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Q9UTN3

- CID14_SCHPO

UniProt

Q9UTN3 - CID14_SCHPO

Protein

Poly(A) RNA polymerase cid14

Gene

cid14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Required for 3' polyadenylation of the 5.8S and 25S rRNAs as a prelude ot their degradation in the exosome. Involved in the nucleolar organization to ensure faithful chromosome segregation during mitosis.1 Publication

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi298 – 2981Magnesium or manganese; catalyticBy similarity
    Metal bindingi300 – 3001Magnesium or manganese; catalyticBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. polynucleotide adenylyltransferase activity Source: PomBase
    4. ribosomal large subunit binding Source: PomBase
    5. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. biological regulation Source: PomBase
    2. mitotic nuclear division Source: UniProtKB-KW
    3. mRNA processing Source: UniProtKB-KW
    4. ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process Source: PomBase
    5. nucleolus organization Source: PomBase
    6. rRNA 3'-end processing Source: PomBase
    7. rRNA catabolic process Source: PomBase
    8. snoRNA catabolic process Source: PomBase
    9. tRNA catabolic process Source: PomBase

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) RNA polymerase cid14 (EC:2.7.7.19)
    Short name:
    PAP
    Alternative name(s):
    Caffeine-induced death protein 14
    Polynucleotide adenylyltransferase cid14
    Gene namesi
    Name:cid14
    ORF Names:SPAC12G12.13c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC12G12.13c.

    Subcellular locationi

    Nucleusnucleolus 2 Publications

    GO - Cellular componenti

    1. nucleolus Source: PomBase
    2. nucleus Source: PomBase
    3. TRAMP complex Source: PomBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 684684Poly(A) RNA polymerase cid14PRO_0000089746Add
    BLAST

    Proteomic databases

    MaxQBiQ9UTN3.

    Interactioni

    Subunit structurei

    Heterooligomer. Interacts with air1.2 Publications

    Protein-protein interaction databases

    BioGridi280460. 146 interactions.
    MINTiMINT-4710930.
    STRINGi4896.SPAC12G12.13c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UTN3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini434 – 49259PAP-associatedAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNA polymerase type-B-like family.Curated
    Contains 1 PAP-associated domain.Curated

    Phylogenomic databases

    eggNOGiCOG5260.
    KOiK03514.
    OMAiLISHEEE.
    OrthoDBiEOG7CNZS6.
    PhylomeDBiQ9UTN3.

    Family and domain databases

    InterProiIPR002934. Nucleotidyltransferase.
    IPR002058. PAP_assoc.
    [Graphical view]
    PfamiPF01909. NTP_transf_2. 1 hit.
    PF03828. PAP_assoc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UTN3-1 [UniParc]FASTAAdd to Basket

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    MGKKSVSFNR NNYKKRKNER TEPLPRRIFK NDKPSKFKSK RKEKDKNSDA    50
    YDEMLLNNNF TLLDQEEPMV EIGSKKSRND NDSEGIRDKG GVEISNKNDP 100
    YIQFGKADPL EPLEKPDLPE EAIKRGEPTI LLGIPKREGR KTNPVHDKAV 150
    ENNSDFIKFD WNSDEDEDSV SNDKSKNNES LKKSSKNEIP GFMRQRGRFF 200
    HEANEKSDSN RKRKRQAYEL DSQSCPWHRQ YKVEREVSRI FHQDILHFID 250
    YITPTPEEHA VRKTLVSRIN QAVLQKWPDV SLYVFGSFET KLYLPTSDLD 300
    LVIISPEHHY RGTKKDMFVL AHHLKKLKLA SEVQVITTAN VPIIKFVDPL 350
    TKVHVDISFN QPGGLKTCLV VNGFMKKYPA LRPLVIIIKH FLNMRALNEV 400
    FLGGLSSYAI VCLVVSFLQL HPRLSTGSMR EEDNFGVLLL EFLELYGKQF 450
    YYDAVGIAVH NGGFYFSKKK MGWLKPNQPY LLSIQDPVDF QNDVSKSSRG 500
    LLRVKATFAN GFDLLTSKLY ALASRIEREG VNRVKDFPSI LSTILSVDEG 550
    VRQHREHMLK CYKNNPVPLE PLVEVDALAS IDVDKLPLQD VGLQYVEDES 600
    DSDETDAAKD DLFKVNESIE TNGHENFQKQ ALTSTGEQSS SNSRANPSKL 650
    FNISSDDSED EVPIIEDTTA SDEESRAKKI RKRF 684
    Length:684
    Mass (Da):78,298
    Last modified:November 8, 2005 - v2
    Checksum:iC2CF653A51C8D39B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAI79317.1.
    PIRiS62544.
    RefSeqiNP_001018181.1. NM_001018285.2.

    Genome annotation databases

    EnsemblFungiiSPAC12G12.13c.1; SPAC12G12.13c.1:pep; SPAC12G12.13c.
    GeneIDi3361384.
    KEGGispo:SPAC12G12.13c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAI79317.1 .
    PIRi S62544.
    RefSeqi NP_001018181.1. NM_001018285.2.

    3D structure databases

    ProteinModelPortali Q9UTN3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 280460. 146 interactions.
    MINTi MINT-4710930.
    STRINGi 4896.SPAC12G12.13c-1.

    Proteomic databases

    MaxQBi Q9UTN3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC12G12.13c.1 ; SPAC12G12.13c.1:pep ; SPAC12G12.13c .
    GeneIDi 3361384.
    KEGGi spo:SPAC12G12.13c.

    Organism-specific databases

    PomBasei SPAC12G12.13c.

    Phylogenomic databases

    eggNOGi COG5260.
    KOi K03514.
    OMAi LISHEEE.
    OrthoDBi EOG7CNZS6.
    PhylomeDBi Q9UTN3.

    Miscellaneous databases

    NextBioi 20811434.

    Family and domain databases

    InterProi IPR002934. Nucleotidyltransferase.
    IPR002058. PAP_assoc.
    [Graphical view ]
    Pfami PF01909. NTP_transf_2. 1 hit.
    PF03828. PAP_assoc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Requirement of fission yeast Cid14 in polyadenylation of rRNAs."
      Win T.Z., Draper S., Read R.L., Pearce J., Norbury C.J., Wang S.-W.
      Mol. Cell. Biol. 26:1710-1721(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
    3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. "RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing."
      Buehler M., Haas W., Gygi S.P., Moazed D.
      Cell 129:707-721(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AIR1.

    Entry informationi

    Entry nameiCID14_SCHPO
    AccessioniPrimary (citable) accession number: Q9UTN3
    Secondary accession number(s): Q09876, Q565C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3