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Protein

Transcription factor IIIA

Gene

sfc2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Is required for correct transcription of 5S RNA genes by RNA polymerase III. Also binds the transcribed 5S RNA's. Initiates transcription of the 5S ribosomal RNA gene.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri23 – 4725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri53 – 7725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri83 – 10725C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri113 – 13826C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri144 – 16926C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 26126C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 29125C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37426C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB-KW
  • transcription factor activity, core RNA polymerase III binding Source: PomBase

GO - Biological processi

  • regulation of transcription from RNA polymerase III promoter Source: GOC
  • transcription initiation from RNA polymerase III promoter Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIA
Short name:
TFIIIA
Gene namesi
Name:sfc2
ORF Names:SPAC144.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC144.09c.
PomBaseiSPAC144.09c. sfc2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Transcription factor IIIAPRO_0000047085Add
BLAST

Proteomic databases

MaxQBiQ9UTL5.

Interactioni

Protein-protein interaction databases

MINTiMINT-4710748.

Structurei

3D structure databases

ProteinModelPortaliQ9UTL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri23 – 4725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri53 – 7725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri83 – 10725C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri113 – 13826C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri144 – 16926C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 26126C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 29125C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37426C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoidiQ9UTL5.
OMAiISACHTH.
OrthoDBiEOG789CM8.
PhylomeDBiQ9UTL5.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UTL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHFNELSIE IESKNLRSAK KIFHCPYEEC GKKYSRPSLL EQHLRTHSNE
60 70 80 90 100
RPFVCDYTGC SKAFYRKSHL KIHKRCHTNV KPFSCHYDGC DAQFYTQQHL
110 120 130 140 150
ERHIEVHRKP KPYACTWEGC DECFSKHQQL RSHISACHTH LLPYPCTYQD
160 170 180 190 200
CELRFATKQK LQNHVNRAHE KIISYSCPHE SCVGHEGFEK WSQLQNHIRE
210 220 230 240 250
AHVPSCSICG RQFKTAAHLR HHVVLHQTTL EERKTYHCPM EGCKKSFTRS
260 270 280 290 300
SALKKHISVI HEGNMAFHCD SCGTKFGYKH MLQRHLERGT CKKAHKPYIN
310 320 330 340 350
ECGIKHDGIE GVAIHDQKEK ELSSNLVSDV AKKIINEVTG HGYKEAREYS
360 370
CSFPECNYRF KRLYDMHRHL NSHH
Length:374
Mass (Da):43,851
Last modified:May 1, 2000 - v1
Checksum:i7469C701FFF08FF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY091590 mRNA. Translation: AAM00046.1.
CU329670 Genomic DNA. Translation: CAB59689.1.
PIRiT37676.
RefSeqiNP_594670.1. NM_001020099.2.

Genome annotation databases

EnsemblFungiiSPAC144.09c.1; SPAC144.09c.1:pep; SPAC144.09c.
GeneIDi2542887.
KEGGispo:SPAC144.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY091590 mRNA. Translation: AAM00046.1.
CU329670 Genomic DNA. Translation: CAB59689.1.
PIRiT37676.
RefSeqiNP_594670.1. NM_001020099.2.

3D structure databases

ProteinModelPortaliQ9UTL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4710748.

Proteomic databases

MaxQBiQ9UTL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC144.09c.1; SPAC144.09c.1:pep; SPAC144.09c.
GeneIDi2542887.
KEGGispo:SPAC144.09c.

Organism-specific databases

EuPathDBiFungiDB:SPAC144.09c.
PomBaseiSPAC144.09c. sfc2.

Phylogenomic databases

InParanoidiQ9UTL5.
OMAiISACHTH.
OrthoDBiEOG789CM8.
PhylomeDBiQ9UTL5.

Enzyme and pathway databases

ReactomeiR-SPO-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

Miscellaneous databases

PROiQ9UTL5.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of transcription factor IIIA from Schizosaccharomyces pombe."
    Schulman D.B., Setzer D.R.
    Nucleic Acids Res. 30:2772-2781(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiTF3A_SCHPO
AccessioniPrimary (citable) accession number: Q9UTL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.