Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UTM7

- HAT1_SCHPO

UniProt

Q9UTM7 - HAT1_SCHPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone acetyltransferase type B catalytic subunit

Gene

hat1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei161 – 1611Interaction with histone H4 N-terminusBy similarity
Active sitei238 – 2381Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: PomBase

GO - Biological processi

  1. chromatin silencing Source: PomBase
  2. chromatin silencing at telomere Source: InterPro
  3. double-strand break repair Source: PomBase
  4. histone acetylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:hat1
ORF Names:SPAC139.06, SPAC23C4.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC139.06.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. histone acetyltransferase complex Source: PomBase
  3. nuclear chromatin Source: PomBase
  4. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Histone acetyltransferase type B catalytic subunitPRO_0000116791Add
BLAST

Proteomic databases

MaxQBiQ9UTM7.

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail.By similarity

Protein-protein interaction databases

BioGridi278960. 52 interactions.
MINTiMINT-4710866.
STRINGi4896.SPAC139.06-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UTM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 433Interaction with histone H4 N-terminusBy similarity
Regioni183 – 1853Interaction with histone H4 N-terminusBy similarity
Regioni203 – 2053Acetyl-CoA bindingBy similarity
Regioni210 – 2167Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiNOG326277.
InParanoidiQ9UTM7.
KOiK11303.
OMAiWINSKIA.
OrthoDBiEOG7HTHSD.
PhylomeDBiQ9UTM7.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UTM7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAVDEWVHN ANECIEIVQV NEKHEKDCQY HPSNTYAIFG DAEVIYGYKD
60 70 80 90 100
LNVTITYECP LMVPKLEISY SERLAPDSGV EPTDIEGTLN TYLKDRSIKV
110 120 130 140 150
EGNSFDVHSA NSIHNYSFNG KTFKILQATV LEASEIMQHL QIFSLFFIEG
160 170 180 190 200
GSFIDLNDPR WMVYLLYETT EDDYCLRGYC TVYKYYKWDK LIHDGIRARI
210 220 230 240 250
SQFVILPPFQ HQGHGSQLYN AIVSTFLKNP KILDFTVEDA SEAFDSLRDH
260 270 280 290 300
CDYKRLLSMG IFSEPDFHPS LSRQWINSKI AETKLTQRQF SRCCELAFTT
310 320 330 340 350
KLKKLSLLER KSVRLGIKER IFRQNLDVLL QLDKSERIEK IHNAYENQFD
360 370
EYKQIVKKLP KLKEDSPRKR QKLAQSSS
Length:378
Mass (Da):44,051
Last modified:March 29, 2004 - v2
Checksum:i6875CD93528FB3B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB59620.1.
PIRiT37607.
T38257.
RefSeqiNP_593173.2. NM_001018570.2.

Genome annotation databases

EnsemblFungiiSPAC139.06.1; SPAC139.06.1:pep; SPAC139.06.
GeneIDi2542502.
KEGGispo:SPAC139.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB59620.1 .
PIRi T37607.
T38257.
RefSeqi NP_593173.2. NM_001018570.2.

3D structure databases

ProteinModelPortali Q9UTM7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278960. 52 interactions.
MINTi MINT-4710866.
STRINGi 4896.SPAC139.06-1.

Proteomic databases

MaxQBi Q9UTM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC139.06.1 ; SPAC139.06.1:pep ; SPAC139.06 .
GeneIDi 2542502.
KEGGi spo:SPAC139.06.

Organism-specific databases

PomBasei SPAC139.06.

Phylogenomic databases

eggNOGi NOG326277.
InParanoidi Q9UTM7.
KOi K11303.
OMAi WINSKIA.
OrthoDBi EOG7HTHSD.
PhylomeDBi Q9UTM7.

Miscellaneous databases

NextBioi 20803555.
PROi Q9UTM7.

Family and domain databases

Gene3Di 1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiHAT1_SCHPO
AccessioniPrimary (citable) accession number: Q9UTM7
Secondary accession number(s): O13922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3