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Q9UTM7

- HAT1_SCHPO

UniProt

Q9UTM7 - HAT1_SCHPO

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Protein
Histone acetyltransferase type B catalytic subunit
Gene
hat1, SPAC139.06, SPAC23C4.01
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: PomBase

GO - Biological processi

  1. chromatin silencing Source: PomBase
  2. chromatin silencing at telomere Source: InterPro
  3. double-strand break repair Source: PomBase
  4. histone acetylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48)
Gene namesi
Name:hat1
ORF Names:SPAC139.06, SPAC23C4.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC139.06.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. histone acetyltransferase complex Source: PomBase
  3. nuclear chromatin Source: PomBase
  4. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Histone acetyltransferase type B catalytic subunit
PRO_0000116791Add
BLAST

Proteomic databases

MaxQBiQ9UTM7.

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail By similarity.

Protein-protein interaction databases

BioGridi278960. 51 interactions.
MINTiMINT-4710866.
STRINGi4896.SPAC139.06-1.

Structurei

3D structure databases

ProteinModelPortaliQ9UTM7.

Family & Domainsi

Sequence similaritiesi

Belongs to the HAT1 family.

Phylogenomic databases

eggNOGiNOG326277.
KOiK11303.
OMAiWINSKIA.
OrthoDBiEOG7HTHSD.
PhylomeDBiQ9UTM7.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UTM7-1 [UniParc]FASTAAdd to Basket

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MSAVDEWVHN ANECIEIVQV NEKHEKDCQY HPSNTYAIFG DAEVIYGYKD    50
LNVTITYECP LMVPKLEISY SERLAPDSGV EPTDIEGTLN TYLKDRSIKV 100
EGNSFDVHSA NSIHNYSFNG KTFKILQATV LEASEIMQHL QIFSLFFIEG 150
GSFIDLNDPR WMVYLLYETT EDDYCLRGYC TVYKYYKWDK LIHDGIRARI 200
SQFVILPPFQ HQGHGSQLYN AIVSTFLKNP KILDFTVEDA SEAFDSLRDH 250
CDYKRLLSMG IFSEPDFHPS LSRQWINSKI AETKLTQRQF SRCCELAFTT 300
KLKKLSLLER KSVRLGIKER IFRQNLDVLL QLDKSERIEK IHNAYENQFD 350
EYKQIVKKLP KLKEDSPRKR QKLAQSSS 378
Length:378
Mass (Da):44,051
Last modified:March 29, 2004 - v2
Checksum:i6875CD93528FB3B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB59620.1.
PIRiT37607.
T38257.
RefSeqiNP_593173.2. NM_001018570.2.

Genome annotation databases

EnsemblFungiiSPAC139.06.1; SPAC139.06.1:pep; SPAC139.06.
GeneIDi2542502.
KEGGispo:SPAC139.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB59620.1 .
PIRi T37607.
T38257.
RefSeqi NP_593173.2. NM_001018570.2.

3D structure databases

ProteinModelPortali Q9UTM7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278960. 51 interactions.
MINTi MINT-4710866.
STRINGi 4896.SPAC139.06-1.

Proteomic databases

MaxQBi Q9UTM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC139.06.1 ; SPAC139.06.1:pep ; SPAC139.06 .
GeneIDi 2542502.
KEGGi spo:SPAC139.06.

Organism-specific databases

PomBasei SPAC139.06.

Phylogenomic databases

eggNOGi NOG326277.
KOi K11303.
OMAi WINSKIA.
OrthoDBi EOG7HTHSD.
PhylomeDBi Q9UTM7.

Miscellaneous databases

NextBioi 20803555.
PROi Q9UTM7.

Family and domain databases

Gene3Di 1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiHAT1_SCHPO
AccessioniPrimary (citable) accession number: Q9UTM7
Secondary accession number(s): O13922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: May 14, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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