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Protein

Ubiquitin-conjugating enzyme E2 14

Gene

ubc14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins.PROSITE-ProRule annotationBy similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotationBy similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotationBy similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Glycyl thioester intermediatePROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 14By similarityImported (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 14
Ubiquitin carrier protein 14By similarity
Ubiquitin-protein ligase 14By similarity
Gene namesi
Name:ubc14
ORF Names:SPAC1250.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPAC1250.03
PomBaseiSPAC1250.03 ubc14

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003610531 – 155Ubiquitin-conjugating enzyme E2 14Add BLAST155

Proteomic databases

MaxQBiQ9UTN8
PaxDbiQ9UTN8
PRIDEiQ9UTN8

Interactioni

Protein-protein interaction databases

BioGridi278063, 14 interactors
STRINGi4896.SPAC1250.03.1

Structurei

3D structure databases

ProteinModelPortaliQ9UTN8
SMRiQ9UTN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233455
InParanoidiQ9UTN8
OMAiKPPTVSF
OrthoDBiEOG092C50OL
PhylomeDBiQ9UTN8

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UTN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASASPSSSR RLTKEYSDLR EHPIPDIRVN LVDDNLFHWA CTALGPSDSV
60 70 80 90 100
YAGGKFHFSL KFPLDYPFQP PTIEFTTRIY HPNFDSEGNV CLAILKQQVF
110 120 130 140 150
KPSIKLRSVL EQILQLLREP NPDDPLVASI AEQYRNDRPS FDKIARDYVE

QFAKS
Length:155
Mass (Da):17,743
Last modified:May 1, 2000 - v1
Checksum:i76E66013E5C2BE05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB54826.1
PIRiT37559
RefSeqiNP_594859.1, NM_001020288.2

Genome annotation databases

EnsemblFungiiSPAC1250.03.1; SPAC1250.03.1:pep; SPAC1250.03
GeneIDi2541565
KEGGispo:SPAC1250.03

Similar proteinsi

Entry informationi

Entry nameiUBC14_SCHPO
AccessioniPrimary (citable) accession number: Q9UTN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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