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Protein

Histone acetyltransferase type B catalytic subunit

Gene

hat1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei238Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing at telomere Source: InterPro
  • DNA repair Source: UniProtKB-KW
  • histone acetylation Source: PomBase
  • histone H4-K12 acetylation Source: PomBase
  • histone H4-K5 acetylation Source: PomBase
  • histone H4-K8 acetylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BRENDAi2.3.1.48. 5613.
ReactomeiR-SPO-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:hat1
ORF Names:SPAC139.06, SPAC23C4.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC139.06.
PomBaseiSPAC139.06. hat1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: GOC
  • cytoplasm Source: PomBase
  • histone acetyltransferase complex Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001167911 – 378Histone acetyltransferase type B catalytic subunitAdd BLAST378

Proteomic databases

MaxQBiQ9UTM7.
PRIDEiQ9UTM7.

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei161Interaction with histone H4 N-terminusBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278960. 54 interactors.
MINTiMINT-4710866.

Structurei

3D structure databases

ProteinModelPortaliQ9UTM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 43Interaction with histone H4 N-terminusBy similarity3
Regioni183 – 185Interaction with histone H4 N-terminusBy similarity3
Regioni203 – 205Acetyl-CoA bindingBy similarity3
Regioni210 – 216Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

InParanoidiQ9UTM7.
KOiK11303.
OMAiYIERANC.
OrthoDBiEOG092C3YYH.
PhylomeDBiQ9UTM7.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UTM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVDEWVHN ANECIEIVQV NEKHEKDCQY HPSNTYAIFG DAEVIYGYKD
60 70 80 90 100
LNVTITYECP LMVPKLEISY SERLAPDSGV EPTDIEGTLN TYLKDRSIKV
110 120 130 140 150
EGNSFDVHSA NSIHNYSFNG KTFKILQATV LEASEIMQHL QIFSLFFIEG
160 170 180 190 200
GSFIDLNDPR WMVYLLYETT EDDYCLRGYC TVYKYYKWDK LIHDGIRARI
210 220 230 240 250
SQFVILPPFQ HQGHGSQLYN AIVSTFLKNP KILDFTVEDA SEAFDSLRDH
260 270 280 290 300
CDYKRLLSMG IFSEPDFHPS LSRQWINSKI AETKLTQRQF SRCCELAFTT
310 320 330 340 350
KLKKLSLLER KSVRLGIKER IFRQNLDVLL QLDKSERIEK IHNAYENQFD
360 370
EYKQIVKKLP KLKEDSPRKR QKLAQSSS
Length:378
Mass (Da):44,051
Last modified:March 29, 2004 - v2
Checksum:i6875CD93528FB3B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB59620.1.
PIRiT37607.
T38257.
RefSeqiNP_593173.2. NM_001018570.2.

Genome annotation databases

EnsemblFungiiSPAC139.06.1; SPAC139.06.1:pep; SPAC139.06.
GeneIDi2542502.
KEGGispo:SPAC139.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB59620.1.
PIRiT37607.
T38257.
RefSeqiNP_593173.2. NM_001018570.2.

3D structure databases

ProteinModelPortaliQ9UTM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278960. 54 interactors.
MINTiMINT-4710866.

Proteomic databases

MaxQBiQ9UTM7.
PRIDEiQ9UTM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC139.06.1; SPAC139.06.1:pep; SPAC139.06.
GeneIDi2542502.
KEGGispo:SPAC139.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC139.06.
PomBaseiSPAC139.06. hat1.

Phylogenomic databases

InParanoidiQ9UTM7.
KOiK11303.
OMAiYIERANC.
OrthoDBiEOG092C3YYH.
PhylomeDBiQ9UTM7.

Enzyme and pathway databases

BRENDAi2.3.1.48. 5613.
ReactomeiR-SPO-3214847. HATs acetylate histones.

Miscellaneous databases

PROiQ9UTM7.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHAT1_SCHPO
AccessioniPrimary (citable) accession number: Q9UTM7
Secondary accession number(s): O13922
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.