Reviewed, UniProtKB/Swiss-Prot Q9UTM8 (SSDH2_SCHPO)

Names and origin

Protein names

Recommended name:
    Putative succinate-semialdehyde dehydrogenase C139.05 [NADP+]
      Short name=SSDH
    EC=1.2.1.16

Gene names

ORF Names:

SPAC139.05

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.
Pathway	Amino-acid degradation; 4-aminobutanoate degradation.
Subcellular location	Cytoplasm. Ref.2
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular response to stress Inferred from expression pattern. Source: GeneDB_SPombe oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Ref.2 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Putative succinate-semialdehyde dehydrogenase C139.05 [NADP+]		PRO_0000310352
Regions
	Nucleotide binding	242 – 247	6	NAD or NADP By similarity
Sites
	Active site	264	1	By similarity
	Active site	298	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UTM8-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 203BC61AA4F20A9B	FASTA	493	53,306
	10 20 30 40 50 60 MAPQFKRPEL FGFDKSHAQS FVQGKWISSP NNKTFEVDNP ATGEIIGKVA DVSVEETKKA 70 80 90 100 110 120 ISAANEAFKT YKNFTHVQRS QLLERWAELI MENKDDLVKM LTLENGKPLS QAEMEVTTCS 130 140 150 160 170 180 GYLKWYAAEA VRTFGDVAPS SLQSQNFLIS IKQPVGVSAL ITPWNFPAAM IARKGGAALA 190 200 210 220 230 240 AGCTAIFLPA FRTPYVCLGL VRLAQEAGFP DGVLNVITSS DASAHGKELT TNPIVRKVSF 250 260 270 280 290 300 TGSTNVGKIL MGQSASTIKK VSMELGGNAP FIVFPDFPID QAVESFCTIK FNSCGQVCVC 310 320 330 340 350 360 PNRVYVHKNV YDEFVSKLTE KVKTIKVGDG FDSSSAVGPL ISQDGCKKVS KHIEDAVSKG 370 380 390 400 410 420 AKITVGGKEI SSSKGYFFEP TVLSGVTQDM LVASEETFGP LASVFKFDDT EEVIEWANDS 430 440 450 460 470 480 DVGLAGYVFT NNLSTMIHVA KELEVGLVGA NIEMVDEPFI SFGGIKQSGF GKEAGRLGVQ 490 EFMVVKEINL KTL

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAB59619.1.
PIR	T37606.
RefSeq	NP_593172.1.
3D structure databases
HSSP	HSSP built from PDB template 1O04 based on UniProtKB P05091.
ModBase	Search...
Genome annotation databases
GeneID	2541647.
KEGG	spo:SPAC139.05.
NMPDR	fig|4896.1.peg.3142.
Organism-specific databases
GeneDB_Spombe	SPAC139.05.
Phylogenomic databases
OMA	Q9UTM8. VIEWAND.
Enzyme and pathway databases
BRENDA	1.2.1.16. 653.
Gene expression databases
ArrayExpress	Q9UTM8.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR010102. Succ_semiAld_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01780. SSADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SSDH2_SCHPO

Accession

Primary (citable) accession number: Q9UTM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)