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Protein

L-saccharopine oxidase

Gene

fap2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + H2O + O2 = (S)-2-amino-6-oxohexanoate + L-glutamate + H2O2.1 Publication

Cofactori

FAD1 Publication

Kineticsi

  1. KM=9.02 mM for L-saccharopine1 Publication
  1. Vmax=6.72 µmol/min/mg enzyme for L-pipecolate1 Publication

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: PomBase
  • saccharopine oxidase activity Source: PomBase

GO - Biological processi

  • L-lysine catabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16096.
BRENDAi1.5.3.18. 5613.
SABIO-RKQ9UTM9.

Names & Taxonomyi

Protein namesi
Recommended name:
L-saccharopine oxidaseImported (EC:1.5.3.18)
Gene namesi
Name:fap2Imported
ORF Names:SPAC139.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC139.04c.
PomBaseiSPAC139.04c. fap2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • extracellular region Source: UniProtKB-SubCell
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 433415L-saccharopine oxidaseSequence analysisPRO_0000347275Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9UTM9.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi278260. 2 interactions.
MINTiMINT-4710886.

Structurei

3D structure databases

ProteinModelPortaliQ9UTM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MSOX/MTOX family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ9UTM9.
KOiK17833.
OMAiHAGYANS.
OrthoDBiEOG092C2CCC.
PhylomeDBiQ9UTM9.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UTM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTIVIVGC GVFGLSTAVE LAKNHSFDNI IAIDAEPVPS SMSAANDINK
60 70 80 90 100
IVRPEYADLK YMKLALEAME KWRNDPELSS VYFECGRLST ISKDPYRARF
110 120 130 140 150
DEVAQRNLRK LLGDSALINL SSSEEIRKKY PSLFSNSPLR SDMQAVVNEH
160 170 180 190 200
AGYANSAASL KLLELKAREL GVEFVFGKAG KFKKFVVNHS ETDIDKNDNH
210 220 230 240 250
VSVQTEDGTI YHADTILLAV GAYLNAYLNT SHRVCAKGLP VAHIQLTDEE
260 270 280 290 300
FKTYKNMPII FDPDCAYAFP PYPVTKLIKL ASTGYEYVCN VETDYDENSK
310 320 330 340 350
VVSIPHSGPS KSSLPKYAII QMRRFLDTFL PDLADRSLIN TKMCWISDTE
360 370 380 390 400
DANFLIDKVP QFDNVFVANG DSGHAFKFLP NIGRYIAQRI LGDLSEEWKD
410 420 430
AWRWREDDKA SELKWRCVRS LIDYKDAEFT YDK
Length:433
Mass (Da):48,974
Last modified:May 1, 2000 - v1
Checksum:i170081BB3D48B1BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB59618.1.
PIRiT37605.
RefSeqiNP_593171.1. NM_001018568.2.

Genome annotation databases

EnsemblFungiiSPAC139.04c.1; SPAC139.04c.1:pep; SPAC139.04c.
GeneIDi2541766.
KEGGispo:SPAC139.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB59618.1.
PIRiT37605.
RefSeqiNP_593171.1. NM_001018568.2.

3D structure databases

ProteinModelPortaliQ9UTM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278260. 2 interactions.
MINTiMINT-4710886.

Proteomic databases

MaxQBiQ9UTM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC139.04c.1; SPAC139.04c.1:pep; SPAC139.04c.
GeneIDi2541766.
KEGGispo:SPAC139.04c.

Organism-specific databases

EuPathDBiFungiDB:SPAC139.04c.
PomBaseiSPAC139.04c. fap2.

Phylogenomic databases

InParanoidiQ9UTM9.
KOiK17833.
OMAiHAGYANS.
OrthoDBiEOG092C2CCC.
PhylomeDBiQ9UTM9.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16096.
BRENDAi1.5.3.18. 5613.
SABIO-RKQ9UTM9.

Miscellaneous databases

PROiQ9UTM9.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFAP2_SCHPO
AccessioniPrimary (citable) accession number: Q9UTM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.