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Q9UTN3

- CID14_SCHPO

UniProt

Q9UTN3 - CID14_SCHPO

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Protein
Poly(A) RNA polymerase cid14
Gene
cid14, SPAC12G12.13c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for 3' polyadenylation of the 5.8S and 25S rRNAs as a prelude ot their degradation in the exosome. Involved in the nucleolar organization to ensure faithful chromosome segregation during mitosis.1 Publication

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi298 – 2981Magnesium or manganese; catalytic By similarity
Metal bindingi300 – 3001Magnesium or manganese; catalytic By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. polynucleotide adenylyltransferase activity Source: PomBase
  5. ribosomal large subunit binding Source: PomBase

GO - Biological processi

  1. biological regulation Source: PomBase
  2. mRNA processing Source: UniProtKB-KW
  3. mitotic nuclear division Source: UniProtKB-KW
  4. ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process Source: PomBase
  5. nucleolus organization Source: PomBase
  6. rRNA 3'-end processing Source: PomBase
  7. rRNA catabolic process Source: PomBase
  8. snoRNA catabolic process Source: PomBase
  9. tRNA catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) RNA polymerase cid14 (EC:2.7.7.19)
Short name:
PAP
Alternative name(s):
Caffeine-induced death protein 14
Polynucleotide adenylyltransferase cid14
Gene namesi
Name:cid14
ORF Names:SPAC12G12.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC12G12.13c.

Subcellular locationi

Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. TRAMP complex Source: PomBase
  2. nucleolus Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 684684Poly(A) RNA polymerase cid14
PRO_0000089746Add
BLAST

Proteomic databases

MaxQBiQ9UTN3.

Interactioni

Subunit structurei

Heterooligomer. Interacts with air1.2 Publications

Protein-protein interaction databases

BioGridi280460. 146 interactions.
MINTiMINT-4710930.
STRINGi4896.SPAC12G12.13c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UTN3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini434 – 49259PAP-associated
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5260.
KOiK03514.
OMAiLISHEEE.
OrthoDBiEOG7CNZS6.
PhylomeDBiQ9UTN3.

Family and domain databases

InterProiIPR002934. Nucleotidyltransferase.
IPR002058. PAP_assoc.
[Graphical view]
PfamiPF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UTN3-1 [UniParc]FASTAAdd to Basket

« Hide

MGKKSVSFNR NNYKKRKNER TEPLPRRIFK NDKPSKFKSK RKEKDKNSDA    50
YDEMLLNNNF TLLDQEEPMV EIGSKKSRND NDSEGIRDKG GVEISNKNDP 100
YIQFGKADPL EPLEKPDLPE EAIKRGEPTI LLGIPKREGR KTNPVHDKAV 150
ENNSDFIKFD WNSDEDEDSV SNDKSKNNES LKKSSKNEIP GFMRQRGRFF 200
HEANEKSDSN RKRKRQAYEL DSQSCPWHRQ YKVEREVSRI FHQDILHFID 250
YITPTPEEHA VRKTLVSRIN QAVLQKWPDV SLYVFGSFET KLYLPTSDLD 300
LVIISPEHHY RGTKKDMFVL AHHLKKLKLA SEVQVITTAN VPIIKFVDPL 350
TKVHVDISFN QPGGLKTCLV VNGFMKKYPA LRPLVIIIKH FLNMRALNEV 400
FLGGLSSYAI VCLVVSFLQL HPRLSTGSMR EEDNFGVLLL EFLELYGKQF 450
YYDAVGIAVH NGGFYFSKKK MGWLKPNQPY LLSIQDPVDF QNDVSKSSRG 500
LLRVKATFAN GFDLLTSKLY ALASRIEREG VNRVKDFPSI LSTILSVDEG 550
VRQHREHMLK CYKNNPVPLE PLVEVDALAS IDVDKLPLQD VGLQYVEDES 600
DSDETDAAKD DLFKVNESIE TNGHENFQKQ ALTSTGEQSS SNSRANPSKL 650
FNISSDDSED EVPIIEDTTA SDEESRAKKI RKRF 684
Length:684
Mass (Da):78,298
Last modified:November 8, 2005 - v2
Checksum:iC2CF653A51C8D39B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAI79317.1.
PIRiS62544.
RefSeqiNP_001018181.1. NM_001018285.2.

Genome annotation databases

EnsemblFungiiSPAC12G12.13c.1; SPAC12G12.13c.1:pep; SPAC12G12.13c.
GeneIDi3361384.
KEGGispo:SPAC12G12.13c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAI79317.1 .
PIRi S62544.
RefSeqi NP_001018181.1. NM_001018285.2.

3D structure databases

ProteinModelPortali Q9UTN3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 280460. 146 interactions.
MINTi MINT-4710930.
STRINGi 4896.SPAC12G12.13c-1.

Proteomic databases

MaxQBi Q9UTN3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC12G12.13c.1 ; SPAC12G12.13c.1:pep ; SPAC12G12.13c .
GeneIDi 3361384.
KEGGi spo:SPAC12G12.13c.

Organism-specific databases

PomBasei SPAC12G12.13c.

Phylogenomic databases

eggNOGi COG5260.
KOi K03514.
OMAi LISHEEE.
OrthoDBi EOG7CNZS6.
PhylomeDBi Q9UTN3.

Miscellaneous databases

NextBioi 20811434.

Family and domain databases

InterProi IPR002934. Nucleotidyltransferase.
IPR002058. PAP_assoc.
[Graphical view ]
Pfami PF01909. NTP_transf_2. 1 hit.
PF03828. PAP_assoc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Requirement of fission yeast Cid14 in polyadenylation of rRNAs."
    Win T.Z., Draper S., Read R.L., Pearce J., Norbury C.J., Wang S.-W.
    Mol. Cell. Biol. 26:1710-1721(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. "RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing."
    Buehler M., Haas W., Gygi S.P., Moazed D.
    Cell 129:707-721(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AIR1.

Entry informationi

Entry nameiCID14_SCHPO
AccessioniPrimary (citable) accession number: Q9UTN3
Secondary accession number(s): Q09876, Q565C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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