIVAFVDDEL PETSKKQKKW
710 720 730
FEDNDERDHG GIVEVENLNS LEDQEALALK LMGAA
Length:735
Mass (Da):83,671
Last modified:May 1, 2000 - v1
Checksum:i43A06F5AA29533FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB60250.1.
PIRiT50068.
RefSeqiNP_594652.1. NM_001020081.2.

Genome annotation databases

EnsemblFungiiSPAC1093.05.1; SPAC1093.05.1:pep; SPAC1093.05.
GeneIDi2541630.
KEGGispo:SPAC1093.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB60250.1.
PIRiT50068.
RefSeqiNP_594652.1. NM_001020081.2.

3D structure databases

ProteinModelPortaliQ9UTP9.
SMRiQ9UTP9. Positions 20-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278126. 1 interaction.
MINTiMINT-4711052.

PTM databases

iPTMnetiQ9UTP9.

Proteomic databases

MaxQBiQ9UTP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1093.05.1; SPAC1093.05.1:pep; SPAC1093.05.
GeneIDi2541630.
KEGGispo:SPAC1093.05.

Organism-specific databases

EuPathDBiFungiDB:SPAC1093.05.
PomBaseiSPAC1093.05.

Phylogenomic databases

HOGENOMiHOG000268801.
InParanoidiQ9UTP9.
KOiK14776.
OMAiIMDMGFQ.
OrthoDBiEOG092C1VLP.
PhylomeDBiQ9UTP9.

Miscellaneous databases

PROiQ9UTP9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDBP4_SCHPO
AccessioniPrimary (citable) accession number: Q9UTP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.