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Protein

Poly(A) RNA polymerase cid14

Gene

cid14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for 3' polyadenylation of the 5.8S and 25S rRNAs as a prelude to their degradation in the exosome. Involved in the nucleolar organization to ensure faithful chromosome segregation during mitosis.1 Publication

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi298Magnesium or manganese; catalyticBy similarity1
Metal bindingi300Magnesium or manganese; catalyticBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • polynucleotide adenylyltransferase activity Source: PomBase
  • ribosomal large subunit binding Source: PomBase
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process Source: PomBase
  • nuclear polyadenylation-dependent rRNA catabolic process Source: PomBase
  • RNA processing Source: PomBase
  • snoRNA catabolic process Source: PomBase
  • tRNA catabolic process Source: PomBase

Keywordsi

Molecular functionRNA-binding, Transferase
Biological processmRNA processing
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.7.19 5613

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) RNA polymerase cid14 (EC:2.7.7.19)
Short name:
PAP
Alternative name(s):
Caffeine-induced death protein 14
Polynucleotide adenylyltransferase cid14
Gene namesi
Name:cid14
ORF Names:SPAC12G12.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC12G12.13c
PomBaseiSPAC12G12.13c cid14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897461 – 684Poly(A) RNA polymerase cid14Add BLAST684

Proteomic databases

MaxQBiQ9UTN3
PaxDbiQ9UTN3
PRIDEiQ9UTN3

PTM databases

iPTMnetiQ9UTN3

Interactioni

Subunit structurei

Heterooligomer. Interacts with air1.2 Publications

Protein-protein interaction databases

BioGridi280460, 147 interactors
STRINGi4896.SPAC12G12.13c.1

Structurei

3D structure databases

ProteinModelPortaliQ9UTN3
SMRiQ9UTN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini434 – 492PAP-associatedAdd BLAST59

Sequence similaritiesi

Belongs to the DNA polymerase type-B-like family.Curated

Phylogenomic databases

InParanoidiQ9UTN3
KOiK03514
OMAiFHEANEK
OrthoDBiEOG092C144L
PhylomeDBiQ9UTN3

Family and domain databases

InterProiView protein in InterPro
IPR002058 PAP_assoc
IPR002934 Polymerase_NTP_transf_dom
PfamiView protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF03828 PAP_assoc, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UTN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKSVSFNR NNYKKRKNER TEPLPRRIFK NDKPSKFKSK RKEKDKNSDA
60 70 80 90 100
YDEMLLNNNF TLLDQEEPMV EIGSKKSRND NDSEGIRDKG GVEISNKNDP
110 120 130 140 150
YIQFGKADPL EPLEKPDLPE EAIKRGEPTI LLGIPKREGR KTNPVHDKAV
160 170 180 190 200
ENNSDFIKFD WNSDEDEDSV SNDKSKNNES LKKSSKNEIP GFMRQRGRFF
210 220 230 240 250
HEANEKSDSN RKRKRQAYEL DSQSCPWHRQ YKVEREVSRI FHQDILHFID
260 270 280 290 300
YITPTPEEHA VRKTLVSRIN QAVLQKWPDV SLYVFGSFET KLYLPTSDLD
310 320 330 340 350
LVIISPEHHY RGTKKDMFVL AHHLKKLKLA SEVQVITTAN VPIIKFVDPL
360 370 380 390 400
TKVHVDISFN QPGGLKTCLV VNGFMKKYPA LRPLVIIIKH FLNMRALNEV
410 420 430 440 450
FLGGLSSYAI VCLVVSFLQL HPRLSTGSMR EEDNFGVLLL EFLELYGKQF
460 470 480 490 500
YYDAVGIAVH NGGFYFSKKK MGWLKPNQPY LLSIQDPVDF QNDVSKSSRG
510 520 530 540 550
LLRVKATFAN GFDLLTSKLY ALASRIEREG VNRVKDFPSI LSTILSVDEG
560 570 580 590 600
VRQHREHMLK CYKNNPVPLE PLVEVDALAS IDVDKLPLQD VGLQYVEDES
610 620 630 640 650
DSDETDAAKD DLFKVNESIE TNGHENFQKQ ALTSTGEQSS SNSRANPSKL
660 670 680
FNISSDDSED EVPIIEDTTA SDEESRAKKI RKRF
Length:684
Mass (Da):78,298
Last modified:November 8, 2005 - v2
Checksum:iC2CF653A51C8D39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAI79317.1
PIRiS62544
RefSeqiNP_001018181.1, NM_001018285.2

Genome annotation databases

EnsemblFungiiSPAC12G12.13c.1; SPAC12G12.13c.1:pep; SPAC12G12.13c
GeneIDi3361384
KEGGispo:SPAC12G12.13c

Similar proteinsi

Entry informationi

Entry nameiCID14_SCHPO
AccessioniPrimary (citable) accession number: Q9UTN3
Secondary accession number(s): Q09876, Q565C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health