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Protein

J-type co-chaperone jac1, mitochondrial

Gene

jac1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Co-chaperone required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Stimulates the ATPase activity of the mitochondrial Hsp70 chaperone (mtHsp70). Binds to the substrate protein isu1 and targets it to mtHsp70 (By similarity).By similarity

GO - Molecular functioni

  • ATPase activator activity Source: PomBase
  • chaperone binding Source: InterPro
  • Hsp70 protein binding Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-SPO-1268020 Mitochondrial protein import
R-SPO-1362409 Mitochondrial iron-sulfur cluster biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
J-type co-chaperone jac1, mitochondrial
Alternative name(s):
J-type accessory chaperone 1
Gene namesi
Name:jac1
ORF Names:SPAC144.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC144.08
PomBaseiSPAC144.08 jac1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49MitochondrionSequence analysisAdd BLAST49
ChainiPRO_000036338850 – 225J-type co-chaperone jac1, mitochondrialAdd BLAST176

Proteomic databases

MaxQBiQ9UTL6
PaxDbiQ9UTL6
PRIDEiQ9UTL6

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4896.SPAC144.08.1

Structurei

3D structure databases

ProteinModelPortaliQ9UTL6
SMRiQ9UTL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 137JAdd BLAST77

Sequence similaritiesi

Belongs to the HscB family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiQ9UTL6
OrthoDBiEOG092C4Z2R
PhylomeDBiQ9UTL6

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
1.20.1280.20, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR004640 HscB
IPR036386 HscB_C_sf
IPR009073 HscB_oligo_C
IPR036869 J_dom_sf
PANTHERiPTHR14021 PTHR14021, 1 hit
PfamiView protein in Pfam
PF07743 HSCB_C, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF47144 SSF47144, 1 hit
TIGRFAMsiTIGR00714 hscB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UTL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKQAGNQSF RPFISFAQKS LFNRQITGNH WIFARFKFYP LNKIVNYNHF
60 70 80 90 100
HSSSCQSEAK NFYKQFEGDI SDPPPKGPFD IDLGALKSSY LRKMKTLHPD
110 120 130 140 150
VAQGKDAALA QRDSAELSKA YNTLKAPLTR AEYILQLQGI NPVSEDISNS
160 170 180 190 200
DPEFLMEIMD VHENISASRD SPEKLLQLSQ ENQGRKVQEI NEIRKAMESS
210 220
NWDSALLYVN RLRYWNTIDK ILHDL
Length:225
Mass (Da):25,901
Last modified:May 1, 2000 - v1
Checksum:i41F3DB1FBED9C466
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB59688.1
PIRiT37675
RefSeqiNP_594669.1, NM_001020098.2

Genome annotation databases

EnsemblFungiiSPAC144.08.1; SPAC144.08.1:pep; SPAC144.08
KEGGispo:SPAC144.08

Entry informationi

Entry nameiJAC1_SCHPO
AccessioniPrimary (citable) accession number: Q9UTL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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